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BMC veterinary research2018; 14(1); 390; doi: 10.1186/s12917-018-1726-3

Prevalence of osteochondral lesions in the fetlock and hock joints of Standardbred horses that survived bacterial infection before 6 months of age.

Abstract: Young Standardbred horses frequently develop fragments in joints. Some fragments represent osteochondrosis; others are considered developmental, but it is uncertain whether they result from preceding osteochondrosis. Osteochondrosis occurs as a consequence of failure of the cartilage canal blood supply and ischaemic chondronecrosis. In heritably predisposed foals, failure was associated with incorporation of vessels into bone. However, bacterial vascular failure was also recently documented in foals suffering spontaneous infections, proving that bacteria can cause osteochondral lesions in foals up to 150 days old. The aim was to determine prevalence of fetlock and hock lesions at screening age in Standardbred horses that survived infections before 6 months of age, and compare this to prevalence reported in the literature. Methods: The material consisted of 28 Standardbred horses; 17 males and 11 females that presented and were diagnosed clinically with bacterial infections from 1 to 150 days of age (average: 41.3 days). A screening set of 8 radiographic projections was available from all 28 horses at 7-85 months of age (average: 23.6 months). Lesion prevalence was compared to three previously reported Standardbred cohorts. Results: Osteochondral lesions were detected in one or more joints of 19/28 horses (67.9%); in the fetlock joint of 14/28 horses (50%) and the hock joint of 11/28 horses (39.3%). These prevalences were ≥ 2 x higher than the corresponding prevalences in the comparison cohorts, and statistically significantly so in 5:6 comparisons (p-values from < 0.00001 to 0.01). In the sepsis cohort, there were an average of 2.3 affected joints and 2.5 lesions per affected horse, whereas there in the one comparable literature cohort were an average of 1.5 affected joints and 1.7 lesions per affected horse. Conclusions: Standardbred horses that survived bacterial infections before 6 months of age had more osteochondral lesions than literature comparison cohorts at screening age. The implication was that some of the lesions in this group were caused by bacteria. It may become necessary to develop methods for differentiating between acquired, septic and aseptic, heritably predisposed lesions.
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Publication Date: 2018-12-10 PubMed ID: 30526583PubMed Central: PMC6288956DOI: 10.1186/s12917-018-1726-3Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the prevalence of osteochondral lesions in the joints of young Standardbred horses that have survived bacterial infection from a very young age. The study finds that horses that lived through bacteria infections before they reach 6 months of age are more likely to develop osteochondral lesions.

Background

  • Osteochondrosis, a disorder that affects the growth of cartilage and bone, is often observed in young Standardbred horses and is linked to high incidences of joint fragments. Some of these fragments are developmental, while others indicate osteochondrosis.
  • A vascular supply failure to the cartilage, known as ischaemic chondronecrosis, is considered a consequence of osteochondrosis. In foals with a hereditary predisposition, this failure is linked to the incorporation of vessels into bones.
  • Bacterial vascular failure has also been documented in foals suffering spontaneous infections. This indicates that bacteria can cause osteochondral lesions and even injuries to the joints in foals up to 150 days old.

Objective and Methodology

  • The aim of this research was to determine the prevalence of fetlock and hock joint lesions at screening age in Standardbred horses that survived an infection before they reached 6 months of age and compare this to other reports in the literature.
  • The study involved 28 Standardbred horses diagnosed with bacterial infections at an average age of 41.3 days.
  • Screening sets of eight radiographic projections were used to observe the horses between the ages of seven and 85 months (average: 23.6 months).
  • The prevalence of lesions in the study subjects was compared to three other reported Standardbred cohorts.

Findings

  • Osteochondral lesions were found in one or more joints in 19 out of 28 horses studied.
  • Specifically, in the fetlock joint, lesions were present in 50% of the horses and in the hock joint, lesions were detected in 39.3% of the horses.
  • The prevalence of lesions observed was at least twice as high as those reported in other cohorts and was statistically significant in 5 out of 6 comparisons made.
  • In the cohort affected by sepsis, on average, there were 2.3 affected joints and 2.5 lesions per affected horse. A comparable literature cohort saw averages of 1.5 affected joints and 1.7 lesions per affected horse.

Conclusion

  • Standardbred horses that survived bacterial infections before they reached 6 months of age had a higher prevalence of osteochondral lesions compared to literature comparison cohorts at screening age.
  • This implies that bacterial infection can cause some of these lesions. There might be a need to develop methods to differentiate between lesions triggered by bacteria (septic) and those caused by inherited predisposition (aseptic).

