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The Onderstepoort journal of veterinary research2024; 91(1); e1-e10; doi: 10.4102/ojvr.v91i1.2181

Rabies in equids in Sudan.

Abstract: Rabies is endemic in Sudan with continuing outbreaks occurring annually, the most common animals affected are dogs, followed by goats and equids. This work focused on equid rabies, to elucidate the current situation of the disease through analysis of reports of equid rabies outbreaks in Sudan during 2010-2022 supported by laboratory confirmation of the disease. During the study period, 66 animals were affected during 35 equid rabies outbreaks. The highest incidences were found in Al Gezira (30.3%), followed by Darfur (24.2%) and Kordofan (15.2%). The highest incidence rate was observed during 2018 (33.3%), followed by 2015 (16.7%). Within seasons, the highest incidence rate was reported during October - December (33.3%), followed by July - September (30.3%). Chi-square analysis revealed a significant correlation between rabid animals and year, season, and state. Wald statistics demonstrated that year and season had a significant association with the disease. Virus antigen was identified (72.2%) in brain tissues using the fluorescent antibody test. Viral nucleic acid was amplified (n = 6) with a reverse transcriptase polymerase chain reaction assay.Contribution: As equids are kept in close contact with humans and other animals in the country, according to the present investigation, equid rabies in Sudan is a potential public health concern, emphasising the importance of implementing effective control measures.
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Publication Date: 2024-09-26 PubMed ID: 39354785PubMed Central: PMC11447646DOI: 10.4102/ojvr.v91i1.2181Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article presents a comprehensive study on the prevalence of Rabies in equids (like horses, donkeys, and mules) in Sudan between the years 2010-2022. The results highlight that Rabies in equids, given their close contact with humans, poses a significant public health concern that warrants effective control measures.

Overall Study Details

  • The study centers around the prevalence of Rabies, a disease endemic to Sudan, specifically in equids. The research period spans from 2010-2022.
  • The study involved analyzing reports of Rabies outbreaks in Sudan’s equid population alongside laboratory confirmation of the disease.
  • 66 animals were affected during 35 equid Rabies outbreaks in the designated study period.

Incidences and Location

  • The highest incidence of the disease was found in Al Gezira (30.3%), followed by Darfur (24.2%) and Kordofan (15.2%).
  • The year with the highest incidence rate was 2018, accounting for 33.3% of the cases of the disease, followed by 2015 (16.7%).
  • The most common season for the disease was between October and December (33.3%), followed closely by July – September (30.3%).
  • A significant correlation was established between rabid animals, the year, season, and the state, using Chi-square analysis. Wald statistics further affirmed this correlation, showing a significant association between the season and the year with the disease.

Lab Confirmation and Public Health Concern

  • Virus antigen identified in 72.2% of the brain tissues examined using the fluorescent antibody test.
  • Viral nucleic acid was also amplified in six instances using a reverse transcriptase polymerase chain reaction assay.
  • The research concludes that given the close contact equids have with humans and other animals in Sudan, rabies in equids presents a significant public health concern. The article emphasizes the importance of deploying efficient control measures to contain the disease.

Cite This Article

APA
Ali YH, Mohieddeen TAG, Abdellatif MM, Ahmed BM, Saeed IK, Attaalfadeel HM, Ali AA. (2024). Rabies in equids in Sudan. Onderstepoort J Vet Res, 91(1), e1-e10. https://doi.org/10.4102/ojvr.v91i1.2181

Publication

The Onderstepoort journal of veterinary research
ISSN: 2219-0635
NlmUniqueID: 0401107
Country: South Africa
Language: English
Volume: 91
Issue: 1
Pages: e1-e10

Researcher Affiliations

Ali, Yahia H
  • Department of Biology, College of Science and Arts, Rafha, Northern Border University, Arar, Saudi Arabia; and Virology Department, Central Veterinary Research Laboratory, Khartoum. y1beik@gmail.com.
Mohieddeen, Tenzeil A G
    Abdellatif, Muaz M
      Ahmed, Baraa Mohammed
        Saeed, Intisar K
          Attaalfadeel, Husham M
            Ali, Amani A

              MeSH Terms

              • Animals
              • Sudan / epidemiology
              • Rabies / epidemiology
              • Rabies / veterinary
              • Horse Diseases / epidemiology
              • Horse Diseases / virology
              • Equidae
              • Disease Outbreaks / veterinary
              • Incidence
              • Horses
              • Seasons

              Conflict of Interest Statement

              The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.

