FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Int J Antimicrob Agents / Prevalence, distribution and characterisation of ceftiofur r...
International journal of antimicrobial agents2007; 30(2); 134-142; doi: 10.1016/j.ijantimicag.2007.03.013

Prevalence, distribution and characterisation of ceftiofur resistance in Salmonella enterica isolated from animals in the USA from 1999 to 2003.

Abstract: Third-generation cephalosporin (3GC) antimicrobials are the drugs of choice for treatment of salmonellosis in children. Salmonella isolated in the USA are assayed by the National Antimicrobial Resistance Monitoring System (NARMS) for resistance to antimicrobials including first-, second- and third-generation cephalosporins. From 1999 to 2003, 34,411 Salmonella were isolated from animals in the USA, of which 10.9% were found to be resistant to ceftiofur, a 3GC used in animals, whilst only 0.3% were resistant to ceftriaxone, a 3GC used in human medicine. Ceftiofur resistance rose from 4.0% in 1999 to 18.8% in 2003. Isolates from diagnostic laboratories had higher levels of resistance (18.5%), whereas levels in isolates from on-farm (3.4%) and slaughter (7.1%) sources were lower. Animals with a higher than average proportion of resistant Salmonella included cattle (17.6%), horses (19.2%) and dogs (20.8%). Levels in turkeys (6.8%), chickens (7.1%), eggs (3.6%) and swine (4.6%) were lower. Resistance varied between Salmonella serotypes. A few serotypes had significantly high levels, e.g. S. Newport was 70.4% ceftiofur resistant. Resistance was predominantly associated with bla(CMY-2)-encoding plasmids. These data suggest that the acquisition of resistance plasmids and the spread of specific serotypes harbouring these plasmids are driving the observed resistance to ceftiofur in Salmonella animal isolates.
Get Full Text
Publication Date: 2007-05-24 PubMed ID: 17531447DOI: 10.1016/j.ijantimicag.2007.03.013Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the occurrence and spread of ceftiofur resistance in Salmonella enterica from animals in the USA between 1999 and 2003. It finds that approximately 11% of the bacteria samples were resistant to ceftiofur, an antibiotic used in animals, with certain animals and Salmonella types showing a high frequency of resistance.

Introduction and Methods

  • The research explores the resistance of Salmonella enterica to third-generation cephalosporin (3GC) antimicrobials, specifically ceftiofur, which are the preferred drugs for treating salmonellosis in children.
  • This investigation was conducted using data collected by the National Antimicrobial Resistance Monitoring System (NARMS) in the USA, which keeps track of antimicrobial resistance in pathogens.
  • From 1999 to 2003, NARMS collected and analyzed 34,411 Salmonella isolates from different animal species.

Results

  • The results showed that 10.9% of the Salmonella isolates were resistant to ceftiofur, compared to only 0.3% showing resistance to ceftriaxone, another 3GC used in human medicine.
  • The prevalence of ceftiofur resistance among Salmonella isolates climbed from 4.0% in 1999 to 18.8% in 2003.
  • The degree of resistance varied with the type of source. Diagnostic laboratories showed the highest levels of resistance (18.5%), while on-farm (3.4%) and slaughter sources (7.1%) showed lower levels of resistance.
  • The resistance also varied among different animals. Higher than average proportions of resistant Salmonella were found in cattle (17.6%), horses (19.2%), and dogs (20.8%), while lower levels were found in turkeys (6.8%), chickens (7.1%), eggs (3.6%) and swine (4.6%).
  • There were also differences in resistance among Salmonella serotypes. For instance, Salmonella Newport had a significantly high level of resistance at 70.4%.

Conclusions

  • Ceftiofur resistance was predominantly associated with the bla(CMY-2)-encoding plasmids. Plasmids are small bits of DNA that bacteria can acquire and pass on, often carrying resistance genes.
  • The high levels of resistance to ceftiofur in certain serotypes and the spread of resistant plasmids have likely contributed to the growing resistance to ceftiofur seen in the Salmonella isolates.

Cite This Article

APA
Frye JG, Fedorka-Cray PJ. (2007). Prevalence, distribution and characterisation of ceftiofur resistance in Salmonella enterica isolated from animals in the USA from 1999 to 2003. Int J Antimicrob Agents, 30(2), 134-142. https://doi.org/10.1016/j.ijantimicag.2007.03.013

Publication

International journal of antimicrobial agents
ISSN: 0924-8579
NlmUniqueID: 9111860
Country: Netherlands
Language: English
Volume: 30
Issue: 2
Pages: 134-142

Researcher Affiliations

Frye, Jonathan G
  • Bacterial Epidemiology and Antimicrobial Resistance Research Unit, US Department of Agriculture, Agriculture Research Service, Richard B. Russell Research Center, 950 College Station Road, Athens, GA 30605, USA.
Fedorka-Cray, Paula J

