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Journal of insect science (Online)2005; 3; 7; doi: 10.1093/jis/3.1.7

Practical uses for ecdysteroids in mammals including humans: an update.

Abstract: Ecdysteroids are widely used as inducers for gene-switch systems based on insect ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements. We review here these systems, which are currently mainly used in vitro with cultured cells in order to analyse the role of a wide array of genes, but which are expected to represent the basis for future gene therapy strategies. Such developments raise several questions, which are addressed in detail. First, the metabolic fate of ecdysteroids in mammals, including humans, is only poorly known, and the rapid catabolism of ecdysteroids may impede their use as in vivo inducers. A second set of questions arose in fact much earlier with the pioneering "heterophylic" studies of Burdette in the early sixties on the pharmacological effects of ecdysteroids on mammals. These and subsequent studies showed a wide range of effects, most of them being beneficial for the organism (e.g. hypoglycaemic, hypocholesterolaemic, anabolic). These effects are reviewed and critically analysed, and some hypotheses are proposed to explain the putative mechanisms involved. All of these pharmacological effects have led to the development of a wide array of ecdysteroid-containing preparations, which are primarily used for their anabolic and/or "adaptogenic" properties on humans (or horses or dogs). In the same way, increasing numbers of patents have been deposited concerning various beneficial effects of ecdysteroids in many medical or cosmetic domains, which make ecdysteroids very attractive candidates for several practical uses. It may be questioned whether all these pharmacological actions are compatible with the development of ecdysteroid-inducible gene switches for gene therapy, and also if ecdysteroids should be classified among doping substances.
Publication Date: 2005-04-22 PubMed ID: 15844229PubMed Central: PMC524647DOI: 10.1093/jis/3.1.7Google Scholar: Lookup
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Summary

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The research paper discusses the properties and potential uses of ecdysteroids, a type of insect hormone, in the medical field for humans and mammals. It particularly focuses on the role of ecdysteroids in gene-switch systems and the opportunities, as well as challenges, for its development in gene therapy.

Gene-Switch Systems and Ecdysteroids

  • The paper begins by discussing the current usage of ecdysteroids as inducers in gene-switch systems. These systems involve ecdysteroid receptors and genes of interest placed under the control of ecdysteroid-response elements.
  • Currently, these systems are primarily used in vitro with cultured cells to study the functions of various genes.
  • There is a proposed future use of these systems in gene therapy strategies, which could have far-reaching implications in the medical field.

Metabolic Fate of Ecdysteroids in Mammals

  • The research also notes that the metabolic fate of ecdysteroids in mammals, including humans, is not well-known.
  • This lack of understanding presents a possible hurdle to utilizing ecdysteroids as in-vivo inducers, as their rapid catabolism could pose an issue.

Pharmacological Effects of Ecdysteroids on Mammals

  • The paper reviews studies exploring the effects of ecdysteroids on mammals, many of which have shown beneficial outcomes, such as hypoglycemic, hypocholesterolemic, and anabolic effects.
  • These positive effects have resulted in the development of various ecdysteroid-containing products that leverage their anabolic and “adaptogenic” properties. These preparations are mainly used on humans, horses, and dogs.

Beneficial Effects and Applications of Ecdysteroids

  • The authors also note an increasing number of patents being filed regarding the benefits of ecdysteroids. These cover a diverse range of medical and cosmetic domains, making ecdysteroids attractive candidates for a variety of applications.
  • However, these wide-ranging pharmacological actions, while promising, could pose potential conflicts when developing ecdysteroid-inducible gene switches for gene therapy.
  • Additionally, there’s a question of whether ecdysteroids should be classified among doping substances, given their potent anabolic effects.

Cite This Article

APA
Lafont R, Dinan L. (2005). Practical uses for ecdysteroids in mammals including humans: an update. J Insect Sci, 3, 7. https://doi.org/10.1093/jis/3.1.7

Publication

ISSN: 1536-2442
NlmUniqueID: 101096396
Country: United States
Language: English
Volume: 3
Pages: 7
PII: 7

Researcher Affiliations

Lafont, R
  • Université Pierre et Marie Curie, Institut de Biologie Intégrative, Laboratoire d'Endocrinologie Moléculaire et Evolution, 7 Quai Saint Bernard, Case Courrier No 29, 75252 Paris Cedex 05, France. Rene.Lafont@snv.jussieu.fr
Dinan, L

    MeSH Terms

    • Animals
    • Ecdysteroids / chemistry
    • Ecdysteroids / metabolism
    • Gene Expression Regulation
    • Humans
    • Molecular Structure
    • Plants / metabolism

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