Analyze Diet
Frontiers in veterinary science2018; 5; 235; doi: 10.3389/fvets.2018.00235

Prolonged Recovery From General Anesthesia Possibly Related to Persistent Hypoxemia in a Draft Horse.

Abstract: Horses are susceptible to developing large areas of pulmonary atelectasis during recumbency and anesthesia. The subsequent pulmonary shunt is responsible for significant impairment of oxygenation. Since ventilation perfusion mismatch persists into the post-operative period, hypoxemia remains an important concern in the recovery stall. This case report describes the diagnosis and supportive therapy of persistent hypoxemia in a 914 kg draft horse after isoflurane anesthesia. It highlights how challenging it can be to deal with hypoxemia after disconnection from the anesthesia machine and how life-threatening it can become if refractory to treatment. Furthermore, it stresses the point on the interactions between hypoxemia and other factors, such as residual drug effects and hypothermia, that should also be considered in the case of delayed recovery from general anesthesia.
Publication Date: 2018-10-01 PubMed ID: 30327770PubMed Central: PMC6174201DOI: 10.3389/fvets.2018.00235Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Case Reports
  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article outlines the challenges in treating hypoxemia, a deficiency in the amount of oxygen reaching tissues, in a draft horse following isoflurane anesthesia, with in-depth coverage of the diagnosis process and the subsequent treatment measures.

Research Background and Purpose

  • The study is a case report based on a draft horse (weighing 914 kg) that underwent isoflurane anesthesia.
  • The primary focus is on the issue of persistent hypoxemia, i.e., deficiency in the amount of oxygen reaching the tissues, following the disconnection from the anesthesia machine.
  • The research underlines the complexities of handling post-anesthesia hypoxemia and the dangers if it proves resistant to treatment.
  • Additionally, it emphasizes how hypoxemia and other factors such as residual drug effects and hypothermia may fuse, complicating the recovery from general anesthesia.

Pulmonary Atelectasis and Anesthesia

  • The study states that horses are susceptible to developing large areas of lung tissue collapse known as pulmonary atelectasis during anesthesia or during laying down on the side (recumbency).
  • This collapse of lung tissue contributes to creating a pulmonary shunt, causing a substantial impairment of oxygenation, leading to hypoxemia.
  • It’s this ventilation-perfusion mismatch that remains into the post-operative phase making hypoxemia a significant concern after the anesthesia process.

Treatment and Challenges

  • The article provides a detailed account of diagnosing persistent hypoxemia and the supportive procedures taken to treat it.
  • It emphasizes the life-threatening risk if hypoxemia becomes resistant to treatment after anesthesia.
  • The research indicates that the interaction of hypoxemia with residual drug effects and hypothermia can hamper or delay recovery.
  • The complexities illuminated in the report emphasize the need for careful post-operative handling of horses post-anesthesia, particularly when they show signs of persistent hypoxemia.

Cite This Article

APA
Dupont J, Serteyn D, Sandersen C. (2018). Prolonged Recovery From General Anesthesia Possibly Related to Persistent Hypoxemia in a Draft Horse. Front Vet Sci, 5, 235. https://doi.org/10.3389/fvets.2018.00235

Publication

ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 5
Pages: 235

Researcher Affiliations

Dupont, Julien
  • Department of Clinical Sciences, Anesthesiology and Equine Surgery, Faculty of Veterinary Medicine, University of Liege, Liège, Belgium.
Serteyn, Didier
  • Department of Clinical Sciences, Anesthesiology and Equine Surgery, Faculty of Veterinary Medicine, University of Liege, Liège, Belgium.
Sandersen, Charlotte
  • Department of Clinical Sciences, Anesthesiology and Equine Surgery, Faculty of Veterinary Medicine, University of Liege, Liège, Belgium.

