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Home / Equine Research Bank / Pathogens / Presence of Equine and Bovine Coronaviruses, Endoparasites, ...
Pathogens (Basel, Switzerland)2023; 12(8); 1043; doi: 10.3390/pathogens12081043

Presence of Equine and Bovine Coronaviruses, Endoparasites, and Bacteria in Fecal Samples of Horses with Colic.

Abstract: Acute abdominal pain (colic) is one of the major equine health threats worldwide and often necessitates intensive veterinary medical care and surgical intervention. Equine coronavirus (ECoV) infections can cause colic in horses but are rarely considered as a differential diagnosis. To determine the frequency of otherwise undetected ECoV infections in horses with acute colic, fresh fecal samples of 105 horses with acute colic and 36 healthy control horses were screened for viruses belonging to the species by RT-PCR as well as for gastrointestinal helminths and bacteria commonly associated with colic. Horses with colic excreted significantly fewer strongyle eggs than horses without colic. The prevalence of anaerobic, spore-forming, gram-positive bacteria ( and ) was significantly higher in the feces of horses with colic. Six horses with colic (5.7%) and one horse from the control group (2.8%) tested positive for Betacoronaviruses. Coronavirus-positive samples were sequenced to classify the virus by molecular phylogeny (N gene). Interestingly, in three out of six coronavirus-positive horses with colic, sequences closely related to bovine coronaviruses (BCoV) were found. The pathogenic potential of BCoV in horses remains unclear and warrants further investigation.
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Publication Date: 2023-08-15 PubMed ID: 37624003PubMed Central: PMC10458731DOI: 10.3390/pathogens12081043Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the prevalence of Equine coronavirus (ECoV), along with endoparasites and bacteria, in horses suffering from colic, a condition characterised by severe abdominal pain. A comparative analysis was also carried out with healthy control horses. The findings revealed a significantly higher presence of certain types of bacteria and occasional detection of coronaviruses related to bovine coronaviruses in horses with colic.

Study Methodology and Sample Population

  • The study involved the examination of fresh fecal samples from 105 horses having acute colic and 36 healthy control horses.
  • The research sought to determine the degree of undiagnosed ECoV infections in horses that presented with acute colic, which is a significant health issue in horses on a global scale.
  • Specifically, the researchers screened for the existence of viruses of the Betacoronavirus species using RT-PCR.
  • The team also examined the samples for gastrointestinal helminths and bacteria that are often linked to colic.

Key Findings

  • Horses with colic were found to excrete significantly fewer strongyle eggs than horses without colic.
  • Importantly, the feces of horses with colic had a significantly higher occurrence of anaerobic, spore-forming, gram-positive bacteria, specifically Clostridium and Paeniclostridium spp.
  • Six of the horses with colic (representing 5.7% of the cohort) and one horse from the control group (comprising 2.8% of the control group) tested positive for Betacoronaviruses.

Observations on Coronavirus Detection

  • The coronavirus-positive samples underwent sequencing to classify the virus by molecular phylogeny, specifically through the N gene.
  • Interestingly, in three of the six coronavirus-positive horses with colic, bovine coronaviruses (BCoV)-related sequences were detected.
  • The discovery of BCoV-related sequences in horses raises questions about the virus’s potential pathogenicity in equines and necessitates further research.

Cite This Article

APA
Stummer M, Frisch V, Glitz F, Hinney B, Spergser J, Krücken J, Diekmann I, Dimmel K, Riedel C, Cavalleri JV, Rümenapf T, Joachim A, Lyrakis M, Auer A. (2023). Presence of Equine and Bovine Coronaviruses, Endoparasites, and Bacteria in Fecal Samples of Horses with Colic. Pathogens, 12(8), 1043. https://doi.org/10.3390/pathogens12081043

Publication

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
NlmUniqueID: 101596317
Country: Switzerland
Language: English
Volume: 12
Issue: 8
PII: 1043

