Recovery Quality After Romifidine Versus Detomidine Infusion During Isoflurane Anesthesia in Horses.
Abstract: To examine the influence of detomidine or romifidine on recovery quality from isoflurane anesthesia, 78 anesthetic records were reviewed, from horses that had received romifidine (group R) during premedication [80-120 μg kg IV], anesthetic maintenance (40 μg kg hour IV), and recovery (20 μg kg IV) or detomidine (group D), at doses of 10-20 μg kg IV, 5 μg kg hour IV, and 2.5 μg kg IV, respectively. Duration of the different recovery phases, the number of attempts to sternal and standing, scores for transition to standing (TrSta), balance and coordination once standing (BC), and final recovery score (FS) were compared between groups using a Mann-Whitney U-test, independent t-test, or chi-squared test, as appropriate (alpha 0.05). Parametric data are represented as the mean ± standard deviation, and nonparametric data as the median (interquartile range). Compared with group D (25 horses), horses in group R (53 horses) needed significantly fewer attempts to achieve sternal recumbency [R 1 (1-1) vs. D 1 (1-2)], remained significantly longer in sternal recumbency [R 10 (3-14,5) vs. D 5 (1-9,5) minutes], needed significantly less attempts to stand [R 1 (1-1) vs. D 2 (1-4)], and a significantly shorter time to stand after making their first attempt [R 0 (0-0) vs. D 3 (0-6) minutes], with significantly better scores for TrSta, BC, and FS in group R. The results suggest that, at the doses used, romifidine provides a better recovery quality.
Copyright © 2020 Elsevier Inc. All rights reserved.
Publication Date: 2020-09-03 PubMed ID: 33077077DOI: 10.1016/j.jevs.2020.103243Google Scholar: Lookup
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Summary
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This research investigates how the use of two different drugs, romifidine and detomidine, influences the recovery quality of horses after being anesthetized with isoflurane. The study suggests that horses given romifidine recover better than those administered detomidine.
Introduction and Methodology
- The study reviewed 78 cases of horse anesthesia, comparing those given romifidine (Group R, 53 horses) and those given detomidine (Group D, 25 horses).
- The scientists considered variables such as: duration of different recovery phases, the number of attempts to reach sternal recumbency (lying on the chest) and standing up, and a set of recovery quality scores (transition to standing, balance and coordination once standing, and final recovery score).
- Analysis of these variables was performed using a mixture of statistical tests, such as Mann-Whitney U-test, independent t-test, or chi-squared test, as appropriate.
Results
- On average, horses in the romifidine group needed fewer attempts to lie on their chests, spent more time in this position, required fewer attempts to stand up, and stood up faster after their first attempt.
- This group also had better scores for transition to standing up, balance and coordination once standing, and final recovery score.
- The researchers observed significant differences between the two groups in each of these respects, suggesting that the results were unlikely to be due to random chance.
Conclusion
- The findings suggest that romifidine, at the tested doses, provides higher recovery quality than detomidine in horses after isoflurane anesthesia.
- However, as with all studies, it’s important to weigh the benefits and risks, and consider other factors such as the individual horse’s health status and the specific circumstances of anesthesia.
- Eventually, this research may contribute to changes in veterinary practice, potentially leading to improved anesthesia recovery for horses.
Cite This Article
APA
Alonso BB, La Rosa L, Carregaro AB, Gasthuys F, Schauvliege S.
(2020).
Recovery Quality After Romifidine Versus Detomidine Infusion During Isoflurane Anesthesia in Horses.
J Equine Vet Sci, 94, 103243.
https://doi.org/10.1016/j.jevs.2020.103243 Publication
Researcher Affiliations
- Faculty of Veterinary Medicine, Department of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium. Electronic address: bruna.alonso@ugent.be.
- Faculty of Veterinary Medicine, Department of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium.
- School of Animal Science and Food Engineering, Department of Veterinary Medicine, University of São Paulo, Pirassununga, São Paulo, Brazil.
- Faculty of Veterinary Medicine, Department of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium.
- Faculty of Veterinary Medicine, Department of Surgery and Anaesthesia of Domestic Animals, University of Ghent, Merelbeke, Belgium.
MeSH Terms
- Anesthesia / veterinary
- Anesthetics, Inhalation
- Animals
- Horses
- Imidazoles
- Isoflurane
Citations
This article has been cited 3 times.- Guerri G, Cerasoli I, Straticò P, De Amicis I, Giangaspero B, Varasano V, Paolini A, Carluccio A, Petrizzi L. The Clinical Effect of Xylazine Premedication in Water Buffalo Calves (Bubalus bubalis) Undergoing Castration under General Anaesthesia. Animals (Basel) 2021 Dec 1;11(12).
- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
- Okur S, Yanmaz LE, Senocak MG, Golgeli A, Turgut F, Orhun OT, Kocaman Y, Ersoz U. Comparison of the Effectiveness of Warmed Versus Room Temperature Intravenous Fluids Administration to Prevent Intraoperative Heat Loss in Anaesthetised Calves Undergoing Umbilical Herniorrhaphy. Vet Med Sci 2024 Nov;10(6):e70096.
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