Quantitative comparisons of acidic prealbumin (PR) phenotypes in horses.
Abstract: Comparisons of Pr protein amounts in horse sera have been performed using .’s (1965) immunodiffusion technique. Relative values against a chosen standard of 100 % were determined for a total of 435 horses. There was considerable variation between horses, the highest Pr value being 125 and the lowest 50 % of the standard. In animals of the same Pr phenotype the mean Pr values were significantly higher (P < 0.001) in foals than in mares. In Norwegian Trotter horses the Pr value of Pr NN animals was significantly higher than that of Pr SS phenotypes, whereas the mean Pr values of Pr SS was significantly higher than that of Pr UU Warmblood Trotter horses, the Pr value of Pr SS being 90 and the Pr-UU 80 % of that of Pr NN. No difference between sexes with regard to Pr values was found. Ved bruk av (1965) immundiffusjons-teknikk er det foretatt sammenligninger av konsentrasjoner av Pr-protein i hestesera. Relative verdier i forhold til en valgt standard på 100 % blebestemt for i alt 435 hester. Det var stor variasjon mellom nestene. Den høyeste Pr-verdi var 125 og den laveste 50 % av standarden. Hos dyr med den samme Pr-fenotype var middelverdiene signifikant høyere hos føll enn hos hopper. Hos norske traverhester var Pr-verdiene signifikant høyere hos NN-dyr enn hos dyr med Pr-fenotype SS, mens middelverdiene hos SS-dyr var signifikant høyere enn hos varmblods-traverhester med Pr-fenotype UU. Pr-verdiene for Pr-SS var 90 % og for Pr-UU 80 av tilsvarende verdi for Pr-NN. Det ble ikke funnet noen forskjell på Pr-verdiene mellom kjønnene.
Publication Date: 1980-01-01 PubMed ID: 7446321PubMed Central: PMC8317704DOI: 10.1186/BF03546870Google Scholar: Lookup
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- Comparative Study
- Journal Article
Summary
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The study examines the variation in the amounts of prealbumin protein in horses using an immunodiffusion technique, comparing different groups of horses including foals, mares, and different breeds.
Research Methodology
- The research involves a quantitative comparison of prealbumin (Pr) proteins in the serum of horses. This comparison was carried out using an immunodiffusion technique, which is a method used for the detection and quantification of antibodies and antigens in a fluid sample (in this case, the horse’s serum).
- In total, 435 horses were tested in this study. These horses belonged to different categories in terms of age and breed, which allowed the researchers to make comparisons about the amounts of Pr protein across these groups.
Research Findings
- The results showed a noticeable variation in the Pr protein value from horse to horse. The values ranged from 50% to 125% of a chosen standard value.
- When comparing horses of the same Pr phenotype (genetic makeup), it was found that foals (young horses) typically had higher mean Pr values than mares (adult female horses), with this difference being statistically significant.
- The study also revealed significant differences among horse breeds. In Norwegian Trotter horses, for example, those with Pr NN phenotype had significantly higher Pr values compared to those with Pr SS phenotype. Interestingly, this Pr SS group had higher mean Pr values than Warmblood Trotter horses with a Pr UU phenotype.
- No difference in Pr protein values was found between male and female horses, suggesting that the sex of a horse does not influence Pr levels.
Conclusion
- This research enhances our understanding of the Pr protein concentration in horses’ serum and the factors that may influence it. Such information is essential in veterinary medicine and equine health management.
- The significant variation in Pr values between different horse breeds and among different age groups indicates that factors such as breed and age may influence Pr protein levels. This further emphasizes the need for personalized health care approaches in veterinary medicine based on an individual animal’s specific genetic and physiological traits.
Cite This Article
APA
Ek N, Braend M.
(1980).
Quantitative comparisons of acidic prealbumin (PR) phenotypes in horses.
Acta Vet Scand, 21(3), 380-388.
https://doi.org/10.1186/BF03546870 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Female
- Horses / genetics
- Male
- Phenotype
- Prealbumin / genetics
- Serum Albumin / genetics
- Sex Factors
References
This article includes 9 references
- Braend M. Genetics of horse acidic prealbumins.. Genetics 1970 Jul;65(3):495-503.
- Ek N. The characterization of equine prealbumin (Pr) proteins by antigen-antibody crossed electrophoresis.. Acta Vet Scand 1979;20(2):180-90.
- Ek N. Quantitation of the Pr protein in equine serum in diseases. In preparation. 1980.
- Fagerhol MK. Quantitative studies on the inherited variants of serum alpha-1-antitrypsin.. Scand J Clin Lab Invest 1969 Feb;23(1):97-103.
- Ganrot PO, Laurell CB, Eriksson S. Obstructive lung disease and trypsin inhibitors in alpha-1-antitrypsin deficiency.. Scand J Clin Lab Invest 1967;19(3):205-8.
- Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion.. Immunochemistry 1965 Sep;2(3):235-54.
- Matthews AG. Identification and characterisation of the major antiproteases in equine serum and an investigation of their role in the onset of chronic obstructive pulmonary disease (COPD).. Equine Vet J 1979 Jul;11(3):177-82.
- Matthews AG. The nature of the prealbumin 'esterases' of horse serum.. Anim Blood Groups Biochem Genet 1979;10(3):181-4.
- Scott M. Prealbumins in the Arab Horse; a model for a better interpretation of the system. XVI Int. Conf. Anim. Blood Groups Biochem. Polym. 158 (Abstr.) USSR, Leningrad, August 14–18, 1978.
Citations
This article has been cited 3 times.- Ek N. Antigen-antibody crossed electrophoretic studies and quantitative comparisons of serum transferrin types in horses. Acta Vet Scand 1981;22(2):246-59.
- Ek N. Concentration of serum prealbumin (PR) protein in sick horses and its correlation to blood leucocyte count and albumin content in serum. Acta Vet Scand 1980;21(4):482-97.
- Patterson SD, Bell K, Shaw DC. The equine major plasma serpin multigene family: partial characterization including sequence of the reactive-site regions. Biochem Genet 1991 Oct;29(9-10):477-99.
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