Cite This Article

APA
Hendrickson EHS, Lykkjen S, Dolvik NI, Olstad K. (2018). Prevalence of osteochondral lesions in the fetlock and hock joints of Standardbred horses that survived bacterial infection before 6 months of age. BMC Vet Res, 14(1), 390. https://doi.org/10.1186/s12917-018-1726-3

Publication

BMC veterinary research
ISSN: 1746-6148
NlmUniqueID: 101249759
Country: England
Language: English
Volume: 14
Issue: 1
Pages: 390
PII: 390

Researcher Affiliations

Hendrickson, Eli H S
  • Equine Section, Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ullevålsveien 72, 0454, Oslo, Norway.
Lykkjen, Sigrid
  • Equine Section, Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ullevålsveien 72, 0454, Oslo, Norway.
Dolvik, Nils I
  • Equine Section, Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ullevålsveien 72, 0454, Oslo, Norway.
Olstad, Kristin
  • Equine Section, Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Ullevålsveien 72, 0454, Oslo, Norway. kristin.olstad@nmbu.no.

MeSH Terms

  • Age Factors
  • Animals
  • Bacterial Infections / complications
  • Bacterial Infections / microbiology
  • Bacterial Infections / pathology
  • Bacterial Infections / veterinary
  • Carpus, Animal / pathology
  • Female
  • Horse Diseases / microbiology
  • Horse Diseases / pathology
  • Horses
  • Male
  • Osteochondrosis / epidemiology
  • Osteochondrosis / etiology
  • Osteochondrosis / pathology
  • Osteochondrosis / veterinary
  • Prevalence
  • Tarsus, Animal / pathology

Grant Funding

  • 218962 / Norges Forskningsru00e5d (NO)
  • H1147117 / Swedish-Norwegian Foundation for Equine Research (Norsk Hestesenter, Jordbruksavtalen)

Conflict of Interest Statement

ETHICS APPROVAL: The study was carried out in accordance with the Norwegian Law on Animal Welfare (LOV-2009-06-19-97) and the Regulations for Use of Animals in Research (FOR-2015-06-18-761). Informed consent was obtained from the client or owner for all involved animals. Consent to participate from human subjects: not applicable. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