    MeSH Terms

    • Animals
    • Anti-Bacterial Agents / pharmacology
    • Cephalosporin Resistance
    • Cephalosporins / pharmacology
    • Drug Resistance, Multiple, Bacterial
    • Humans
    • Plasmids
    • Prevalence
    • Salmonella Food Poisoning / microbiology
    • Salmonella Infections, Animal / diagnosis
    • Salmonella Infections, Animal / epidemiology
    • Salmonella Infections, Animal / microbiology
    • Salmonella enterica / classification
    • Salmonella enterica / drug effects
    • Salmonella enterica / isolation & purification
    • Serotyping
    • United States

    Citations

    This article has been cited 25 times.
    1. Gelalcha BD, Kerro Dego O. Extended-Spectrum Beta-Lactamases Producing Enterobacteriaceae in the USA Dairy Cattle Farms and Implications for Public Health.. Antibiotics (Basel) 2022 Sep 27;11(10).
      doi: 10.3390/antibiotics11101313pubmed: 36289970google scholar: lookup
    2. Usmael B, Abraha B, Alemu S, Mummed B, Hiko A, Abdurehman A. Isolation, antimicrobial susceptibility patterns, and risk factors assessment of non-typhoidal Salmonella from apparently healthy and diarrheic dogs.. BMC Vet Res 2022 Jan 15;18(1):37.
      doi: 10.1186/s12917-021-03135-xpubmed: 35033077google scholar: lookup
    3. Basbas C, Byrne BA, Chigerwe M, Escobar ED, Hodzic E, Pires AFA, Pereira RV. Detection of Cephalosporin and Fluoroquinolone Resistance Genes via Novel Multiplex qPCR in Fecal Salmonella Isolates From Northern Californian Dairy Cattle, 2002-2016.. Front Microbiol 2021;12:601924.
      doi: 10.3389/fmicb.2021.601924pubmed: 33658984google scholar: lookup
    4. Raseala CM, Ekwanzala MD, Momba MNB. Shared Extended-Spectrum β-Lactamase-Producing Salmonella Serovars between Agricultural and Aquatic Environments Revealed through invA Amplicon Sequencing.. Microorganisms 2020 Nov 30;8(12).
      doi: 10.3390/microorganisms8121898pubmed: 33265988google scholar: lookup
    5. Awad A, Gwida M, Khalifa E, Sadat A. Phenotypes, antibacterial-resistant profile, and virulence-associated genes of Salmonella serovars isolated from retail chicken meat in Egypt.. Vet World 2020 Mar;13(3):440-445.
      doi: 10.14202/vetworld.2020.440-445pubmed: 32367947google scholar: lookup
    6. Dantas Palmeira J, Ferreira HMN. Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production - a threat around the world.. Heliyon 2020 Jan;6(1):e03206.
      doi: 10.1016/j.heliyon.2020.e03206pubmed: 32042963google scholar: lookup
    7. Sukmawinata E, Sato W, Mitoma S, Kanda T, Kusano K, Kambayashi Y, Sato T, Ishikawa Y, Goto Y, Uemura R, Sueyoshi M. Extended-spectrum β-lactamase-producing Escherichia coli isolated from healthy Thoroughbred racehorses in Japan.. J Equine Sci 2019 Sep;30(3):47-53.
      doi: 10.1294/jes.30.47pubmed: 31592106google scholar: lookup
    8. Denagamage TN, Wallner-Pendleton E, Jayarao BM, Xiaoli L, Dudley EG, Wolfgang D, Kariyawasam S. Detection of CTX-M-1 extended-spectrum beta-lactamase among ceftiofur-resistant Salmonella enterica clinical isolates of poultry.. J Vet Diagn Invest 2019 Sep;31(5):681-687.
      doi: 10.1177/1040638719864384pubmed: 31342869google scholar: lookup
    9. Fischer EAJ, Dierikx CM, van Essen-Zandbergen A, Mevius D, Stegeman A, Velkers FC, Klinkenberg D. Competition between Escherichia coli Populations with and without Plasmids Carrying a Gene Encoding Extended-Spectrum Beta-Lactamase in the Broiler Chicken Gut.. Appl Environ Microbiol 2019 Sep 1;85(17).
      doi: 10.1128/AEM.00892-19pubmed: 31253677google scholar: lookup
    10. Ohta N, Norman KN, Norby B, Lawhon SD, Vinasco J, den Bakker H, Loneragan GH, Scott HM. Population dynamics of enteric Salmonella in response to antimicrobial use in beef feedlot cattle.. Sci Rep 2017 Oct 30;7(1):14310.
      doi: 10.1038/s41598-017-14751-9pubmed: 29085049google scholar: lookup
    11. Zehra A, Singh R, Kaur S, Gill JPS. Molecular characterization of antibiotic-resistant Staphylococcus aureus from livestock (bovine and swine).. Vet World 2017 Jun;10(6):598-604.
      doi: 10.14202/vetworld.2017.598-604pubmed: 28717309google scholar: lookup
    12. Hong S, Rovira A, Davies P, Ahlstrom C, Muellner P, Rendahl A, Olsen K, Bender JB, Wells S, Perez A, Alvarez J. Serotypes and Antimicrobial Resistance in Salmonella enterica Recovered from Clinical Samples from Cattle and Swine in Minnesota, 2006 to 2015.. PLoS One 2016;11(12):e0168016.