              References

              This article includes 69 references
              1. Al-Shamahy HA, Sunhope A, Al-Moyed KA. Prevalence of rabies in various species in Yemen and risk factors contributing to the spread of the disease. Sultan Qaboos University Medical Journal 13, 404.
                doi: 10.12816/0003263pmc: PMC3749025pubmed: 23984026google scholar: lookup
              2. Alaifan T, Altamimi A. A systematic review of epidemiology of rabies in Arab countries. Journal of Health Informatics in Developing Countries 13(2), 1–15.
              3. Alhassan S, Garba B, Bello B, Musa S, Ali M, Tanko Y. A case of fatal rabies in a donkey in Dawakin Tofa, Kano State, Nigeria. Journal of Animal Health and Production 8, 40–44.
              4. Ali Y. Outbreak of rabies in South Darfur, Sudan. The Veterinary Record 150, 610–612.
                doi: 10.1136/vr.150.19.610pubmed: 12036246google scholar: lookup
              5. Ali Y, Intisar K, Wegdan H, Ali E. Epidemiology of rabies in Sudan. Journal of Animal and Veterinary Advances 5, 266–270.
              6. Ali YH, Hameid OA, Ibrahim AE. Epidemiological studies of rabies in Khartoum – State –Sudan. Sudan Medical Journal 39(4), 22–26.
              7. Ali YH, Intisar KS. Epidemiology of rabies in Sudan (2003–2007). Sudan Journal of Veterinary Science and Animal Husbandry 48, 104–111.
              8. Altantogtokh D, Boldbaatar B, Matulis G, Lilak AA, Tsogbadrakh N, Chimedtseren B. Rabies exposure from infected horse bite in an urban setting: A case study from Mongolia. Zoonotic Diseases 4, 1–7.
                doi: 10.3390/zoonoticdis4010001google scholar: lookup
              9. Andrade EA, Monteiro F, Solorio MR, Raia VA, Xavier DA, Colino E. Livestock rabies in Pará state, Brazil: A descriptive study (2004 to 2013). Pesquisa Veterinária Brasileira 40, 234–241.
                doi: 10.1590/1678-5150-pvb-6307google scholar: lookup
              10. Anon. A perspective on rabies in the Middle East-beyond neglect. Veterinary Sciences 5(3), 67.
                doi: 10.3390/vetsci5030067pmc: PMC6165288pubmed: 30018199google scholar: lookup
              11. Bannazadeh Baghi H, Alinezhad F, Kuzmin I, Rupprecht CE. A perspective on rabies in the Middle East – Beyond neglect. Veterinary Sciences 5, 67.
                doi: 10.3390/vetsci5030067pmc: PMC6165288pubmed: 30018199google scholar: lookup
              12. Banyard AC, Horton DL, Freuling C, Müller T, Fooks AR. Control and prevention of canine rabies: The need for building laboratory-based surveillance capacity. Antiviral Research 98, 357–364.
                doi: 10.1016/j.antiviral.2013.04.004pubmed: 23603498google scholar: lookup
              13. Baraa AM, Ali YH, Balal AG, ElMagboul S. Assessment of rabies situation in Sudan during 2007–2010. Sudan Journal of Veterinary Sciences and Animal Husbandry 51, 19–31.
              14. Barrandeguy ME, Carossino M. Infectious diseases in donkeys and mules: An overview and update. Journal of Equine Veterinary Science 65, 98–105.
                doi: 10.1016/j.jevs.2018.02.026google scholar: lookup
              15. Benchohra M. Veterinary and medical management of an animal rabies outbreak in West Algeria: Infringements to the current legislation. World Journal of Medical Sciences 13, 176–178.
              16. Bitek AO, Osoro E, Munyua PM, Nanyingi M, Muthiani Y, Kiambi S. A hundred years of rabies in Kenya and the strategy for eliminating dog-mediated rabies by 2030. AAS Open Research 1, 23.
