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Prokinetic effects of cisapride, naloxone and parasympathetic stimulation at the equine ileo-caeco-colonic junction.
Abstract: The electromyogram of the terminal ileum, the caecum and the proximal right ventral colon was recorded in fasted conscious ponies receiving intravenously equiactive doses of pilocarpine (0.05 mg/kg) and carbachol (0.01 mg/kg) as acetylcholine analogues; cisapride (0.1 mg/kg) and metoclopramide (2 mg/kg) facilitating acetylcholine release from myenteric neurones and naloxone (0.05 mg/kg) as an antagonist of the endogenous inhibitory opioid system. Both cisapride and naloxone induced typical migrating spike bursts in the colon associated with contractions of caecal body and caecal base. Both pilocarpine and carbachol stimulated the terminal ileum but had opposite effects on the activity of the caeco-colonic segment which was decreased by pilocarpine and increased by carbachol. High doses of metoclopramide had weak and unspecific stimulatory motor effects. It is concluded that a true prokinetic effect at the equine ileo-caeco-colonic junction requires a motor profile which includes coordination between contractions sequentially involving the body and the base of the caecum and migrating spike bursts on the proximal colon. Such changes in the motor profile were produced by cisapride and naloxone and to a lesser extent by carbachol.
Publication Date: 1988-12-01 PubMed ID: 3210259DOI: 10.1111/j.1365-2885.1988.tb00191.xGoogle Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study examines the effects of different drugs and chemical compounds on the movement of the ileo-caeco-colonic junction in horses. The results indicate that cisapride and naloxone stimulate productive movements in this area, while the effects of other tested substances vary.
Research Methodology
In this study, the researchers recorded the electromyogram (a record of the electrical activity of muscles) of the terminal ileum, the caecum, and the proximal right ventral colon of fasted, conscious ponies. These horses received equiactive doses of several substances including:
- pilocarpine and carbachol, both analogues of acetylcholine (a neurotransmitter that helps pass signals in the nervous system),
- cisapride and metoclopramide, both stimulants for acetylcholine release from myenteric neurons (nerve cells located in the gastrointestinal tract),
- naloxone, an antagonist of the endogenous inhibitory opioid system (it blocks the opioid receptors and is often used to treat opioid overdoses).
Findings
The study found that cisapride and naloxone induced typical migrating spike bursts (periods of intense muscle activity) in the colon. These were associated with contractions of the body and the base of the horses’ caecum (the first section of the large intestine).
Both pilocarpine and carbachol stimulated the terminal ileum (the final section of the small intestine) but had contrasting effects on the caeco-colonic segment: pilocarpine decreased its activity, while carbachol increased it.
High doses of metoclopramide showed weak and non-specific stimulatory motor effects.
Conclusion
The research concluded that for a true prokinetic effect (that enhances gastrointestinal motility) at the equine ileo-caeco-colonic junction, a motor profile involving coordination between contractions of the body and base of the caecum and migrating spike bursts on the proximal colon is needed.
These changes in the motor profile were notably achieved by cisapride and naloxone. Carbachol promotion was lesser in comparison.
This points to potential courses of treatment for horses dealing with digestive health issues aimed at stimulating productive movement in the ileo-caeco-colonic junction.
Cite This Article
APA
Ruckebusch Y, Roger T.
(1988).
Prokinetic effects of cisapride, naloxone and parasympathetic stimulation at the equine ileo-caeco-colonic junction.
J Vet Pharmacol Ther, 11(4), 322-329.
https://doi.org/10.1111/j.1365-2885.1988.tb00191.x Publication
Researcher Affiliations
- Department of Physiology, National Veterinary School, Toulouse, France.
MeSH Terms
- Animals
- Carbachol / administration & dosage
- Carbachol / pharmacology
- Cecum / drug effects
- Cisapride
- Colon / drug effects
- Gastrointestinal Motility / drug effects
- Horses / physiology
- Ileum / drug effects
- Injections, Intravenous
- Metoclopramide / administration & dosage
- Metoclopramide / pharmacology
- Naloxone / administration & dosage
- Naloxone / pharmacology
- Parasympathomimetics / administration & dosage
- Parasympathomimetics / pharmacology
- Pilocarpine / administration & dosage
- Pilocarpine / pharmacology
- Piperidines / administration & dosage
- Piperidines / pharmacology
Citations
This article has been cited 3 times.- Steinebach MA, Cole D. Use of cisapride in the resolution of pelvic flexure impaction in a horse. Can Vet J 1995 Oct;36(10):624-5.
- Roger T, Bardon T, Ruckebusch Y. Comparative effects of mu and kappa opiate agonists on the cecocolic motility in the pony. Can J Vet Res 1994 Jul;58(3):163-6.
- Dowling PM. Prokinetic drugs: metoclopramide and cisapride. Can Vet J 1995 Feb;36(2):115-6.
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