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Home / Equine Research Bank / Animals (Basel) / Prevalence of Chronic Progressive Lymphedema in the Rhenish ...
Animals : an open access journal from MDPI2023; 13(6); 999; doi: 10.3390/ani13060999

Prevalence of Chronic Progressive Lymphedema in the Rhenish German Draught Horse.

Abstract: Chronic progressive lymphedema (CPL) is a common disease in Rhenisch German draught horses. The objective of our study was to evaluate the prevalence of this disease and its progression with age in 493 Rhenish German draught horses from different regions in Germany. We employed generalized linear models with binomial, multinomial, and normal distributions to analyse the effects of breeding association, coat colour, sex and age within sex, time of examination, limb on which CPL was recorded, and farm-related factors on disease scores. The occurrence and severity of CPL were significantly influenced by breeding area, sex, coat colour, and interaction of age by sex. Males had significantly higher CPL-scores than geldings (1.92-fold) and females (5.02-fold) as well as a faster (1.85-fold) disease progression per year of life than females (1.44-fold) and geldings (1.25-fold). Regression on age within sex was still significant when age was restricted to a minimum of 7 years in the analysis. Bay horses exhibited 1.77-fold and 2.19-fold higher CPL-scores than chestnut and black horses. Keeping horses on pasture and keeping bedding clean reduced CPL-scores, whereas feeding of hay silage and concentrates during winter increased CPL-scores. Our analysis revealed significant regression coefficients of cannon bone circumference on CPL-scores. Relationships with hoof measures and skinfold diameter at the neck were not found. In conclusion, differences among breeding districts and sexes by age had the largest impact on CPL prevalence and scores. Disease progression was evident up to a mean age of 16 years in males and 20 years in females. The identification of risk factors and their effects on CPL should help to reduce the occurrence and progression of CPL.
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Publication Date: 2023-03-09 PubMed ID: 36978540PubMed Central: PMC10044062DOI: 10.3390/ani13060999Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article is about a study determining the presence and progression of a disease known as chronic progressive lymphedema, mainly affecting Rhenish German draught horses, and identifying the various factors influencing its development and progression.

Objective and Method

  • The primary objective of this study is to analyse the prevalence and age-related progression of Chronic Progressive Lymphedema (CPL), a disease common in Rhenish German draught horses. The researchers collected data from 493 subjects scattered across various areas in Germany.
  • Generalized linear models considering binomial, multinomial, and normal distributions have been utilized for data analysis. The variable factors explored included the horse’s breeding association, coat colour, sex, the limb affected by CPL, age broken down by sex, timing of examination, and a range of farm-related considerations.

Results and Conclusions

  • Based on their analysis, the occurrence and severity of CPL is significantly affected by factors such as breeding area, sex, coat color, and an interplay between the age and sex of the horses.
  • Male horses were found to have higher CPL-scores (indicating disease prevalence) compared to geldings (castrated horses) and females. Also, males showed faster disease progression per year lived than females and geldings.
  • In terms of coat color, Bay horses revealed higher CPL-scores than chestnut and black horses.
  • The researchers identified specific husbandry conditions that influenced CPL scores. Horse’s kept on pasture and with clean bedding resulted in reduced CPL-scores, whereas the feeding of hay silage and concentrates during the winter correlated with increased CPL-scores.
  • The study also established a significant correlation between cannon bone circumference and CPL-scores but found no relationship with hoof measurements and skinfold diameter at the neck.
  • The researchers concluded that variations among breeding districts and sex-to-age interactions had the most significant impact on CPL’s prevalence and scores. The disease progression appeared to continue until a mean age of 16 years in males and 20 years in females.
  • The identification of various risk factors contributing to CPL prevalence and their impacts can possibly help in developing effective strategies to mitigate the disease occurrence and progression.

Cite This Article

APA
Sievers J, Distl O. (2023). Prevalence of Chronic Progressive Lymphedema in the Rhenish German Draught Horse. Animals (Basel), 13(6), 999. https://doi.org/10.3390/ani13060999

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 13
Issue: 6
PII: 999

Researcher Affiliations

Sievers, Johanna
  • Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.
Distl, Ottmar
  • Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover (Foundation), 30559 Hannover, Germany.

Grant Funding

  • 17-02.04.01-14/2019. / Ministry for Environment, Agriculture, Conservation and Consumer Protection

Conflict of Interest Statement

The authors declare no conflict of interest. The funders had no role in the design of the study, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results.

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Citations

This article has been cited 1 times.
  1. Brys M, Claerebout E, Chiers K. Chronic Progressive Lymphedema in Belgian Draft Horses: Understanding and Managing a Challenging Disease.. Vet Sci 2023 May 12;10(5).
    doi: 10.3390/vetsci10050347pubmed: 37235431google scholar: lookup
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