References

This article includes 56 references
  1. Hall LW. Disturbances of cardiopulmonary function in anesthetized horses.. Equine Vet J (1971) 3:95–8.
  2. McDonnell WN, Hall LW, Jeffcott LB. Radiographic evidence of impaired pulmonary function in laterally recumbent anaesthetized horses.. Equine Vet J (1979) 11:24–32.
  3. Dobson A, Gleed RD, Meyer RE, Stewart BJ. Changes in blood flow distribution in equine lungs induced by anaesthesia.. Q J Exp Physiol (1985) 70:283–97.
  4. Nyman G, Funkquist B, Kvart C, Frostell C, Tokics L, Strandberg A. Atelectasis causes gas exchange impairment in the anaesthetised horse.. Equine Vet J (1990) 22:317–24.
  5. Sorenson PR, Robinson NE. Postural effects on lung volumes and asynchronous ventilation in anaesthetized horses.. J Appl Physiol (1980) 48:97–103.
    doi: 10.1152/jappl.1980.48.1.97pubmed: 7353982google scholar: lookup
  6. Nyman G, Hedenstierna G. Ventilation-perfusion relationships in the anaesthetised horse.. Equine Vet J (1989) 21:274–81.
  7. Moens Y, Lagerweij E, Gootjes P, Poortman J. Distribution of inspired gas to each lung in the anaesthetised horse and influence of body shape.. Equine Vet J (1995) 27:110–6.
  8. Mansel JC, Clutton RE. The influence of body mass and thoracic dimensions on arterial oxygenation in anaesthetized horses and ponies.. Vet Anaesth Anal (2008) 35:392–9.
  9. Schauvliege S, Savvast I, Gasthuys F. The effect of the inspired oxygen fraction on arterial blood oxygenation in spontaneously breathing, isoflurane anaesthetized horses: a retrospective study.. Vet Anaest Analg (2015) 42:280–5.
    doi: 10.1111/vaa.12208pubmed: 25039320google scholar: lookup
  10. Hlastala MP, Bernard SL, Erickson HH, Fedde MR, Gaughan EM, McMurphy R. Pulmonary blood flow distribution in standing horses is not dominated by gravity.. J Appl Physiol (1996) 81:1051–61.
    doi: 10.1152/jappl.1996.81.3.1051pubmed: 8889734google scholar: lookup
  11. Stack A, Derksen FJ, Williams KJ, Robinson NE, Jackson WF. Lung region and racing affect mechanical properties of equine pulmonary microvasculature.. J Appl Physiol (2014) 117:370–6.
  12. Steffey EP, Wheat JD, Meagher DM, Norrie RD, McKee J, Brown M. Body position and mode of ventilation influences arterial pH, oxygen, and carbon dioxide tensions in halothane- anesthetized horses.. Am J Vet Res (1977) 38:379–82.
    pubmed: 15488
  13. Hall LW, Gillespie JR, Tyler WS. Alveolo-arearterial oxygen tension differences in anaesthetised horses.. Br J Anaesth (1968) 40:560–8.
    doi: 10.1093/bja/40.8.560pubmed: 4875426google scholar: lookup
  14. Mitchell B, Littlejohn A. The effect of anaesthesia and posture on the exchange of respiratory gases and on the heart rate.. Equine Vet J (1974) 6:177–8.
  15. Stegmann GF, Littlejohn A. The effect of lateral and dorsal recumbency on cardiopulmonary function in the anaesthetised horse.. J S Afr Vet Assoc (1987) 58:21–7.
    pubmed: 3112395
  16. Day TK, Gaynor JS, Muir WW, Bednarski RM, Mason DE. Blood gas values during intermittent positive pressure ventilation and spontaneous ventilation in 160 anesthetized horses positioned in lateral or dorsal recumbency.. Vet Surg (1995) 26:266–76.
  17. Mason DE, Muir WW, Wade A. Arterial blood gas tensions in the horse during recovery from anesthesia.. J Am Vet Med Assoc (1987) 190:989–94.
    pubmed: 3106274
  18. McMurphy RM, Cribb PH. Alleviation of post-anesthetic hypoxemia in the horse.. Can Vet J (1989) 30:37–41.
    pmc: PMC1680984pubmed: 17423205
  19. Mosing M, Waldmann AD, MacFarlane P, Iff S, Auer U, Bohm SH. Horses auto-recruit their lungs by inspiratory breath holding following recovery from general anaesthesia.. PLoS ONE (2016) 11:e0158080.
  20. Bettschart-Wolfensberger R. Horses.. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA. editors. Veterinary Anesthesia and Analgesia, The Fifth Edition of Lumb and Jones. Oxford, UK: Wiley Blackwell; (2015). p. 857–66..
  21. Hubbell JA, Kelly EM, Aarnes TK, Bednarski RM, Lerche P, Liu Z. Pharmacokinetics of midazolam after intravenous administration to horses.. Equine Vet J (2013) 45:721–5.
    doi: 10.1111/evj.12049pubmed: 23489241google scholar: lookup
