Prostaglandin E2 hastens oviductal transport of equine embryos.
Abstract: The hypothesis that treatment of pregnant mares with prostaglandin E2 (PGE2) hastens the oviductal transport of equine embryos was tested by treating bred mares with PGE2 on Day 3 after ovulation and subsequently measuring the rate of hastened oviductal transport (estimated by the uterine embryo recovery rate on Day 4 after ovulation). In a preliminary, noncontrolled experiment, oviductal transport was apparently not hastened after intramuscular, intrauterine, or intraperitoneal PGE2 administration to bred mares (0/6, 0/3, and 0/3 mares, respectively). Oviductal transport appeared to be hastened in 1/13 mares after a single intraoviductal administration of PGE2, and in 2/2 mares after continuous intraoviductal administration of PGE2. In a subsequent, controlled experiment, treatment with a continuous intraoviductal infusion of PGE2 hastened oviductal transport in significantly more (p less than 0.01) mares versus a continuous intraoviductal infusion of vehicle or no treatment (6/11 vs. 0/11 or 0/11 mares, respectively). Unfertilized oocytes and oviductal masses were also recovered from mare uteri after continuous intraoviductal PGE2 administration, but were not recovered after vehicle administration or no treatment. These results support the hypothesis that PGE2 treatment hastens the oviductal transport of equine embryos, and suggest a role for embryonic PGE2 in the initiation of selective oviductal transport in the mare.
Publication Date: 1991-10-01 PubMed ID: 1751628DOI: 10.1095/biolreprod45.4.544Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This study explores the impact of prostaglandin E2 (PGE2) on the transport rate of embryos in mares’ oviducts, suggesting that PGE2 significantly hastens this process.
Objective of the Study
- The aim of this research was to explore the effect of prostaglandin E2 (PGE2 — a hormone-like substance present in various tissues) on the speed of oviductal (the tubes leading from the ovaries to the uterus) transport of equine embryos.
- The researchers proposed an hypothesis that administering PGE2 to pregnant mares would expedite this process.
Methodology
- The hypothesis was tested by administering PGE2 to mares three days post-ovulation and subsequently measuring the hastened rate of embryo transport through the oviducts.
- This study was carried out on two fronts: a preliminary non-controlled experiment, and a subsequent controlled experiment.
- In the initial experiment set, mares were intramuscularly, intrauterinely, or intraperitoneally administered with PGE2, but there seemed to be no improvement of embryo transport speed. Some improvement was seen when PGE2 was administered into the oviduct itself, hinting at a potential method of effective application.
- In the controlled experiment, mares were continuously given an intraoviductal infusion of PGE2, which lead to a notable improvement in the number of cases with expedited oviductal transport.
Results and Conclusion
- The results showed that continuous intraoviductal administration of PGE2 accelerated oviductal transport in significantly more mares compared to those given a vehicle infusion, or no treatment at all.
- Unfertilized oocytes and oviductal masses were also found in mare uteri following the sustained intraoviductal PGE2 application, but they were not discovered in mares given no treatment or a vehicle infusion only.
- The researchers concluded that their results support the hypothesis that PGE2 hastens the transport of embryos in the oviduct, and suggested that the embryonic PGE2 could play a part in initiating selective oviductal transport in mares.
Cite This Article
APA
Weber JA, Freeman DA, Vanderwall DK, Woods GL.
(1991).
Prostaglandin E2 hastens oviductal transport of equine embryos.
Biol Reprod, 45(4), 544-546.
https://doi.org/10.1095/biolreprod45.4.544 Publication
Researcher Affiliations
- Department of Animal and Veterinary Science, University of Idaho, Moscow 83843.
