Postprandial serum gastrin concentrations in normal foals.
Abstract: Postprandial gastrin concentrations were assayed in serum samples from a group of six foals at one day, one week, one month and three months of age. Before sampling, each foal was prevented from feeding for 2 h and was then allowed to suck for 15 mins. Blood samples were taken at the start of the meal and at 30 min intervals for the next 3 h. Feeding increased serum gastrin concentrations at one day, one week and one month, with the greatest increases detected at one day. Mean pre-feeding gastrin concentrations were 25.2 +/- 2.3 pg/ml at one day, 22.8 +/- 3.9 pg/ml at one week, 15.2 +/- 2.3 pg/ml at one month and 15.6 +/- 7.5 pg/ml at three months. Highest mean post prandial concentrations were at 60 mins on Day one (47.4 +/- 15.2 pg/ml) and one month (25.2 +/- 4.1 pg/ml) old foals. There was no apparent post prandial increase in serum gastrin concentrations in foals at three months of age. Precise reasons for changes in postprandial serum gastrin concentrations remain unknown. Factors that could be important include maturation of G cell function, alterations in gastrin metabolism and excretion, and changes in gastrointestinal motility with increasing age.
Publication Date: 1989-07-01 PubMed ID: 2767029DOI: 10.1111/j.2042-3306.1989.tb02169.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The research studied the gastrin concentration in the serum of young foals after feeding, observing changes across different age stages: one day, one week, one month, and three months. It was found that the post-feeding gastrin concentration increased up to the age of one month but did not show any increase at three months, the reasons for which are yet to be determined.
Study Design and Methodology
- The research involved a group of six foals which were studied at one day, one week, one month and three months of age.
- Before testing, each foal was prevented from feeding for a period of two hours and was then allowed to suckle for fifteen minutes.
- Blood samples were drawn at designated intervals: at the commencement of feeding and every thirty minutes for a subsequent duration of three hours.
Results
- The concentration of gastrin— a hormone that stimulates the production of gastric acid— in the foals’ serum increased post feeding at one day, one week, and one month, with the greatest increase detected at one day of age.
- The average pre-feeding gastrin concentrations were reported as follows: 25.2 pg/ml at one day, 22.8 pg/ml at one week, 15.2 pg/ml at one month, and 15.6 pg/ml at three months.
- The highest average post-feeding gastrin concentrations were recorded at 60 minutes after feeding, specifically in one-day-old and one-month-old foals. These were measured to be 47.4 pg/ml and 25.2 pg/ml, respectively.
- Interestingly, there was no notable post-feeding increase in serum gastrin concentrations in foals at the age of three months.
Conclusion and Future Study Direction
- The precise reasons for the observed changes in postprandial serum gastrin concentrations remain unknown and open to further research exploration.
- Possible influential factors could incorporate the maturation process of G cell function (the cells in the stomach that secrete gastrin), changes in gastrin metabolism and excretion, and evolving changes in gastrointestinal mobility with increasing age.
Cite This Article
APA
Smyth GB, Young DW, Schumacher J.
(1989).
Postprandial serum gastrin concentrations in normal foals.
Equine Vet J, 21(4), 285-287.
https://doi.org/10.1111/j.2042-3306.1989.tb02169.x Publication
Researcher Affiliations
- Department of Large Animal Surgery, College of Veterinary Medicine, Auburn University, AL 36849-5522.
MeSH Terms
- Animals
- Animals, Suckling / blood
- Eating
- Gastrins / blood
- Horses / blood
- Milk
Citations
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