Radiographic and microscopic correlation of diffuse interstitial and bronchointerstitial pulmonary patterns in the caudodorsal lung of adult thoroughbred horses in race training.
Abstract: Complete thoracic radiographic examinations were performed on 7 horses ranging in age from 24 to 60 months, followed by in-situ lung fixation. Radiographs were examined by 3 radiologists for the presence, degree and distribution of generalised pulmonary patterns within a region of interest in the caudodorsal lung. Pulmonary tissue was obtained from 12 sites within a designated volume of interest in the caudodorsal lung, corresponding to the area of interest evaluated radiographically, and examined for the presence, character and severity of microscopic lesions. Radiographic findings within the volume of interest consisted of mild to moderate bronchial, bronchointerstitial, or interstitial pulmonary patterns. Interstitial and bronchointerstitial radiographic findings were related to severity of peribronchiolar mononuclear cell infiltrates, the degree of bronchiolar mucosal plication, and alveolar capillary and peribronchial blood vessel erythrocyte content. The severity of the interstitial radiographic pattern was inversely associated with the perceived diagnostic quality of the radiographic examinations. There was no evidence of spatial variation in the severity of the microscopic changes examined in this limited pulmonary region. Inter-rater reliability between radiologists was good in the assessment of diagnostic quality of the radiographic examinations but poor in assessing severity of the primary generalised pulmonary patterns within the radiographic region of interest.
Publication Date: 1993-07-01 PubMed ID: 8354214DOI: 10.1111/j.2042-3306.1993.tb02966.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigated the relationship between radiographic images and microscopic findings of certain lung conditions in adult thoroughbred horses in race training. Detailed study included examining thoracic radiographs and lung tissue samples of seven horses.
Methodology
- The horses involved in the study range in age from 24 to 60 months.
- After thorough thoracic radiographic examinations, the lungs of the horses were fixed in-situ or in their natural position.
- Three professional radiologists evaluated the lung radiographs to identify the presence, degree and distribution of pulmonary patterns within a specifically chosen area in the caudodorsal lung.
- They also collected pulmonary tissue samples from 12 locations within the caudodorsal lung to correspond to the region observed radiographically. The samples were analyzed for the presence, type, and severity of microscopic lesions.
Results
- The findings of radiographic examinations within the observed lung area showed mild to moderate bronchial, bronchointerstitial, or interstitial pulmonary patterns.
- Near the bronchioles, or smaller air tubes, mononuclear cell infiltrates were present. The alveolar capillary and peribronchial blood vessel erythrocyte content and degree of bronchiolar mucosal plication, or folding, were related to these radiographic findings of interstitial and bronchointerstitial abnormalities.
- The study showed that the severer the interstitial radiographic pattern, the lower the perceived diagnostic quality of the radiographic examination.
- No evidence showed any spatial variation in the severity of the microscopic changes examined in this limited lung region.
Interpretation and Conclusion
- The inter-rater agreement between radiologists was good in assessing the overall diagnostic quality of the radiographs. However, there was poor agreement in rating the severity of the general lung patterns within the specific radiographic region.
- This suggests that challenges may exist in correctly interpreting radiographs and assessing the severity of certain lung patterns.
Cite This Article
APA
Wisner ER, O'Brien TR, Lakritz J, Pascoe JR, Wilson DW, Tyler WS.
(1993).
Radiographic and microscopic correlation of diffuse interstitial and bronchointerstitial pulmonary patterns in the caudodorsal lung of adult thoroughbred horses in race training.
Equine Vet J, 25(4), 293-298.
https://doi.org/10.1111/j.2042-3306.1993.tb02966.x Publication
Researcher Affiliations
- Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
MeSH Terms
- Animals
- Breeding
- Bronchi / anatomy & histology
- Female
- Horses / anatomy & histology
- Horses / physiology
- Lung / anatomy & histology
- Lung / diagnostic imaging
- Male
- Physical Conditioning, Animal
- Radiography
Citations
This article has been cited 4 times.- Raulic J, Leung VS, Doss GA, Graham JE, Keller KA, Mans C, Sadar MJ, Vergneau-Grosset C, Pang DS. Development and Testing of a Sedation Scale for Use in Rabbits (Oryctolagus cuniculus). J Am Assoc Lab Anim Sci 2021 Sep 1;60(5):549-555.
- Barton AK, Schulze T, Doherr MG, Gehlen H. Influence of bronchoalveolar lavage on thoracic radiography in the horse. J Vet Sci 2018 Jul 31;19(4):563-569.
- Wagner MC, Hecker KG, Pang DSJ. Sedation levels in dogs: a validation study. BMC Vet Res 2017 Apr 18;13(1):110.
- Doucet MY, Viel L. Clinical, radiographic, endoscopic, bronchoalveolar lavage and lung biopsy findings in horses with exercise-induced pulmonary hemorrhage. Can Vet J 2002 Mar;43(3):195-202.
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