  22. Fielding CL, Brumbaugh GW, Matthews NS, Peck KE, Roussel AJ. Pharmacokinetics and clinical effects of subanesthetic continuous rate infusion of ketamine in awake horses.. Am J Vet Res (2006) 67:1484–90.
    doi: 10.2460/ajvr.67.9.1484pubmed: 16948590google scholar: lookup
  23. Lankveld DP, Driessen B, Soma IR, Moate PJ, Rudy J, Uboh CE. Pharmacodynamic effects and pharmacokinetic profile of a long-term continuous rate infusion of racemic ketamine in healthy conscious horses.. J Vet Pharmacol Therap (2006) 29:477–88.
  24. Voulgaris DA, Hofmeister EH. Multivariate analysis of factors associated with post-anesthetic times to standing in isoflurane-anesthetized horses: 381 cases.. Vet Anaesth Analg (2009) 36:414–20.
  25. Tomasic M. Temporal changes in core body temperature in anesthetized adult horses.. Am J Vet Res (1999) 60:556–62.
    pubmed: 10328424
  26. Mayerhofer I, Scherzer S, Gabler C, van den Hoven R. Hypothermia in horses induces by general anaesthesia and limiting measures.. Equine Vet Educ (2005) 17:53–6.
  27. Clark-Price S. Inadvertent perianesthetic hypothermia in small animal patients.. Vet Clin Small Anim (2015) 45:983–94.
    doi: 10.1016/j.cvsm.2015.04.005pubmed: 26014270google scholar: lookup
  28. Araos JD, Larenza P, Boston R, De Monte V, De Marzo C, Grasso S. Use of oxygen content-based index, Fshunt, as an indicator of pulmonary venous admixture at various inspired oxygen fractions in anesthetized sheep.. Am J Vet Res (2012) 73:2013–20.
    doi: 10.2460/ajvr.73.12.2013pubmed: 23176433google scholar: lookup
  29. Kerr CL, McDonell WN. Oxygen supplementation and ventilatory support.. In: Muir WW, Hubbell JAE. editors. Equine Anesthesia: Monitoring and Emergency Therapy. St. Louis, MI: Saunders; (2009). p. 332–52..
  30. Benator SR, Hewlett AM, Nunn JF. The use of iso-shunt lines for control of oxygen therapy.. Br J Anaesth (1973) 45:711–8.
    doi: 10.1093/bja/45.7.711pubmed: 4581075google scholar: lookup
  31. Levionnois OL, Iff I, Moens Y. Successful treatment of hypoxemia by an alveolar recruitment maneuver in a horse during general anaesthesia for colic surgery.. Pferdeheilkunde (2006) 2:333–6.
    doi: 10.21836/PEM20060314google scholar: lookup
  32. Bringewatt T, Hopster K, Kästner SB, Rohn K, Ohnesorge B. Influence of modified open lung concept ventilation on the cardiovascular and pulmonary function of horses during total intravenous anaesthesia.. Vet Rec (2010) 167:1000–6.
    doi: 10.1136/vr.c4172pubmed: 21262730google scholar: lookup
  33. Hopster K, Kästner SB, Rohn K, Ohnesorge B. Intermittent positive pressure ventilation with constant positive end-expiratory pressure and alveolar recruitment manoeuvre during inhalation anaesthesia in horses undergoing surgery for colic, and its influence on the early recovery period.. Vet Anaesth Analg (2011) 38:169–77.
  34. Moens Y, Schrammel JP, Tusman G, Ambrisko TD, Solà J, Brunner JX. Variety of non-invasive continuous monitoring methodologies including electrical impedance tomography provides novel insights into the physiology of lung collapse and recruitment – case report of an anaesthetized horse.. Vet Anaesth Analg (2014) 41:196–204.
    doi: 10.1111/vaa.12098pubmed: 24734295google scholar: lookup
  35. Ambrisko TD, Schrammel J, Hopster K, Kästner S, Moens Y. Assessment of distribution of ventilation and regional lung compliance by electrical impedance tomography in anaesthetized horses undergoing alveolar recruitment manoeuvres.. Vet Anaesth Analg (2017) 44:264–72.
    doi: 10.1016/j.vaa.2016.03.001pubmed: 28237681google scholar: lookup
  36. Hopster K, Rohn K, Ohnesorge B, Kästner SB. Controlled mechanical ventilation with constant positive pressure and alveolar recruitment manouevres during anaesthesia in laterally or dorsally recumbent horses.. Vet Anaesth Analg (2017) 44:121–6.
    doi: 10.1111/vaa.12390pubmed: 27251105google scholar: lookup
  37. Wettstein D, Moens Y, Jaeggin-Schmucker N, Böhn SH, Rothen HU, Mosing M. Effects of an alveolar recruitment maneuver on cardiovascular and respiratory parameters during total intravenous anesthesia in ponies.. Am J Vet Res (2006) 67:152–9.
    doi: 10.2460/ajvr.67.1.152pubmed: 16426225google scholar: lookup
