Prevalence of equine herpesvirus type 1 strains of neuropathogenic genotype in a major breeding area of Japan.
Abstract: A single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 in the viral DNA polymerase gene (encoded by open reading frame [ORF] 30) of equine herpesvirus type 1 (EHV-1) has been significantly associated with neuropathogenic potential in strains of this virus. To estimate the prevalence of EHV-1 strains with the neuropathogenic genotype (ORF30 G(2254)) in the Hidaka district--a major horse breeding area in Japan--we analyzed the ORF30 genomic region in cases of EHV-1 infection in this area during the years 2001-2010. Of the 113 cases analyzed, 3 (2.7%) were induced by ORF30 G(2254) strains. This prevalence is lower than those observed in the U.S.A. (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%).
Publication Date: 2011-08-09 PubMed ID: 21828961DOI: 10.1292/jvms.11-0140Google Scholar: Lookup
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- Journal Article
Summary
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The research investigates the prevalence of neuropathogenic equine herpesvirus type 1 (EHV-1) strains in the Hidaka region of Japan. It shows that these strains were involved in 2.7% of EHV-1 infections between 2001 and 2010, which is a lower prevalence than reported in other countries.
Objective of the Research
- The primary objective of this research was to determine the prevalence of strains of equine herpesvirus type 1 (EHV-1) with a neuropathogenic genotype, specifically possessing a single non-synonymous nucleotide substitution of guanine (G) for adenine (A) at position 2254 within the viral DNA polymerase gene (encoded by open reading frame [ORF] 30). This substitution has been found to greatly enhance the neuropathogenic potential of EHV-1 strains. The place of study was the Hidaka district in Japan, a significant area for horse breeding.
Methodology of the Study
- Researchers studied cases of EHV-1 infection in the Hidaka region over a decade, from 2001 to 2010. They focused on analyzing the ORF30 genomic region where the aforementioned substitution occurs.
Main Findings
- From 113 cases of EHV-1 infection analyzed, the researchers found only 3 cases (or 2.7% of the total) to be induced by ORF30 G(2254) strains (neuropathogenic genotype). This suggests that the prevalence of neuropathogenic genotypes in the Hidaka region is relatively low.
- The prevalence rate in Hidaka is markedly lower when compared to observed rates in other countries, including the USA (10.8-19.4%), Argentina (7.4%), France (24%), and Germany (10.6%). This comparison adds context to the findings and highlights the relative rarity of the neuropathogenic genotype in this particular region of Japan.
Significance of the Research
- The findings provide important insights into the prevalence and geographical distribution of EHV-1 strains with the neuropathogenic genotype. Understanding this prevalence can guide appropriate preventative and treatment measures in areas of high horse breeding activity, such as Hidaka.
- By determining that neuropathogenic strains have a lower prevalence than previously expected, the study may contribute to updated infectious disease control strategies and health policies in the equine industry, catering to specific regional requirements.
Cite This Article
APA
Tsujimura K, Oyama T, Katayama Y, Muranaka M, Bannai H, Nemoto M, Yamanaka T, Kondo T, Kato M, Matsumura T.
(2011).
Prevalence of equine herpesvirus type 1 strains of neuropathogenic genotype in a major breeding area of Japan.
J Vet Med Sci, 73(12), 1663-1667.
https://doi.org/10.1292/jvms.11-0140 Publication
Researcher Affiliations
- Epizootic Research Center, Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi 329–0412, Japan. koji_tsujimura@jra.go.jp
MeSH Terms
- Abortion, Veterinary
- Animals
- Breeding
- Female
- Herpesviridae Infections / epidemiology
- Herpesviridae Infections / veterinary
- Herpesviridae Infections / virology
- Herpesvirus 1, Equid / genetics
- Herpesvirus 1, Equid / isolation & purification
- Horse Diseases / epidemiology
- Horse Diseases / virology
- Horses
- Japan / epidemiology
- Pregnancy
- Pregnancy Complications, Infectious
- Time Factors
Citations
This article has been cited 13 times.- Carvelli A, Nielsen SS, Paillot R, Broglia A, Kohnle L. Clinical impact, diagnosis and control of Equine Herpesvirus-1 infection in Europe.. EFSA J 2022 Apr;20(4):e07230.
- Tong P, Duan R, Palidan N, Deng H, Duan L, Ren M, Song X, Jia C, Tian S, Yang E, Kuang L, Xie J. Outbreak of neuropathogenic equid herpesvirus 1 causing abortions in Yili horses of Zhaosu, North Xinjiang, China.. BMC Vet Res 2022 Mar 1;18(1):83.
- Nielsen SS, Alvarez J, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortázar C, Herskin M, Michel V, Miranda Chueca MÁ, Roberts HC, Padalino B, Pasquali P, Spoolder H, Ståhl K, Calvo AV, Viltrop A, Winckler C, Carvelli A, Paillot R, Broglia A, Kohnle L, Baldinelli F, Van der Stede Y. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): infection with Equine Herpesvirus-1.. EFSA J 2022 Jan;20(1):e07036.
- Vereecke N, Carnet F, Pronost S, Vanschandevijl K, Theuns S, Nauwynck H. Genome Sequences of Equine Herpesvirus 1 Strains from a European Outbreak of Neurological Disorders Linked to a Horse Gathering in Valencia, Spain, in 2021.. Microbiol Resour Announc 2021 May 20;10(20).
- Kang HW, Lee EY, Lee KK, Ko MK, Park JY, Kim YH, Lee K, Choi EJ, Kim J, So B, Park CK, Jeoung HY. Evaluation of the Variability of the ORF34, ORF68, and MLST Genes in EHV-1 from South Korea.. Pathogens 2021 Apr 2;10(4).
- Oladunni FS, Horohov DW, Chambers TM. EHV-1: A Constant Threat to the Horse Industry.. Front Microbiol 2019;10:2668.
- Preziuso S, Sgorbini M, Marmorini P, Cuteri V. Equid alphaherpesvirus 1 from Italian Horses: Evaluation of the Variability of the ORF30, ORF33, ORF34 and ORF68 Genes.. Viruses 2019 Sep 13;11(9).
- Garvey M, Lyons R, Hector RD, Walsh C, Arkins S, Cullinane A. Molecular Characterisation of Equine Herpesvirus 1 Isolates from Cases of Abortion, Respiratory and Neurological Disease in Ireland between 1990 and 2017.. Pathogens 2019 Jan 15;8(1).
- Matczuk AK, Skarbek M, Jackulak NA, Bażanów BA. Molecular characterisation of equid alphaherpesvirus 1 strains isolated from aborted fetuses in Poland.. Virol J 2018 Dec 3;15(1):186.
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- Tsujimura K, Murase H, Bannai H, Nemoto M, Yamanaka T, Kondo T. Efficacy of five commercial disinfectants and one anionic surfactant against equine herpesvirus type 1.. J Vet Med Sci 2015 Nov;77(11):1545-8.
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