Researcher Affiliations

Stummer, Moritz
  • Institute of Virology, University of Veterinary Medicine, 1210 Vienna, Austria.
Frisch, Vicky
  • Clinical Unit of Equine Internal Medicine, University of Veterinary Medicine, 1210 Vienna, Austria.
Glitz, Frauke
  • Animal Clinic Würflach, 2732 Würflach, Austria.
Hinney, Barbara
  • Institute of Parasitology, University of Veterinary Medicine, 1210 Vienna, Austria.
Spergser, Joachim
  • Institute of Microbiology, University of Veterinary Medicine, 1210 Vienna, Austria.
Krücken, Jürgen
  • Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany.
Diekmann, Irina
  • Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany.
Dimmel, Katharina
  • Institute of Virology, University of Veterinary Medicine, 1210 Vienna, Austria.
Riedel, Christiane
  • CIRI-Centre International de Recherche en Infectiologie, Univ Lyon, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR5308, ENS Lyon, 46 allée d'Italie, 69364 Lyon, France.
Cavalleri, Jessika-Maximiliane V
  • Clinical Unit of Equine Internal Medicine, University of Veterinary Medicine, 1210 Vienna, Austria.
Rümenapf, Till
  • Institute of Virology, University of Veterinary Medicine, 1210 Vienna, Austria.
Joachim, Anja
  • Institute of Parasitology, University of Veterinary Medicine, 1210 Vienna, Austria.
Lyrakis, Manolis
  • Platform for Bioinformatics and Biostatistics, Department of Biomedical Sciences, University of Veterinary Medicine, 1210 Vienna, Austria.
Auer, Angelika
  • Institute of Virology, University of Veterinary Medicine, 1210 Vienna, Austria.

