Quantitation of the immunoglobulins in reproductive tract secretions of the mare.

The research focuses on measuring the levels of immunoglobulins IgG, IgA, IgM and the protein albumin in different secretions within the reproductive tract of horses. The results indicate that these levels vary depending on the type of secretion and the horse’s health, with notable differences observed in mares with a history of chronic inflammation in the uterus (chronic metritis).

The Study on Immunoglobulins in Reproductive Tract Secretions

• The researchers measured the concentrations of immunoglobulins IgG, IgA, IgM and the protein albumin in different areas of the horse’s reproductive tract. Immunoglobulins are proteins produced by the immune system to combat potential threats like bacteria and viruses.

Results of the Study

• In the follicular fluid, the concentration of proteins was dependent on their concentration in the serum and their molecular size.
• Only IgG was detectable in secretions from the oviduct, but the ratio of IgG to albumin was not significantly different from that in the serum. Albumin is a protein that has various important functions in the body, including maintaining the balance of fluids and carrying substances through the blood.
• In uterine secretions, IgG was the predominant immunoglobulin, followed by IgA and IgM. However, transudation of serum into these secretions was minimal.
• In the intestinal secretions, the levels of IgA were slightly higher than IgG, with albumin and IgM present at low levels.

Findings in Mares with Chronic Metritis

• Notably, the researchers observed elevated levels of IgG, IgA and albumin in the uterine secretions of mares with a history of chronic metritis, a condition characterized by long-term inflammation of the uterus.
• This finding suggests that such conditions can significantly alter the distribution of these immune proteins in horses’ reproductive tracts, potentially influencing their immune responses and their fertility.