This article includes 50 references
  1. Carlson CS, Cullins LD, Meuten DJ. Osteochondrosis of the articular-epiphyseal cartilage complex in young horses: evidence for a defect in cartilage canal blood supply.. Vet Pathol 1995 Nov;32(6):641-7.
    doi: 10.1177/030098589503200605pubmed: 8592799google scholar: lookup
  2. Olstad K, Ytrehus B, Ekman S, Carlson CS, Dolvik NI. Epiphyseal cartilage canal blood supply to the tarsus of foals and relationship to osteochondrosis.. Equine Vet J 2008 Jan;40(1):30-9.
    doi: 10.2746/042516407X239836pubmed: 18083657google scholar: lookup
  3. Ytrehus B, Ekman S, Carlson CS, Teige J, Reinholt FP. Focal changes in blood supply during normal epiphyseal growth are central in the pathogenesis of osteochondrosis in pigs.. Bone 2004 Dec;35(6):1294-306.
    doi: 10.1016/j.bone.2004.08.016pubmed: 15589210google scholar: lookup
  4. Carlson CS, Meuten DJ, Richardson DC. Ischemic necrosis of cartilage in spontaneous and experimental lesions of osteochondrosis.. J Orthop Res 1991 May;9(3):317-29.
    doi: 10.1002/jor.1100090303pubmed: 2010836google scholar: lookup
  5. Olstad K, Hendrickson EH, Carlson CS, Ekman S, Dolvik NI. Transection of vessels in epiphyseal cartilage canals leads to osteochondrosis and osteochondrosis dissecans in the femoro-patellar joint of foals; a potential model of juvenile osteochondritis dissecans.. Osteoarthritis Cartilage 2013 May;21(5):730-8.
    doi: 10.1016/j.joca.2013.02.005pubmed: 23428601google scholar: lookup
  6. Ytrehus B, Carlson CS, Ekman S. Etiology and pathogenesis of osteochondrosis.. Vet Pathol 2007 Jul;44(4):429-48.
    doi: 10.1354/vp.44-4-429pubmed: 17606505google scholar: lookup
  7. Olstad K, Cnudde V, Masschaele B, Thomassen R, Dolvik NI. Micro-computed tomography of early lesions of osteochondrosis in the tarsus of foals.. Bone 2008 Sep;43(3):574-83.
    doi: 10.1016/j.bone.2008.04.024pubmed: 18579463google scholar: lookup
  8. Carlsten J, Sandgren B, Dalin G. Development of osteochondrosis in the tarsocrural joint and osteochondral fragments in the fetlock joints of Standardbred trotters. I A radiological survey.. Equine Vet J Suppl 1993;16:42–47.
  9. Dik KJ, Enzerink E, van Weeren PR. Radiographic development of osteochondral abnormalities, in the hock and stifle of Dutch Warmblood foals, from age 1 to 11 months.. Equine Vet J Suppl 1999 Nov;(31):9-15.
    doi: 10.1111/j.2042-3306.1999.tb05308.xpubmed: 10999655google scholar: lookup
  10. Olstad K, Ytrehus B, Ekman S, Carlson CS, Dolvik NI. Early lesions of osteochondrosis in the distal tibia of foals.. J Orthop Res 2007 Aug;25(8):1094-105.
    doi: 10.1002/jor.20375pubmed: 17415757google scholar: lookup
  11. McIlwraith CW. Inferences from referred clinical cases of osteochondritis dissecans.. Equine Vet J Suppl 1993;16:27–30.
  12. Yovich JV, McIlwraith CW, Stashak TS. Osteochondritis dissecans of the sagittal ridge of the third metacarpal and metatarsal bones in horses.. J Am Vet Med Assoc 1985 Jun 1;186(11):1186-91.
    pubmed: 4008298
  13. Houttu J. Arthroscopic removal of osteochondral fragments of the palmar/plantar aspect of the metacarpo/metatarsophalangeal joints.. Equine Vet J 1991 May;23(3):163-5.
    doi: 10.1111/j.2042-3306.1991.tb02747.xpubmed: 1884695google scholar: lookup
  14. Birkeland R. Chip fractures of the first phalanx in the metatarso-phalangeal joint of the horse.. Acta Radiol Suppl 1972;319:73-7.
    doi: 10.3109/05678067209173997pubmed: 4531211google scholar: lookup
  15. Bukowiecki CF, Bramlage LR, Gabel AA. Palmar/plantar process fractures of the proximal phalanx in 15 horses.. Vet Surg 1986;15(5):383–388.
    doi: 10.1111/j.1532-950X.1986.tb00248.xgoogle scholar: lookup
  16. Dalin G, Sandgren B, Carlsten J. Plantar osteochondral fragments in the metatarsophalangeal joints of Standardbred trotters; result of osteochondrosis or trauma?. Equine Vet J Suppl 1993;16:62–65.
  17. Grøndahl AM, Dolvik NI. Heritability estimations of osteochondrosis in the tibiotarsal joint and of bony fragments in the palmar/plantar portion of the metacarpo- and metatarsophalangeal joints of horses.. J Am Vet Med Assoc 1993 Jul 1;203(1):101-4.
    pubmed: 8407439
  18. Hilla D, Distl O. Heritabilities and genetic correlations between fetlock, hock and stifle osteochondrosis and fetlock osteochondral fragments in Hanoverian Warmblood horses.. J Anim Breed Genet 2014 Feb;131(1):71-81.