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 68 references
  1. Bowden A, England GCW, Brennan ML, Mair TS, Furness WA, Freeman SL, Burford JH. Indicators of 'critical' outcomes in 941 horses seen 'out-of-hours' for colic.. Vet Rec 2020 Dec 19;187(12):492.
    doi: 10.1136/vr.105881pubmed: 32719081google scholar: lookup
  2. Archer DC, Proudman CJ. Epidemiological clues to preventing colic.. Vet J 2006 Jul;172(1):29-39.
    doi: 10.1016/j.tvjl.2005.04.002pubmed: 15939639google scholar: lookup
  3. Tinker MK, White NA, Lessard P, Thatcher CD, Pelzer KD, Davis B, Carmel DK. Prospective study of equine colic incidence and mortality.. Equine Vet J 1997 Nov;29(6):448-53.
    doi: 10.1111/j.2042-3306.1997.tb03157.xpubmed: 9413717google scholar: lookup
  4. Curtis L, Burford JH, England GCW, Freeman SL. Risk factors for acute abdominal pain (colic) in the adult horse: A scoping review of risk factors, and a systematic review of the effect of management-related changes.. PLoS One 2019;14(7):e0219307.
    doi: 10.1371/journal.pone.0219307pmc: PMC6622499pubmed: 31295284google scholar: lookup
  5. Oue Y, Ishihara R, Edamatsu H, Morita Y, Yoshida M, Yoshima M, Hatama S, Murakami K, Kanno T. Isolation of an equine coronavirus from adult horses with pyrogenic and enteric disease and its antigenic and genomic characterization in comparison with the NC99 strain.. Vet Microbiol 2011 May 12;150(1-2):41-8.
    doi: 10.1016/j.vetmic.2011.01.004pmc: PMC7117184pubmed: 21273011google scholar: lookup
  6. Oue Y, Morita Y, Kondo T, Nemoto M. Epidemic of equine coronavirus at Obihiro Racecourse, Hokkaido, Japan in 2012.. J Vet Med Sci 2013;75(9):1261-5.
    doi: 10.1292/jvms.13-0056pubmed: 23648375google scholar: lookup
  7. Pusterla N, Mapes S, Wademan C, White A, Ball R, Sapp K, Burns P, Ormond C, Butterworth K, Bartol J, Magdesian KG. Emerging outbreaks associated with equine coronavirus in adult horses.. Vet Microbiol 2013 Feb 22;162(1):228-31.
    doi: 10.1016/j.vetmic.2012.10.014pmc: PMC7117461pubmed: 23123176google scholar: lookup
  8. Woo PCY, de Groot RJ, Haagmans B, Lau SKP, Neuman BW, Perlman S, Sola I, van der Hoek L, Wong ACP, Yeh SH. ICTV Virus Taxonomy Profile: Coronaviridae 2023.. J Gen Virol 2023 Apr;104(4).
    doi: 10.1099/jgv.0.001843pubmed: 37097842google scholar: lookup
  9. Zhang J, Guy JS, Snijder EJ, Denniston DA, Timoney PJ, Balasuriya UB. Genomic characterization of equine coronavirus.. Virology 2007 Dec 5;369(1):92-104.
    doi: 10.1016/j.virol.2007.06.035pmc: PMC7103287pubmed: 17706262google scholar: lookup
  10. Guy JS, Breslin JJ, Breuhaus B, Vivrette S, Smith LG. Characterization of a coronavirus isolated from a diarrheic foal.. J Clin Microbiol 2000 Dec;38(12):4523-6.
    doi: 10.1128/JCM.38.12.4523-4526.2000pmc: PMC87631pubmed: 11101590google scholar: lookup
  11. Nemoto M, Schofield W, Cullinane A. The First Detection of Equine Coronavirus in Adult Horses and Foals in Ireland.. Viruses 2019 Oct 14;11(10).
    doi: 10.3390/v11100946pmc: PMC6832964pubmed: 31615132google scholar: lookup
  12. Narita M, Nobumoto K, Takeda H, Moryama T, Morita Y, Nakaoka Y. Prevalence of Disease with Inference of Equine Coronavirus Infection Among Horses Stabled in a Draft-Horse Racecourse. J. Jpn. Vet. Med. Assoc. 2011;64:535–539.
    doi: 10.12935/jvma.64.535google scholar: lookup
  13. Fielding CL, Higgins JK, Higgins JC, McIntosh S, Scott E, Giannitti F, Mete A, Pusterla N. Disease associated with equine coronavirus infection and high case fatality rate.. J Vet Intern Med 2015 Jan;29(1):307-10.
    doi: 10.1111/jvim.12480pmc: PMC4858071pubmed: 25319406google scholar: lookup
