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Veterinary pathology2025; 3009858251338854; doi: 10.1177/03009858251338854

Poxvirus pathology and pathogenesis in agriculturally important species.

Abstract: Zoonotic poxviruses, including monkeypox virus (MPV), the causative agent for Mpox disease, have gained significant media and scientific attention due to recent outbreaks in human populations across the globe. The increase in human cases of poxvirus infection is not unexpected, as routine vaccination against smallpox (a disease caused by the poxvirus variola virus, which cross protects against other orthopoxviruses) was discontinued in the 1980s after its eradication. Large numbers of vertebrate and invertebrate species are susceptible to infection by . Clinical signs and histologic lesions caused by genetically different poxviruses can be strikingly similar with some notable exceptions (eg, poxviral infections in fish). The purpose of this article is to review poxvirus pathology and pathogenesis observed in species of agricultural significance including poultry, cattle, goats, sheep, camels, swine, rabbits, horses, salmon, and carp.
Publication Date: 2025-05-27 PubMed ID: 40421764DOI: 10.1177/03009858251338854Google Scholar: Lookup
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Summary

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This research article focuses on understanding the pathology and pathogenesis of poxvirus in different agriculturally important species, which has gained importance due to an increased number of human infections resulting from poxviruses.

Understanding Poxvirus Pathology and Pathogenesis

This research paper primarily aims to explore the underlying biology and development of diseases caused by poxviruses – a group of viruses that can cause diseases in both animals and humans. This analysis, however, is primarily focused on diseases manifested in agriculturally significant species.

  • The study mainly revolves around the monkeypox virus (MPV), which causes Mpox disease, and has been notably recognized due to recent outbreaks in human populations worldwide.
  • These sudden outbreaks weren’t surprising to the scientific community as routine vaccination against smallpox, a disease caused by the variola virus (a type of poxvirus), had been discontinued since the 1980s following its eradication.
  • The research emphasizes that a wide range of vertebrate and invertebrate species can be affected by poxvirus infections. The clinical signs and histologic lesions caused by genetically different poxviruses are, more often than not, strikingly alike, with a few exceptions such as poxviral infections in fish.

Focus on Agriculturally Significant Species

The research pays special attention to the influence of poxvirus on species that play a significant role in agriculture, including:

  • Poultry
  • Cattle
  • Goats
  • Sheep
  • Camels
  • Swine
  • Rabbits
  • Horses
  • Salmon
  • Carp

Understanding poxvirus pathology and pathogenesis in these species could have significant implications for managing disease outbreaks, improving animal health and welfare, and ensuring stable agricultural production.

Cite This Article

APA
MacNeill AL, Micheloud JF, Parvin R, Gjessing M, Airas NA, Sant'Ana FJF, Adamek M. (2025). Poxvirus pathology and pathogenesis in agriculturally important species. Vet Pathol, 3009858251338854. https://doi.org/10.1177/03009858251338854

Publication

ISSN: 1544-2217
NlmUniqueID: 0312020
Country: United States
Language: English
Pages: 3009858251338854

Researcher Affiliations

MacNeill, Amy L
  • Colorado State University, Fort Collins, CO.
Micheloud, Juan Francisco
  • Área de Sanidad Animal-IIACS/CIAP-INTA, Salta, Argentina.
  • Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires, Argentina.
  • Universidad Católica de Salta, Salta, Argentina.
Parvin, Rokshana
  • Bangladesh Agricultural University, Mymensingh, Bangladesh.
Gjessing, Mona
  • Norwegian Veterinary Institute, Oslo, Norway.
Airas, Niina A
  • University of Helsinki, Helsinki, Finland.
Sant'Ana, Fabiano José Ferreira de
  • Universidade de Brasília, Brasília, Brazil.
Adamek, Mikolaj
  • University of Veterinary Medicine Hannover, Hannover, Germany.

Citations

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