    doi: 10.1111/jbg.12062pubmed: 24236645google scholar: lookup
  19. van Grevenhof EM, Schurink A, Ducro BJ, van Weeren PR, van Tartwijk JM, Bijma P, van Arendonk JA. Genetic variables of various manifestations of osteochondrosis and their correlations between and within joints in Dutch warmblood horses.. J Anim Sci 2009 Jun;87(6):1906-12.
    pubmed: 19213707doi: 10.2527/jas.2008-1199google scholar: lookup
  20. Denecke R, Trautwein G, Kaup FJ. The role of cartilage canals in the pathogenesis of experimentally induced polyarthritis.. Rheumatol Int 1986;6(6):239-43.
    doi: 10.1007/BF00541313pubmed: 3809886google scholar: lookup
  21. Jensen HE, Nielsen OL, Agerholm JS, Iburg T, Johansen LK, Johannesson E, Møller M, Jahn L, Munk L, Aalbaek B, Leifsson PS. A non-traumatic Staphylococcus aureus osteomyelitis model in pigs.. In Vivo 2010 May-Jun;24(3):257-64.
    pubmed: 20554996
  22. Speers DJ, Nade SM. Ultrastructural studies of adherence of Staphylococcus aureus in experimental acute hematogenous osteomyelitis.. Infect Immun 1985 Aug;49(2):443-6.
    pmc: PMC262038pubmed: 4018875doi: 10.1128/iai.49.2.443-446.1985google scholar: lookup
  23. Emslie KR, Nade S. Acute hematogenous staphylococcal osteomyelitis. A description of the natural history in an avian model.. Am J Pathol 1983 Mar;110(3):333-45.
    pmc: PMC1916166pubmed: 6829712
  24. Wideman RF Jr. Bacterial chondronecrosis with osteomyelitis and lameness in broilers: a review.. Poult Sci 2016 Feb;95(2):325-44.
    doi: 10.3382/ps/pev320pubmed: 26527707google scholar: lookup
  25. Wormstrand B, Østevik L, Ekman S, Olstad K. Septic Arthritis/Osteomyelitis May Lead to Osteochondrosis-Like Lesions in Foals.. Vet Pathol 2018 Sep;55(5):693-702.
    doi: 10.1177/0300985818777786pubmed: 29807507google scholar: lookup
  26. . The Frequency and Heredity of Navicular Disease, Sesamoidosis, Fetlock Joint Arthrosis, Bone Spavin, Osteochondrosis of the Hock: A Radiographic Progeny Study.. 1994: 1–47.
  27. Van Grevenhof EM, Ducro BJ, Van Weeren PR, Van Tartwijk JM, Van den Belt AJ, Bijma P. Prevalence of various radiographic manifestations of osteochondrosis and their correlations between and within joints in Dutch warmblood horses.. Equine Vet J 2009 Jan;41(1):11-6.
    doi: 10.2746/042516408X334794pubmed: 19301576google scholar: lookup
  28. Olsen HF, Meuwissen T, Klemetsdal G. Optimal contribution selection applied to the Norwegian and the North-Swedish cold-blooded trotter - a feasibility study.. J Anim Breed Genet 2013 Jun;130(3):170-7.
    doi: 10.1111/j.1439-0388.2012.01005.xpubmed: 23679942google scholar: lookup
  29. Brewer BD, Koterba AM. Development of a scoring system for the early diagnosis of equine neonatal sepsis.. Equine Vet J 1988 Jan;20(1):18-22.
    doi: 10.1111/j.2042-3306.1988.tb01445.xpubmed: 3366100google scholar: lookup
  30. Lykkjen S, Roed KH, Dolvik NI. Osteochondrosis and osteochondral fragments in Standardbred trotters: prevalence and relationships.. Equine Vet J 2012 May;44(3):332-8.
    doi: 10.1111/j.2042-3306.2011.00434.xpubmed: 21895752google scholar: lookup
  31. Philipsson J, Andréasson E, Sandgren B, Dalin G, Carlsten J. Osteochondrosis in the tarsocrural joint and osteochondral fragments in the fetlock joints in Standardbred trotters. II Heritability.. Equine Vet J Suppl 1993;16:38–41.
    doi: 10.1111/j.2042-3306.1993.tb04852.xgoogle scholar: lookup
  32. Etterlin PE, Morrison DA, Österberg J, Ytrehus B, Heldmer E, Ekman S. Osteochondrosis, but not lameness, is more frequent among free-range pigs than confined herd-mates.. Acta Vet Scand 2015 Sep 29;57:63.
    doi: 10.1186/s13028-015-0154-7pmc: PMC4587880pubmed: 26416598google scholar: lookup
  33. Savage CJ, McCarthy RN, Jeffcott LB. Effects of dietary energy and protein on induction of dyschondroplasia in foals.. Equine Vet J Suppl 1993;16:74–79.
  34. Glade MJ, Belling TH Jr. Growth plate cartilage metabolism, morphology and biochemical composition in over- and underfed horses.. Growth 1984 Winter;48(4):473-82.
    pubmed: 6532905
  35. van Weeren PR, Barneveld A. The effect of exercise on the distribution and manifestation of osteochondrotic lesions in the Warmblood foal.. Equine Vet J Suppl 1999 Nov;(31):16-25.
    pubmed: 10999656doi: 10.1111/j.2042-3306.1999.tb05309.xgoogle scholar: lookup