  14. Auer A, Junge HK, Glitz F, Dimmel K, Leidinger J, Cavalleri J, Rümenapf T. Equine Coronavirus Is an Underestimated Pathogen in Austria. Vet. Med. Austria 2020;107:236–242.
  15. Nemoto M, Oue Y, Morita Y, Kanno T, Kinoshita Y, Niwa H, Ueno T, Katayama Y, Bannai H, Tsujimura K, Yamanaka T, Kondo T. Experimental inoculation of equine coronavirus into Japanese draft horses.. Arch Virol 2014 Dec;159(12):3329-34.
    doi: 10.1007/s00705-014-2205-1pmc: PMC7087042pubmed: 25139547google scholar: lookup
  16. Giannitti F, Diab S, Mete A, Stanton JB, Fielding L, Crossley B, Sverlow K, Fish S, Mapes S, Scott L, Pusterla N. Necrotizing Enteritis and Hyperammonemic Encephalopathy Associated With Equine Coronavirus Infection in Equids.. Vet Pathol 2015 Nov;52(6):1148-56.
    doi: 10.1177/0300985814568683pubmed: 25648965google scholar: lookup
  17. Pusterla N, Vin R, Leutenegger CM, Mittel LD, Divers TJ. Enteric coronavirus infection in adult horses.. Vet J 2018 Jan;231:13-18.
    doi: 10.1016/j.tvjl.2017.11.004pmc: PMC7110460pubmed: 29429482google scholar: lookup
  18. Schaefer E, Harms C, Viner M, Barnum S, Pusterla N. Investigation of an experimental infection model of equine coronavirus in adult horses.. J Vet Intern Med 2018 Nov;32(6):2099-2104.
    doi: 10.1111/jvim.15318pmc: PMC6271284pubmed: 30353949google scholar: lookup
  19. Berryhill EH, Magdesian KG, Aleman M, Pusterla N. Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital: 33 cases (2012-2018).. Vet J 2019 Jun;248:95-100.
    doi: 10.1016/j.tvjl.2019.05.001pmc: PMC7110482pubmed: 31113572google scholar: lookup
  20. Goodrich EL, Mittel LD, Glaser A, Ness SL, Radcliffe RM, Divers TJ. Novel findings from a beta coronavirus outbreak on an American Miniature Horse breeding farm in upstate New York.. Equine Vet Educ 2020 Mar;32(3):150-154.
    doi: 10.1111/eve.12938pmc: PMC7163602pubmed: 32313400google scholar: lookup
  21. Mattei DN, Kopper JJ, Sanz MG. Equine Coronavirus-Associated Colitis in Horses: A Retrospective Study.. J Equine Vet Sci 2020 Apr;87:102906.
    doi: 10.1016/j.jevs.2019.102906pmc: PMC7126555pubmed: 32172908google scholar: lookup
  22. Love S, Murphy D, Mellor D. Pathogenicity of cyathostome infection.. Vet Parasitol 1999 Aug 31;85(2-3):113-21; discussion 121-2, 215-25.
    doi: 10.1016/S0304-4017(99)00092-8pubmed: 10485358google scholar: lookup
  23. Murphy D, Love S. The pathogenic effects of experimental cyathostome infections in ponies.. Vet Parasitol 1997 Jun;70(1-3):99-110.
    doi: 10.1016/S0304-4017(96)01153-3pubmed: 9195714google scholar: lookup
  24. Gehlen H, Wulke N, Ertelt A, Nielsen MK, Morelli S, Traversa D, Merle R, Wilson D, Samson-Himmelstjerna GV. Comparative Analysis of Intestinal Helminth Infections in Colic and Non-Colic Control Equine Patients.. Animals (Basel) 2020 Oct 19;10(10).
    doi: 10.3390/ani10101916pmc: PMC7603170pubmed: 33086590google scholar: lookup
  25. Reinemeyer CR, Nielsen MK. Parasitism and colic.. Vet Clin North Am Equine Pract 2009 Aug;25(2):233-45.
    doi: 10.1016/j.cveq.2009.04.003pubmed: 19580936google scholar: lookup
  26. Slocombe JO. Pathogenesis of helminths in equines.. Vet Parasitol 1985 Aug;18(2):139-53.
    doi: 10.1016/0304-4017(85)90063-9pubmed: 2930935google scholar: lookup
  27. Stancampiano L, Usai F, Marigo A, Rinnovati R. Are small strongyles (Cyathostominae) involved in horse colic occurrence?. Vet Parasitol 2017 Nov 30;247:33-36.
    doi: 10.1016/j.vetpar.2017.09.020pubmed: 29080761google scholar: lookup
  28. Fabiani JV, Lyons ET, Nielsen MK. Dynamics of Parascaris and Strongylus spp. parasites in untreated juvenile horses.. Vet Parasitol 2016 Oct 30;230:62-66.
    doi: 10.1016/j.vetpar.2016.11.002pubmed: 27884444google scholar: lookup