                doi: 10.12688/aasopenres.12872.1pmc: PMC7117960pubmed: 32259023google scholar: lookup
              17. Brookes VJ, Gill G, Singh C, Sandhu B, Dhand N, Singh B. Exploring animal rabies endemicity to inform control programmes in Punjab, India. Zoonoses and Public Health 65, e54–e65.
                doi: 10.1111/zph.12409pubmed: 28990371google scholar: lookup
              18. Carrieri ML, Peixoto ZMP, Paciencia MLB, Kotait I, Germano PML. Laboratory diagnosis of equine rabies and its implications for human postexposure prophylaxis. Journal of Virological Methods 138, 1–9.
                doi: 10.1016/j.jviromet.2006.07.005pubmed: 16919789google scholar: lookup
              19. Coelho CSS, Sodré TDERP, Freitas MD, Moroz LR, Nunes TL, Da Cunha Peixoto T. Rabies in a previously vaccinated horse: Case report. Acta Veterinaria Brasilica 16(2), 84–89.
                doi: 10.21708/avb.2022.16.2.10310google scholar: lookup
              20. Dean D, Abelseth M. The fluorescent antibody test In Laboratory techniques in rabies. in Kaplan MM & Koprowski H (eds.), Laboratory techniques in rabies, 3rd edn., p. 73, World Health Organisation, Geneva.
                pubmed: 4219510
              21. Digafe RT, Kifelew LG, Mechesso AF. Knowledge, attitudes and practices towards rabies: Questionnaire survey in rural household heads of Gondar Zuria District, Ethiopia. BMC Research Notes 8, 1–7.
                doi: 10.1186/s13104-015-1357-8pmc: PMC4566865pubmed: 26328612google scholar: lookup
              22. Douangngeun B, Theppangna W, Phommachanh P, Chomdara K, Phiphakhavong S, Khounsy S. Rabies surveillance in dogs in Lao PDR from 2010–2016. PLoS Neglected Tropical Diseases 11, e0005609.
                doi: 10.1371/journal.pntd.0005609pmc: PMC5469496pubmed: 28570561google scholar: lookup
              23. El Harrak. Epidemiological factors and control of rabies in North Africa. Presentation given at the OIE Global Conference on Rabies Control, Incheon, Republic of Korea, September 7–9, 2011.
              24. El Nasri M. A review of animal rabies in the Sudan. Sudan Journal of Veterinary Science and Animal Husbandry 3, 20–24.
              25. Faizee N, Hailat N, Ababneh M, Hananeh W, Muhaidat A. Pathological, immunological and molecular diagnosis of rabies in clinically suspected animals of different species using four detection techniques in Jordan. Transboundary and Emerging Diseases 59, 154–164.
                doi: 10.1111/j.1865-1682.2011.01255.xpubmed: 22390575google scholar: lookup
              26. Feng Y, Ma J, Sun S, Chi L, Kou Z, Tu C. Epidemiology of animal rabies – China, 2010–2020. China CDC Weekly 3, 815.
                doi: 10.46234/ccdcw2021.202pmc: PMC8477053pubmed: 34594998google scholar: lookup
              27. Feng Y, Shi Y, Yu M, Xu W, Gong W, Tu Z. Livestock rabies outbreaks in Shanxi province, China. Archives of Virology 161, 2851–2854.
                doi: 10.1007/s00705-016-2982-9pubmed: 27422397google scholar: lookup
              28. Fisher CR, Streicker DG, Schnell MJ. The spread and evolution of rabies virus: Conquering new frontiers. Nature Reviews Microbiology 16, 241–255.
                doi: 10.1038/nrmicro.2018.11pmc: PMC6899062pubmed: 29479072google scholar: lookup
              29. Gautret P, Ribadeau-Dumas F, Parola P, Brouqui P, Bourhy H. Risk for rabies importation from North Africa. Emerging Infectious Diseases 17, 2187.
                doi: 10.3201/eid1712.110300pmc: PMC3311213pubmed: 22185767google scholar: lookup