  36. Hance SR, Schneider RK, Embertson RM, Bramlage LR, Wicks JR. Lesions of the caudal aspect of the femoral condyles in foals: 20 cases (1980-1990).. J Am Vet Med Assoc 1993 Feb 15;202(4):637-46.
    pubmed: 8449810
  37. Haggett EF, Foote AK, Head MJ, McGladdery AJ, Powell SE. Necrosis of the femoral condyles in a four-week-old foal: clinical, imaging and histopathological features.. Equine Vet J Suppl 2012 Feb;(41):91-5.
    pubmed: 22594034doi: 10.1111/j.2042-3306.2011.00498.xgoogle scholar: lookup
  38. Olstad K, Ytrehus B, Ekman S, Carlson CS, Dolvik NI. Epiphyseal cartilage canal blood supply to the distal femur of foals.. Equine Vet J 2008 Jul;40(5):433-9.
    doi: 10.2746/042516408X300269pubmed: 18487109google scholar: lookup
  39. Olstad K, Ytrehus B, Ekman S, Carlson CS, Dolvik NI. Epiphyseal cartilage canal blood supply to the metatarsophalangeal joint of foals.. Equine Vet J 2009 Dec;41(9):865-71.
    doi: 10.2746/042516409X437762pubmed: 20383983google scholar: lookup
  40. Hellings IR, Ekman S, Hultenby K, Dolvik NI, Olstad K. Discontinuities in the endothelium of epiphyseal cartilage canals and relevance to joint disease in foals.. J Anat 2016 Jan;228(1):162-75.
    doi: 10.1111/joa.12391pmc: PMC4694163pubmed: 26471892google scholar: lookup
  41. Hellings IR, Dolvik NI, Ekman S, Olstad K. Cartilage canals in the distal intermediate ridge of the tibia of fetuses and foals are surrounded by different types of collagen.. J Anat 2017 Oct;231(4):615-625.
    doi: 10.1111/joa.12650pmc: PMC5603784pubmed: 28620929google scholar: lookup
  42. Finnøy A, Olstad K, Lilledahl MB. Non-linear optical microscopy of cartilage canals in the distal femur of young pigs may reveal the cause of articular osteochondrosis.. BMC Vet Res 2017 Aug 22;13(1):270.
    doi: 10.1186/s12917-017-1197-ypmc: PMC5568222pubmed: 28830435google scholar: lookup
  43. Olstad K, Kongsro J, Grindflek E, Dolvik NI. Consequences of the natural course of articular osteochondrosis in pigs for the suitability of computed tomography as a screening tool.. BMC Vet Res 2014 Sep 9;10:212.
    doi: 10.1186/s12917-014-0212-9pmc: PMC4172834pubmed: 25199991google scholar: lookup
  44. Olstad K, Ekman S, Carlson CS. An Update on the Pathogenesis of Osteochondrosis.. Vet Pathol 2015 Sep;52(5):785-802.
    doi: 10.1177/0300985815588778pubmed: 26080832google scholar: lookup
  45. Chagnot C, Listrat A, Astruc T, Desvaux M. Bacterial adhesion to animal tissues: protein determinants for recognition of extracellular matrix components.. Cell Microbiol 2012 Nov;14(11):1687-96.
    doi: 10.1111/cmi.12002pubmed: 22882798google scholar: lookup
  46. Alderson M, Speers D, Emslie K, Nade S. Acute haematogenous osteomyelitis and septic arthritis--a single disease. An hypothesis based upon the presence of transphyseal blood vessels.. J Bone Joint Surg Br 1986 Mar;68(2):268-74.
    pubmed: 3958014doi: 10.1302/0301-620x.68b2.3958014google scholar: lookup
  47. Razakandrainibe R, Combes V, Grau GE, Jambou R. Crossing the wall: the opening of endothelial cell junctions during infectious diseases.. Int J Biochem Cell Biol 2013 Jul;45(7):1165-73.
    doi: 10.1016/j.biocel.2013.03.010pubmed: 23538297google scholar: lookup
  48. van Weeren PR. Osteochondrosis: developmental disorder or disorderly development?. 2004; pp. 164–175.
  49. Olstad K, Ytrehus B, Ekman S, Carlson CS, Dolvik NI. Early lesions of articular osteochondrosis in the distal femur of foals.. Vet Pathol 2011 Nov;48(6):1165-75.
    doi: 10.1177/0300985811398250pubmed: 21321104google scholar: lookup
  50. Olstad K, Østevik L, Carlson CS, Ekman S. Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses.. Vet Pathol 2015 Sep;52(5):862-72.
    doi: 10.1177/0300985814559399pubmed: 25428408google scholar: lookup

Citations

This article has been cited 5 times.
  1. Olstad K, Gangsei LE, Kongsro J. A method for labelling lesions for machine learning and some new observations on osteochondrosis in computed tomographic scans of four pig joints. BMC Vet Res 2022 Aug 31;18(1):328.
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  2. Olstad K, Wormstrand B, Kongsro J, Grindflek E. Computed tomographic development of physeal osteochondrosis in pigs. BMC Vet Res 2019 Dec 17;15(1):454.
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