  29. Proudman CJ, French NP, Trees AJ. Tapeworm infection is a significant risk factor for spasmodic colic and ileal impaction colic in the horse.. Equine Vet J 1998 May;30(3):194-9.
    doi: 10.1111/j.2042-3306.1998.tb04487.xpubmed: 9622319google scholar: lookup
  30. Hedberg-Alm Y, Penell J, Riihimäki M, Osterman-Lind E, Nielsen MK, Tydén E. Parasite Occurrence and Parasite Management in Swedish Horses Presenting with Gastrointestinal Disease-A Case-Control Study.. Animals (Basel) 2020 Apr 7;10(4).
    doi: 10.3390/ani10040638pmc: PMC7222828pubmed: 32272754google scholar: lookup
  31. Jürgenschellert L, Krücken J, Austin CJ, Lightbody KL, Bousquet E, von Samson-Himmelstjerna G. Investigations on the occurrence of tapeworm infections in German horse populations with comparison of different antibody detection methods based on saliva and serum samples.. Parasit Vectors 2020 Sep 10;13(1):462.
    doi: 10.1186/s13071-020-04318-5pmc: PMC7488081pubmed: 32912340google scholar: lookup
  32. Costa MC, Arroyo LG, Allen-Vercoe E, Stämpfli HR, Kim PT, Sturgeon A, Weese JS. Comparison of the fecal microbiota of healthy horses and horses with colitis by high throughput sequencing of the V3-V5 region of the 16S rRNA gene.. PLoS One 2012;7(7):e41484.
    doi: 10.1371/journal.pone.0041484pmc: PMC3409227pubmed: 22859989google scholar: lookup
  33. Garber A, Hastie P, Murray JA. Factors Influencing Equine Gut Microbiota: Current Knowledge.. J Equine Vet Sci 2020 May;88:102943.
    doi: 10.1016/j.jevs.2020.102943pubmed: 32303307google scholar: lookup
  34. Stewart HL, Pitta D, Indugu N, Vecchiarelli B, Hennessy ML, Engiles JB, Southwood LL. Changes in the faecal bacterial microbiota during hospitalisation of horses with colic and the effect of different causes of colic.. Equine Vet J 2021 Nov;53(6):1119-1131.
    doi: 10.1111/evj.13389pubmed: 33222287google scholar: lookup
  35. Uzal FA, Navarro MA, Asin J, Henderson EE. Clostridial Diseases of Horses: A Review.. Vaccines (Basel) 2022 Feb 17;10(2).
    doi: 10.3390/vaccines10020318pmc: PMC8876495pubmed: 35214776google scholar: lookup
  36. Weese JS, Staempfli HR, Prescott JF. A prospective study of the roles of clostridium difficile and enterotoxigenic Clostridium perfringens in equine diarrhoea.. Equine Vet J 2001 Jul;33(4):403-9.
    doi: 10.2746/042516401776249534pubmed: 11469775google scholar: lookup
  37. Schoster A, Kunz T, Lauper M, Graubner C, Schmitt S, Weese JS. Prevalence of Clostridium difficile and Clostridium perfringens in Swiss horses with and without gastrointestinal disease and microbiota composition in relation to Clostridium difficile shedding.. Vet Microbiol 2019 Dec;239:108433.
    doi: 10.1016/j.vetmic.2019.108433pubmed: 31767096google scholar: lookup
  38. Stewart HL, Southwood LL, Indugu N, Vecchiarelli B, Engiles JB, Pitta D. Differences in the equine faecal microbiota between horses presenting to a tertiary referral hospital for colic compared with an elective surgical procedure.. Equine Vet J 2019 May;51(3):336-342.
    doi: 10.1111/evj.13010pubmed: 30153353google scholar: lookup
  39. Manship AJ, Blikslager AT, Elfenbein JR. Disease features of equine coronavirus and enteric salmonellosis are similar in horses.. J Vet Intern Med 2019 Mar;33(2):912-917.
    doi: 10.1111/jvim.15386pmc: PMC6430874pubmed: 30632200google scholar: lookup
  40. Dallap Schaer BL, Aceto H, Caruso MA 3rd, Brace MA. Identification of predictors of Salmonella shedding in adult horses presented for acute colic.. J Vet Intern Med 2012 Sep-Oct;26(5):1177-85.
    doi: 10.1111/j.1939-1676.2012.00984.xpubmed: 22882526google scholar: lookup