              30. Getachew A, Burden F, Wernery U. Common infectious diseases of working donkeys: Their epidemiological and zoonotic role. Journal of Equine Veterinary Science 39, S107.
              31. Gizachew A, Endebu B, Pal M, Abdo J, Deressa A. Spontaneously occurring fatal rabies in a donkey. International Journal of Livestock Research 2, 109–111.
                doi: 10.1016/j.jevs.2016.02.225google scholar: lookup
              32. Hameid O. Rabies situation in Khartoum province, Sudan 1977–1987. Sudan Journal of Veterinary Science and Animal Husbandry 28, 83–88.
                doi: 10.1136/vr.128.3.61google scholar: lookup
              33. Hameid O. Rabies in Sudan: An epidemiological review. Veterinary Record 128, 61–62.
                pubmed: 2003355
              34. Hampson K, Dushoff J, Bingham J, Brückner G, Ali Y, Dobson A. Synchronous cycles of domestic dog rabies in sub-Saharan Africa and the impact of control efforts. Proceedings of the National Academy of Sciences 104, 7717–7722.
                doi: 10.1073/pnas.0609122104pmc: PMC1863501pubmed: 17452645google scholar: lookup
              35. Harbi M. The incidence of rabies in animals in the Sudan. Bulletin of Animal Health and Production in Africa 24, 43–46.
                pubmed: 1052879
              36. Hassine TB, Ali MB, Ghodhbane I, Said ZB, Hammami S. Rabies in Tunisia: A spatio-temporal analysis in the region of CapBon-Nabeul. Acta Tropica 216, 105822.
                doi: 10.1016/j.actatropica.2021.105822pubmed: 33421422google scholar: lookup
              37. Heaton PR, Johnstone P, Mcelhinney LM, Cowley R, O’Sullivan E, Whitby JE. Heminested PCR assay for detection of six genotypes of rabies and rabies-related viruses. Journal of Clinical Microbiology 35, 2762–2766.
                doi: 10.1128/jcm.35.11.2762-2766.1997pmc: PMC230057pubmed: 9350729google scholar: lookup
              38. Kainga H, Chatanga E, Phonera MC, Kothowa JP, Dzimbiri P, Kamwendo G. Current status and molecular epidemiology of rabies virus from different hosts and regions in Malawi. Archives of Virology 168, 61.
                doi: 10.1007/s00705-022-05635-zpmc: PMC9834359pubmed: 36631547google scholar: lookup
              39. Kalthoum S, Guesmi K, Gharbi R, Baccar MN, Seghaier C, Zrelli M. Temporal and spatial distributions of animal and human rabies cases during 2012 and 2018, in Tunisia. Veterinary Medicine and Science 7, 686–696.
                doi: 10.1002/vms3.438pmc: PMC8136934pubmed: 33570258google scholar: lookup
              40. Khalafalla AI, Ali YH. Rabies virus infection. in Tkachev S. (ed.), Livestock in rabies virus at the beginning of 21st Century, IntechOpen.
                doi: 10.5772/intechopen.98228google scholar: lookup
              41. Khayli M, Lhor Y, Derkaoui S, Lezaar Y, Harrak M, Sikly L. Determinants of canine rabies in Morocco: How to make pertinent deductions for control. Epidemiology Open Journal 4, 1–11.
                doi: 10.17140/EPOJ-4-113google scholar: lookup
              42. Kleinbaum DG, Klein M, Pryor ER. Logistic regression: A self-learning text. Springer, New York, NY.
              43. Koeppel KN, Van Schalkwyk OL, Thompson PN. Patterns of rabies cases in South Africa between 1993 and 2019, including the role of wildlife. Transboundary and Emerging Diseases 69, 836–848.
                doi: 10.1111/tbed.14080pubmed: 33738979google scholar: lookup
              44. Krebs JW, Mondul AM, Rupprecht CE, Childs JE. Rabies surveillance in the United States during 2000. Journal of the American Veterinary Medical Association 219, 1687–1699.