      doi: 10.1371/journal.pone.0168016pubmed: 27936204google scholar: lookup
    13. Crump JA, Sjölund-Karlsson M, Gordon MA, Parry CM. Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections.. Clin Microbiol Rev 2015 Oct;28(4):901-37.
      doi: 10.1128/CMR.00002-15pubmed: 26180063google scholar: lookup
    14. Johnson TJ, Singer RS, Isaacson RE, Danzeisen JL, Lang K, Kobluk K, Rivet B, Borewicz K, Frye JG, Englen M, Anderson J, Davies PR. In Vivo Transmission of an IncA/C Plasmid in Escherichia coli Depends on Tetracycline Concentration, and Acquisition of the Plasmid Results in a Variable Cost of Fitness.. Appl Environ Microbiol 2015 May 15;81(10):3561-70.
      doi: 10.1128/AEM.04193-14pubmed: 25769824google scholar: lookup
    15. Stull JW, Weese JS. Hospital-associated infections in small animal practice.. Vet Clin North Am Small Anim Pract 2015 Mar;45(2):217-33, v.
      doi: 10.1016/j.cvsm.2014.11.009pubmed: 25559054google scholar: lookup
    16. Kanwar N, Scott HM, Norby B, Loneragan GH, Vinasco J, McGowan M, Cottell JL, Chengappa MM, Bai J, Boerlin P. Effects of ceftiofur and chlortetracycline treatment strategies on antimicrobial susceptibility and on tet(A), tet(B), and bla CMY-2 resistance genes among E. coli isolated from the feces of feedlot cattle.. PLoS One 2013;8(11):e80575.
      doi: 10.1371/journal.pone.0080575pubmed: 24260423google scholar: lookup
    17. Frye JG, Jackson CR. Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and Enteroccocus spp. isolated from U.S. food animals.. Front Microbiol 2013;4:135.
      doi: 10.3389/fmicb.2013.00135pubmed: 23734150google scholar: lookup
    18. Hu H, Wang C, Guo X, Li W, Wang Y, He Q. Broad activity against porcine bacterial pathogens displayed by two insect antimicrobial peptides moricin and cecropin B.. Mol Cells 2013 Feb;35(2):106-14.
      doi: 10.1007/s10059-013-2132-0pubmed: 23456332google scholar: lookup
    19. Glenn LM, Lindsey RL, Folster JP, Pecic G, Boerlin P, Gilmour MW, Harbottle H, Zhao S, McDermott PF, Fedorka-Cray PJ, Frye JG. Antimicrobial resistance genes in multidrug-resistant Salmonella enterica isolated from animals, retail meats, and humans in the United States and Canada.. Microb Drug Resist 2013 Jun;19(3):175-84.
      doi: 10.1089/mdr.2012.0177pubmed: 23350745google scholar: lookup
    20. Islam MA, Talukdar PK, Hoque A, Huq M, Nabi A, Ahmed D, Talukder KA, Pietroni MA, Hays JP, Cravioto A, Endtz HP. Emergence of multidrug-resistant NDM-1-producing Gram-negative bacteria in Bangladesh.. Eur J Clin Microbiol Infect Dis 2012 Oct;31(10):2593-600.
      doi: 10.1007/s10096-012-1601-2pubmed: 22422273google scholar: lookup
    21. Schmidt JW, Brichta-Harhay DM, Kalchayanand N, Bosilevac JM, Shackelford SD, Wheeler TL, Koohmaraie M. Prevalence, enumeration, serotypes, and antimicrobial resistance phenotypes of salmonella enterica isolates from carcasses at two large United States pork processing plants.. Appl Environ Microbiol 2012 Apr;78(8):2716-26.
      doi: 10.1128/AEM.07015-11pubmed: 22327585google scholar: lookup
    22. Martin LC, Weir EK, Poppe C, Reid-Smith RJ, Boerlin P. Characterization of blaCMY-2 plasmids in Salmonella and Escherichia coli isolates from food animals in Canada.. Appl Environ Microbiol 2012 Feb;78(4):1285-7.
      doi: 10.1128/AEM.06498-11pubmed: 22156427google scholar: lookup
    23. Fernández-Alarcón C, Singer RS, Johnson TJ. Comparative genomics of multidrug resistance-encoding IncA/C plasmids from commensal and pathogenic Escherichia coli from multiple animal sources.. PLoS One 2011;6(8):e23415.
      doi: 10.1371/journal.pone.0023415pubmed: 21858108google scholar: lookup
    24. Welch TJ, Evenhuis J, White DG, McDermott PF, Harbottle H, Miller RA, Griffin M, Wise D. IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri.. Antimicrob Agents Chemother 2009 Feb;53(2):845-6.
      doi: 10.1128/AAC.01312-08pubmed: 19029319google scholar: lookup
    25. Guard-Bouldin J, Morales CA, Frye JG, Gast RK, Musgrove M. Detection of Salmonella enterica subpopulations by phenotype microarray antibiotic resistance patterns.. Appl Environ Microbiol 2007 Dec;73(23):7753-6.
      doi: 10.1128/AEM.01228-07pubmed: 17965201google scholar: lookup
    Subscribe to our newsletter
    Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.