  41. Spiss S, Benetka V, Künzel F, Sommerfeld-Stur I, Walk K, Latif M, Möstl K. Enteric and Respiratory Coronavirus Infections in Austrian Dogs: Serological and Virological Investigations of Prevalence and Clinical Importance in Respiratory and Enteric Disease. Vet. Med. Austria 2012;99:67–81.
  42. Mapes S, Rhodes DM, Wilson WD, Leutenegger CM, Pusterla N. Comparison of five real-time PCR assays for detecting virulence genes in isolates of Escherichia coli from septicaemic neonatal foals.. Vet Rec 2007 Nov 24;161(21):716-8.
    doi: 10.1136/vr.161.21.716pubmed: 18037693google scholar: lookup
  43. Tamura K, Nei M. Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees.. Mol Biol Evol 1993 May;10(3):512-26.
    doi: 10.1093/OXFORDJOURNALS.MOLBEV.A040023pubmed: 8336541google scholar: lookup
  44. Tamura K, Stecher G, Kumar S. MEGA11: Molecular Evolutionary Genetics Analysis Version 11.. Mol Biol Evol 2021 Jun 25;38(7):3022-3027.
    doi: 10.1093/molbev/msab120pmc: PMC8233496pubmed: 33892491google scholar: lookup
  45. Nielsen MK, Peterson DS, Monrad J, Thamsborg SM, Olsen SN, Kaplan RM. Detection and semi-quantification of Strongylus vulgaris DNA in equine faeces by real-time quantitative PCR.. Int J Parasitol 2008 Mar;38(3-4):443-53.
    doi: 10.1016/j.ijpara.2007.07.014pubmed: 17889881google scholar: lookup
  46. Jürgenschellert L, Krücken J, Bousquet E, Bartz J, Heyer N, Nielsen MK, von Samson-Himmelstjerna G. Occurrence of Strongylid Nematode Parasites on Horse Farms in Berlin and Brandenburg, Germany, With High Seroprevalence of Strongylus vulgaris Infection.. Front Vet Sci 2022;9:892920.
    doi: 10.3389/fvets.2022.892920pmc: PMC9226773pubmed: 35754549google scholar: lookup
  47. Spergser J, Loncaric I, Tichy A, Fritz J, Scope A. The cultivable autochthonous microbiota of the critically endangered Northern bald ibis (Geronticus eremita).. PLoS One 2018;13(4):e0195255.
    doi: 10.1371/journal.pone.0195255pmc: PMC5884550pubmed: 29617453google scholar: lookup
  48. Jones GF, Ward GE, Murtaugh MP, Lin G, Gebhart CJ. Enhanced detection of intracellular organism of swine proliferative enteritis, ileal symbiont intracellularis, in feces by polymerase chain reaction.. J Clin Microbiol 1993 Oct;31(10):2611-5.
    doi: 10.1128/jcm.31.10.2611-2615.1993pmc: PMC265945pubmed: 8253956google scholar: lookup
  49. R Core Team. R: A Language and Environment for Statistical Computing. .
  50. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J. R. Stat. Soc. Ser. B (Methodol.) 1995;57:289–300.
    doi: 10.1111/j.2517-6161.1995.tb02031.xgoogle scholar: lookup
  51. Hepworth-Warren KL, Erwin SJ, Moore CB, Talbot JR, Young KAS, Neault MJ, Haugland JC, Robertson JB, Blikslager AT. Risk factors associated with an outbreak of equine coronavirus at a large farm in North Carolina.. Front Vet Sci 2023;10:1060759.
    doi: 10.3389/fvets.2023.1060759pmc: PMC10020641pubmed: 36937023google scholar: lookup
  52. Hierweger MM, Remy-Wohlfender F, Franzen J, Koch MC, Blau D, Schoster A, Nicholson P, Gerber V, Gurtner C, Fouché N, Unger L, Seuberlich T. Outbreak of equine coronavirus disease in adult horses, Switzerland 2021.. Transbound Emerg Dis 2022 Jul;69(4):1691-1694.
    doi: 10.1111/tbed.14501pubmed: 35243797google scholar: lookup
  53. Pusterla N. Equine Coronaviruses.. Vet Clin North Am Equine Pract 2023 Apr;39(1):55-71.
    doi: 10.1016/j.cveq.2022.11.008pubmed: 36737293google scholar: lookup
  54. Cohen ND, Gibbs PG, Woods AM. Dietary and other management factors associated with colic in horses.. J Am Vet Med Assoc 1999 Jul 1;215(1):53-60.
    pubmed: 10397066