                doi: 10.2460/javma.2001.219.1687pubmed: 11767918google scholar: lookup
              45. Kumar B, Manuja A, Gulati B, Virmani N, Tripathi B. Suppl-2, M5: Zoonotic viral diseases of equines and their impact on human and animal health. The Open Virology Journal 12, 80.
                doi: 10.2174/1874357901812010080pmc: PMC6142672pubmed: 30288197google scholar: lookup
              46. Ma X, Bonaparte S, Corbett P, Orciari LA, Gigante CM, Kirby JD. Rabies surveillance in the United States during 2021. Journal of the American Veterinary Medical Association 261, 1045–1053.
                doi: 10.2460/javma.23.02.0081pubmed: 36884381google scholar: lookup
              47. Malaga H, Nieto EL, Gambirazio C. Canine rabies seasonality. International Journal of Epidemiology 8, 243–246.
                doi: 10.1093/ije/8.3.243pubmed: 575355google scholar: lookup
              48. Minoungou G, Dahourou L, Savadogo M, Tialla D, Comabari A, Kanyala E. Surveillance of animal rabies in Burkina Faso: A retrospective laboratory data from 2008 to 2012. International Journal of Veterinary Science 10, 172–176.
                doi: 10.47278/journal.ijvs/2021.051google scholar: lookup
              49. Monje F, Kadobera D, Ndumu DB, Bulage L, Ario AR. Trends and spatial distribution of animal bites and vaccination status among victims and the animal population, Uganda: A veterinary surveillance system analysis, 2013–2017. PLoS Neglected Tropical Diseases 15, e0007944.
                doi: 10.1371/journal.pntd.0007944pmc: PMC8084341pubmed: 33872314google scholar: lookup
              50. Numan M, Qureshi ZA, Shauket M, Hashmi HA, Iqbal M, Gill ZJ. Rabies out-break in mules at Mansehra, Pakistan. Research in Veterinary Science 90, 160–162.
                doi: 10.1016/j.rvsc.2010.04.020pubmed: 20483443google scholar: lookup
              51. Nyasulu PS, Weyer J, Tschopp R, Mihret A, Aseffa A, Nuvor SV. Rabies mortality and morbidity associated with animal bites in Africa: A case for integrated rabies disease surveillance, prevention and control: A scoping review. BMJ Open 11, e048551.
                doi: 10.1136/bmjopen-2020-048551pmc: PMC8640643pubmed: 34857556google scholar: lookup
              52. Oliveira FAS, Castro RJS, De Oliveira JF, Barreto FM, Farias MPO, Marinho GLDOC. Geographical and temporal spread of equine rabies in Brazil. Acta Tropica 227, 106302.
                doi: 10.1016/j.actatropica.2022.106302pubmed: 34990596google scholar: lookup
              53. Ortega-Sánchez R, Bárcenas-Reyes I, Cantó-Alarcón GJ, Luna-Cozar J, Rojas-Anaya E, Contreras-Magallanes YG. Descriptive and time-series analysis of rabies in different animal species in Mexico. Frontiers in Veterinary Science 9, 800735.
                doi: 10.3389/fvets.2022.800735pmc: PMC9010467pubmed: 35433923google scholar: lookup
              54. Pantha S, Subedi D, Poudel U, Subedi S, Kaphle K, Dhakal S. Review of rabies in Nepal. One Health 10, 100155.
                doi: 10.1016/j.onehlt.2020.100155pmc: PMC7582201pubmed: 33117872google scholar: lookup
              55. Pimentel MFA, Nassarden SM, Cândido SL, Dutra V, Nakazato L. Genotyping of rabies positive samples isolated from animals in Mato Grosso and Rondônia–Brazil. Infection, Genetics and Evolution 103, 105336.
                doi: 10.1016/j.meegid.2022.105336pubmed: 35817398google scholar: lookup
              56. Rahman MT, Sobur MA, Islam MS, Ievy S, Hossain MJ, El Zowalaty ME. Zoonotic diseases: Etiology, impact, and control. Microorganisms 8, 1405.
