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The Canadian veterinary journal = La revue veterinaire canadienne1981; 22(12); 367-371;

Postanesthetic myonecrosis in horses.

Abstract: Two horses died of massive myonecrosis following surgery. The hematological, biochemical and pathological changes are described and compared with those previously reported in the literature.
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Publication Date: 1981-12-01 PubMed ID: 7337914PubMed Central: PMC1790023
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses two cases of postanesthetic myonecrosis, a severe muscle decay condition observed in horses after undergoing surgery. The study details the associated hematological, biochemical, and pathological changes, comparing them to earlier recorded instances.

Objective of the Study

  • The main objective of this research was to investigate and document the occurrences of postanesthetic myonecrosis in horses. This pathological condition, which involves severe muscle degradation, occurred in two horses after surgery, leading to their deaths.

Methodology

  • The researchers carried out a thorough examination of both the cases, documenting the hematological (related to blood), biochemical (pertaining to chemical processes within living organisms), and pathological (associated with diseases) changes observed.
  • The approach taken in the research allowed an in-depth understanding of the conditions leading up to the occurrence of myonecrosis, as well as the transformations in the horses’ physiological processes following the onset of the disorder.

Comparison with Previous Studies

  • The study also involved a comprehensive comparison of the observed changes in the two cases with those mentioned in previously published literature on the topic.
  • This comparative analysis would have enabled the identification of patterns, commonalities, and differences in the manifestation of postanesthetic myonecrosis, thus further broadening the understanding of this disorder.

Significance and Implications

  • The research’s findings are critical as they contribute to the existing knowledge on postanesthetic myonecrosis, a condition that can be lethal in horses.
  • Further understanding of the causes, symptoms, and progression of this disorder can potentially lead to improved diagnostic methods, preventive measures, and possibly treatment methods, thus enhancing veterinary care standards for horses.

Cite This Article

APA
Friend SC. (1981). Postanesthetic myonecrosis in horses. Can Vet J, 22(12), 367-371.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 22
Issue: 12
Pages: 367-371

Researcher Affiliations

Friend, S C

    MeSH Terms

    • Anesthesia / adverse effects
    • Anesthesia / veterinary
    • Animals
    • Calcium Metabolism Disorders / chemically induced
    • Calcium Metabolism Disorders / pathology
    • Calcium Metabolism Disorders / veterinary
    • Halothane / adverse effects
    • Horse Diseases / chemically induced
    • Horse Diseases / pathology
    • Horses
    • Male
    • Muscles / pathology
    • Muscular Diseases / chemically induced
    • Muscular Diseases / veterinary
    • Necrosis / veterinary
    • Postoperative Complications / veterinary

    References

    This article includes 10 references
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      pubmed: 5006987doi: 10.1097/00000542-197201000-00009google scholar: lookup
    2. Short CE, Paddleford RR. Letter: Malignant hyperthermia in the dog.. Anesthesiology 1973 Oct;39(4):462-3.
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    3. Mitchelson KR, Hird FJ. Effect of pH and halothane on muscle and liver mitochondria.. Am J Physiol 1973 Dec;225(6):1393-8.
      pubmed: 4760451doi: 10.1152/ajplegacy.1973.225.6.1393google scholar: lookup
    4. Trim CM, Mason J. Post-anaesthetic forelimb lameness in horses.. Equine Vet J 1973 Apr;5(2):71-6.
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    5. Lindsay WA, McDonell W, Bignell W. Equine postanesthetic forelimb lameness: intracompartmental muscle pressure changes and biochemical patterns.. Am J Vet Res 1980 Dec;41(12):1919-24.
      pubmed: 7212425
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      pubmed: 4433061doi: 10.1097/00000542-197412000-00014google scholar: lookup
    7. Bagshaw RJ, Cox RH, Knight DH, Detweiler DK. Malignant hyperthermia in a Greyhound.. J Am Vet Med Assoc 1978 Jan 1;172(1):61-2.
      pubmed: 624662
    8. Britt BA. Etiology and pathophysiology of malignant hyperthermia.. Fed Proc 1979 Jan;38(1):44-8.
      pubmed: 759238
    9. Ahern CP, Somers CJ, Wilson P, McLoughlin JV. Halothane-induced malignant hyperthermia: creatine phosphate concentration in skeletal muscle as an early indicator of the onset of the syndrome.. J Comp Pathol 1980 Apr;90(2):177-86.
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    10. Lindholm A, Johansson HE, Kjaersgaard P. Acute rhabdomyolysis ("tying-up") in standardbred horses. A morphological and biochemical study.. Acta Vet Scand 1974;15(3):325-39.
      pubmed: 4411856doi: 10.1186/BF03547462google scholar: lookup

    Citations

    This article has been cited 5 times.
    1. Fahlman Å, Edner A, Wenger S, Foggin C, Nyman G. Pulmonary gas exchange and acid-base status during immobilisation of black rhinoceroses (Diceros bicornis) in Zimbabwe. J S Afr Vet Assoc 2016 Dec 2;87(1):e1-e9.
      doi: 10.4102/jsava.v87i1.1328pubmed: 28155294google scholar: lookup
    2. Ayala I, Rodríguez MJ, Aguirre C, Buendía AJ, Belda E, Laredo FG. Postanesthetic brachial triceps myonecrosis in a Spanish-bred horse. Can Vet J 2009 Feb;50(2):189-93.
      pubmed: 19412400
    3. Serteyn D, Pincemail J, Mottart E, Caudron I, Deby C, Deby-Dupont G, Philippart C, Lamy M. [Direct approach for demonstrating free radical phenomena during equine postanesthetic myopathy: preliminary study]. Can J Vet Res 1994 Oct;58(4):309-12.
      pubmed: 7889465
    4. Serteyn D, Deby-Dupont G, Pincemail J, Mottart E, Philippart C, Lamy M. Equine postanaesthetic myositis: thromboxanes, prostacyclin and prostaglandin E2 production. Vet Res Commun 1988;12(2-3):219-26.
      doi: 10.1007/BF00362803pubmed: 3188388google scholar: lookup
    5. O'Brien PJ. Etiopathogenetic defect of malignant hyperthermia: hypersensitive calcium-release channel of skeletal muscle sarcoplasmic reticulum. Vet Res Commun 1987;11(6):527-59.
      doi: 10.1007/BF00396370pubmed: 2453969google scholar: lookup
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