  55. Daniels SP, Leng J, Swann JR, Proudman CJ. Bugs and drugs: a systems biology approach to characterising the effect of moxidectin on the horse's faecal microbiome.. Anim Microbiome 2020 Oct 14;2(1):38.
    doi: 10.1186/s42523-020-00056-2pmc: PMC7807906pubmed: 33499996google scholar: lookup
  56. Herholz C, Miserez R, Nicolet J, Frey J, Popoff M, Gibert M, Gerber H, Straub R. Prevalence of beta2-toxigenic Clostridium perfringens in horses with intestinal disorders.. J Clin Microbiol 1999 Feb;37(2):358-61.
    doi: 10.1128/JCM.37.2.358-361.1999pmc: PMC84307pubmed: 9889218google scholar: lookup
  57. Burgess BA. Salmonella in Horses.. Vet Clin North Am Equine Pract 2023 Apr;39(1):25-35.
    doi: 10.1016/j.cveq.2022.11.005pubmed: 36737292google scholar: lookup
  58. Sanz MG, Kwon S, Pusterla N, Gold JR, Bain F, Evermann J. Evaluation of equine coronavirus fecal shedding among hospitalized horses.. J Vet Intern Med 2019 Mar;33(2):918-922.
    doi: 10.1111/jvim.15449pmc: PMC6430884pubmed: 30788861google scholar: lookup
  59. Barros IN, Silva SO, Nogueira Neto FS, Asano KM, Souza SP, Richtzenhain LJ, Brandao PE. A multigene approach for comparing genealogy of Betacoronavirus from cattle and horses.. ScientificWorldJournal 2013;2013:349702.
    doi: 10.1155/2013/349702pmc: PMC3855977pubmed: 24348152google scholar: lookup
  60. Zhu Q, Li B, Sun D. Advances in Bovine Coronavirus Epidemiology.. Viruses 2022 May 21;14(5).
    doi: 10.3390/v14051109pmc: PMC9147158pubmed: 35632850google scholar: lookup
  61. Shally-Jensen M. Encyclopedia of Contemporary American Social Issues. .
  62. Vijgen L, Keyaerts E, Moës E, Thoelen I, Wollants E, Lemey P, Vandamme AM, Van Ranst M. Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event.. J Virol 2005 Feb;79(3):1595-604.
    doi: 10.1128/JVI.79.3.1595-1604.2005pmc: PMC544107pubmed: 15650185google scholar: lookup
  63. Berche P. The enigma of the 1889 Russian flu pandemic: A coronavirus?. Presse Med 2022 Sep;51(3):104111.
    doi: 10.1016/j.lpm.2022.104111pmc: PMC8813723pubmed: 35124103google scholar: lookup
  64. Kaneshima T, Hohdatsu T, Hagino R, Hosoya S, Nojiri Y, Murata M, Takano T, Tanabe M, Tsunemitsu H, Koyama H. The infectivity and pathogenicity of a group 2 bovine coronavirus in pups.. J Vet Med Sci 2007 Mar;69(3):301-3.
    doi: 10.1292/jvms.69.301pubmed: 17409649google scholar: lookup
  65. Erles K, Shiu KB, Brownlie J. Isolation and sequence analysis of canine respiratory coronavirus.. Virus Res 2007 Mar;124(1-2):78-87.
    doi: 10.1016/j.virusres.2006.10.004pmc: PMC7114246pubmed: 17092595google scholar: lookup
  66. Amer HM. Bovine-like coronaviruses in domestic and wild ruminants.. Anim Health Res Rev 2018 Dec;19(2):113-124.
    doi: 10.1017/S1466252318000117pmc: PMC7108644pubmed: 30683171google scholar: lookup
  67. Savard C, Provost C, Ariel O, Morin S, Fredrickson R, Gagnon CA, Broes A, Wang L. First report and genomic characterization of a bovine-like coronavirus causing enteric infection in an odd-toed non-ruminant species (Indonesian tapir, Acrocodia indica) during an outbreak of winter dysentery in a zoo.. Transbound Emerg Dis 2022 Sep;69(5):3056-3065.
    doi: 10.1111/tbed.14300pmc: PMC8943714pubmed: 34427399google scholar: lookup
  68. Leopardi S, Desiato R, Mazzucato M, Orusa R, Obber F, Averaimo D, Berjaoui S, Canziani S, Capucchio MT, Conti R, di Bella S, Festa F, Garofalo L, Lelli D, Madrau MP, Mandola ML, Moreno Martin AM, Peletto S, Pirani S, Robetto S, Torresi C, Varotto M, Citterio C, Terregino C. One health surveillance strategy for coronaviruses in Italian wildlife.. Epidemiol Infect 2023 Jun 1;151:e96.
    doi: 10.1017/S095026882300081Xpmc: PMC10282179pubmed: 37263583google scholar: lookup

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