                doi: 10.3390/microorganisms8091405pmc: PMC7563794pubmed: 32932606google scholar: lookup
              57. Rees EE, Pond BA, Tinline RR, Bélanger D. Understanding effects of barriers on the spread and control of rabies. Advances in Virus Research 79, 421–447.
                doi: 10.1016/B978-0-12-387040-7.00020-2pubmed: 21601058google scholar: lookup
              58. Ribeiro J, Vieira RGV, Martins CM, Ferreira F, Araujo JP, Ullmann LS. Spatial distribution of bat shelters and livestock rabies in Southern Brazil. Vector-Borne and Zoonotic Diseases 21, 785–795.
                doi: 10.1089/vbz.2020.2730pubmed: 34661486google scholar: lookup
              59. Ripani A, Mérot J, Bouguedour R, Zrelli M. Review of rabies situation and control in the North African region with a focus on Tunisia. Revue Scientifique et Technique/Office International des Epizooties 36, 831–838.
                doi: 10.20506/rst.36.3.2718pubmed: 30160705google scholar: lookup
              60. Saad S, Adam A, Abdelateef AH. Binary logistic regression to estimate household income efficiency (South Darfur rural areas-Sudan). International Journal of Advanced Statistics and Probability 4, 31–35.
                doi: 10.14419/ijasp.v4i1.5657google scholar: lookup
              61. Schwarz DGG, Barreto FM, Branco M, Marinho GDO, Farias MPO, Monteiro HDA. Equine rabies in the southern region of Piauí State. Acta Scientiae Veterinariae 48, 101394.
                doi: 10.22456/1679-9216.101394google scholar: lookup
              62. Singh R, Singh KP, Cherian S, Saminathan M, Kapoor S, Manjunatha Reddy G. Rabies–epidemiology, pathogenesis, public health concerns and advances in diagnosis and control: A comprehensive review. Veterinary Quarterly 37, 212–251.
                doi: 10.1080/01652176.2017.1343516pubmed: 28643547google scholar: lookup
              63. Sodré DNA, Rossi GAM, Mathias LA, De Andrade Belo MA. Epidemiology and control of rabies in cattle and equines in Rondônia State, a Brazilian’s Legal Amazon Area. Animals 13, 2974.
                doi: 10.3390/ani13182974pmc: PMC10526067pubmed: 37760375google scholar: lookup
              64. Stringer AP, Christley RM, Bell C, Gebreab F, Tefera G, Reed K. Owner reported diseases of working equids in central Ethiopia. Equine Veterinary Journal 49, 501–506.
                doi: 10.1111/evj.12633pmc: PMC5484383pubmed: 27565130google scholar: lookup
              65. Susan P. Family rhabdoviridae in viruses: From understanding to investigation. 2nd edn., Academic Press, London.
              66. Suu-Ire RD, Obodai E, Bonney J, Bel-Nono SO, Ampofo W, Kelly TR. Viral zoonoses of national importance in Ghana: Advancements and opportunities for enhancing capacities for early detection and response. Journal of Tropical Medicine 2021, 8938530.
                doi: 10.1155/2021/8938530pmc: PMC7860970pubmed: 33574853google scholar: lookup
              67. Tenzin, Dhand NK, Ward MP. Patterns of rabies occurrence in Bhutan between 1996 and 2009. Zoonoses and Public Health 58(7), 463–471.
                doi: 10.1111/j.1863-2378.2011.01393.xpubmed: 21843156google scholar: lookup
              68. Tolouei M, Mobarak H, Mostofi S. A case report of rabies in a horse in Tabriz, Iran. Journal of Zoonotic Diseases 2, 35–42.
              69. Yadav S. Animal rabies in Nepal and Raccon Rabies in Albany County, New York. MSc Thesis, College of Veterinary medicine, Kansas State University.

              Citations

              This article has been cited 1 times.
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