  38. Hospter K, Wogatzki A, Geburek F, Conze P, Kästner SB. Effects of positive end-expiratory pressure titration on intestinal oxygenation and perfusion in isoflurane anaesthetised horses.. Equine Vet J (2016) 49:250–256.
    doi: 10.1111/evj.12555pubmed: 26729233google scholar: lookup
  39. Hopster K, Jacobson B, Hopster-Iversen C, Rohn K, Kästner SB. Histopathological changes and mRNA expression in lungs of horses after inhalation anaesthesia with different ventilation strategies.. Res Vet Sci (2016) 107:8–15.
    doi: 10.1016/j.rvsc.2016.04.008pubmed: 27473968google scholar: lookup
  40. Eichenberger A, Proietti S, Wicky S, Magnusson L. Morbid obesity and postoperative pulmonary atelectasis: an underestimated problem.. Anesth Analg (2002) 95:1788–92.
  41. Smith DC, Crul JF. Early postoperative hypoxia during transport.. Br J Anaesth (1988) 61:625–7.
    pubmed: 3207535
  42. Moller JT, Wittrup M, Johansen SH. Hypoxemia in the post-anesthesia care unit: an observer study.. Anesthesiology (1990) 73:890–5.
  43. Hofmeister EH, Mackey EB, Trim CM. Effect of butorphanol administration on cardiovascular parameters in isoflurane-anesthetized horses-a retrospective clinical evaluation.. Vet Anaest Analg (2008) 35:38–44.
  44. Benmasour P, Husulak ML, Bracamonte JL, Beazley SG, Withnall E, Duke-Novakovski T. Cardiopulmonary effects of an infusion of remifentanil or morphine in horses anesthetized with isoflurane and dexmedetomidine.. Vet Anaest Analg (2014) 41:46–56.
    doi: 10.1111/vaa.12149pubmed: 24673858google scholar: lookup
  45. Marntell S, Nyman G, Funkquist P, Hedenstierna G. Effects of acepromazine on pulmonary gas exchange and circulation during sedation and dissociative anaesthesia in horses.. Vet Anaest Analg (2005) 32:83–93.
  46. Patel PM, Drummond JC, Lemkuil BP. Cerebral physiology and the effects of anesthetic drugs.. In: Cohen NH, Eriksson LI, Fleisher LA, et al. editors. Miller's Anesthesia. Elsevier Saunders; (2015). p. 387–422..
  47. Hopkins RO, Bigler ED. Pulmonary disorders.. In: Tarter RE, Butters M, Beers SR. editors. Medical Neuropsychology. Alphen aan den Rijn: Kluwer Academic; (2001). p. 25–50..
  48. Auckburally A, Nyman G. Review of hypoxaemia in anaesthetized horses: predisposing factors, consequences and management.. Vet Anaesth Analg (2017) 44:397–408.
    doi: 10.1016/j.vaa.2016.06.001pubmed: 28385614google scholar: lookup
  49. Romer LM, Dempsey JA, Lovering A, Eldridge M. Exercise-induced arterial hypoxemia: consequences for locomotor muscle fatigue.. Adv Exp Med Biol (2006) 588:47–55.
    doi: 10.1007/978-0-387-34817-9_5pubmed: 17089878google scholar: lookup
  50. Kushiro T, Yamashita K, Umar MA, Maehara S, Wakaiki S, Abe R. Anesthetic and cardiovascular effects of balanced anesthesia using constant rate infusion of midazolam-ketamine-medetomidine-with inhalation of oxygen-sevoflurane (MKM-OS) in horses.. J Vet Med Sci (2005) 67:379–84.
    doi: 10.1292/jvms.67.379pubmed: 15876787google scholar: lookup
  51. Flaherty D, Nolan A, Reid J, Monteiro AM. The pharmacokinetics of ketamine after a continuous infusion under halothane anaesthesia in horses.. J Vet Anaesth (1998) 25:31–6.
  52. Spadavecchia C, Stucki F, Moens Y, Schatzmann U. Anaesthesia in horses using halothane and intravenous ketamine-guaiphenesin: a clinical study.. Vet Anaesth Analg (2002) 29:20–8.
  53. Kruger K, Stegmann GF. Partial intravenous anaesthesia in 5 horses using ketamine, lidocaine, medetomidine and halothane.. J S Afr Vet Assoc (2009) 80:233–6.
    doi: 10.4102/jsava.v80i4.214pubmed: 20458864google scholar: lookup
  54. Kaul SU, Beard DJ, Millar MD. Preganglionic sympathetic activity and baroreceptor responses during hypothermia.. Br J Anaesth (1973) 45:433–9.
    doi: 10.1093/bja/45.5.433pubmed: 4351831google scholar: lookup
  55. Maaravi Y, Weiss T. The effect of prolonged hypothermia on cardiac function in a young patient with accidental hypothermia.. Chest (1990) 98:1019–20.
    doi: 10.1378/chest.98.4.1019pubmed: 2209109google scholar: lookup
  56. Niwa K, Takizawa S, Takagi S, Shinohara Y. Mild hypothermia disturbs cerebrovascular autoregulation in awake rats.. Brain Res (1998) 789:68–73.
    doi: 10.1016/S0006-8993(98)00013-4pubmed: 9602065google scholar: lookup