MeSH Terms
- Animals
- Dinoprostone / pharmacology
- Drug Administration Routes
- Embryo, Mammalian / physiology
- Female
- Horses / physiology
- Oviducts / drug effects
- Oviducts / physiology
- Pregnancy
Citations
This article has been cited 13 times.- Vegas AR, Podico G, Canisso IF, Bollwein H, Fröhlich T, Bauersachs S, Almiñana C. Dynamic regulation of the transcriptome and proteome of the equine embryo during maternal recognition of pregnancy.. FASEB Bioadv 2022 Dec;4(12):775-797.
- Segabinazzi LGTM, Roberts BN, Peterson EW, Ambrosia R, Bergfelt D, Samper J, French H, Gilbert RO. Early Pregnancy in Jennies in the Caribbean: Corpus Luteum Development and Progesterone Production, Uterine and Embryo Dynamics, Conceptus Growth and Maturation.. Animals (Basel) 2022 Jan 6;12(2).
- Benammar A, Derisoud E, Vialard F, Palmer E, Ayoubi JM, Poulain M, Chavatte-Palmer P. The Mare: A Pertinent Model for Human Assisted Reproductive Technologies?. Animals (Basel) 2021 Aug 4;11(8).
- McGlade EA, Herrera GG, Stephens KK, Olsen SLW, Winuthayanon S, Guner J, Hewitt SC, Korach KS, DeMayo FJ, Lydon JP, Monsivais D, Winuthayanon W. Cell-type specific analysis of physiological action of estrogen in mouse oviducts.. FASEB J 2021 May;35(5):e21563.
- Anamthathmakula P, Winuthayanon W. Prostaglandin-Endoperoxide Synthase 2 (PTGS2) in the Oviduct: Roles in Fertilization and Early Embryo Development.. Endocrinology 2021 Apr 1;162(4).
- Hasan MM, Viil J, Lättekivi F, Ord J, Reshi QUA, Jääger K, Velthut-Meikas A, Andronowska A, Jaakma Ü, Salumets A, Fazeli A. Bovine Follicular Fluid and Extracellular Vesicles Derived from Follicular Fluid Alter the Bovine Oviductal Epithelial Cells Transcriptome.. Int J Mol Sci 2020 Jul 28;21(15).
- Bridi A, Perecin F, Silveira JCD. Extracellular Vesicles Mediated Early Embryo-Maternal Interactions.. Int J Mol Sci 2020 Feb 10;21(3).
- Saint-Dizier M, Schoen J, Chen S, Banliat C, Mermillod P. Composing the Early Embryonic Microenvironment: Physiology and Regulation of Oviductal Secretions.. Int J Mol Sci 2019 Dec 28;21(1).
- Pfeiffer CA, Meyer AE, Brooks KE, Chen PR, Milano-Foster J, Spate LD, Benne JA, Cecil RF, Samuel MS, Ciernia LA, Spinka CM, Smith MF, Wells KD, Spencer TE, Prather RS, Geisert RD. Ablation of conceptus PTGS2 expression does not alter early conceptus development and establishment of pregnancy in the pig†.. Biol Reprod 2020 Feb 14;102(2):475-488.
- Ross KA, Kolb DS, Macedo A, Anderson M, Klein C. Seminal plasma does not aid in the transport of phenolsulfonphthalein across the uterotubal junction in mares.. Can Vet J 2018 Sep;59(9):988-992.
- Aurich C, Budik S. Early pregnancy in the horse revisited - does exception prove the rule?. J Anim Sci Biotechnol 2015;6:50.
- Maillo V, Gaora PÓ, Forde N, Besenfelder U, Havlicek V, Burns GW, Spencer TE, Gutierrez-Adan A, Lonergan P, Rizos D. Oviduct-Embryo Interactions in Cattle: Two-Way Traffic or a One-Way Street?. Biol Reprod 2015 Jun;92(6):144.
- Bazer FW, Song G, Thatcher WW. Roles of conceptus secretory proteins in establishment and maintenance of pregnancy in ruminants.. Asian-Australas J Anim Sci 2012 Jan;25(1):1-16.
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