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Home / Equine Research Bank / Equine Vet J / Recovery quality following a single post-anaesthetic dose of...
Equine veterinary journal2020; 52(5); 685-691; doi: 10.1111/evj.13238

Recovery quality following a single post-anaesthetic dose of dexmedetomidine or romifidine in sevoflurane anaesthetised horses.

Abstract: Post-anaesthetic sedation is administered to horses to improve recovery quality from inhalant anaesthesia and reduce the risk of catastrophic injury. A single dose of dexmedetomidine for this purpose has not been evaluated clinically. Objective: To determine whether dexmedetomidine improves recovery quality from sevoflurane anaesthesia compared to a previously studied dose of romifidine. Methods: Prospective, randomised, masked clinical trial. Methods: Ninety-nine, adult, client-owned horses anaesthetised for elective procedures completed the trial. Anaesthetic protocol was standardised. Horses were randomly assigned to receive either dexmedetomidine 1 mcg/kg bwt (D) or romifidine 20 mcg/kg bwt (R) intravenously at their first spontaneous breath in recovery. Recoveries were reviewed and independently assigned subjective visual analogue scale (VAS) scores (0-100 mm, worst to best) for overall quality and standing ataxia scores (1-4, none to severe) by two anaesthesiologists blinded to treatment group. Objective anaesthesia and recovery data were also recorded. Comparisons were made using the Chi-square, Wilcoxon rank sum, linear models or Welch-Satterthwaite two-sample t-test (P ≤ .05). Predictors of VAS score were analysed independent of treatment group. Results: There were no significant differences between groups except end-tidal sevoflurane (FE´Sevo) concentration and post-induction extra ketamine dosing. Including FE´Sevo and additional ketamine in the analysis as covariates, VAS scores and time to standing were not significantly different between groups. Increased age, not receiving a nerve block, increased duration of hypotension, and having a nervous temperament were significant predictors of VAS score. Conclusions: No universal recovery scale exists for inter-study comparisons. Conclusions: After sevoflurane anaesthesia, sedation with dexmedetomidine or romifidine provides clinically similar recovery time and quality.
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Publication Date: 2020-02-21 PubMed ID: 31975413DOI: 10.1111/evj.13238Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study explored if dexmedetomidine improves recovery quality from anaesthesia in horses compared to romifidine. The researchers found that both medications provide similar recovery time and quality.

Introduction and Methodology

In this clinical trial, the effect of two different sedatives, dexmedetomidine and romifidine, on the quality of recovery from sevoflurane anaesthesia in horses was evaluated.

  • The study was designed as a prospective, randomised, and masked clinical trial. This means the researchers designed the study in advance, randomly assigned subjects to different treatment groups, and blinded those observing the results to what treatments the subjects received.
  • Ninety-nine client-owned adult horses were included in the study. All of these horses were anaesthetised for elective procedures, and the anaesthetic protocol was standardised, or kept the same, across all horses.
  • The horses were divided into two groups, with one group receiving dexmedetomidine and the other receiving romifidine. These drugs were administered intravenously at the first spontaneous breath in the recovery period.
  • The quality of recovery was evaluated through the use of a visual analogue scale (VAS), subjective scores given by two anaesthesiologists who were blinded to the treatment group.
  • The study also considered several other factors such as end-tidal sevoflurane concentration, additional ketamine dosage, age, nerve block application, duration of hypotension, and temperament.

Results

Data analysis showed that overall the quality of post-anesthesia recovery was not significantly different between the two groups.

  • No significant differences were found in VAS scores and time to standing (a measure of recovery time) between the two drug groups.
  • The only aspects in which the groups differed were end-tidal sevoflurane concentration and extra ketamine dosages given after anaesthetic induction.
  • Some factors such as increased age, not receiving a nerve block, a longer duration of hypotension and displaying a nervous temperament, were all found to influence VAS scores, regardless of the anaesthesia regimen used.

Conclusion

The conclusion drawn from this research study is that whether horses receive dexmedetomidine or romifidine for post-anaesthetic sedation after sevoflurane anaesthesia does not create significantly different outcomes in terms of recovery time and quality. This finding suggests that both dexmedetomidine and romifidine are effective and can be used interchangeably to improve recovery quality in horses after sevoflurane anesthesia. The authors also indicate the need for a universal recovery scale to enable comparisons between different studies.

Cite This Article

APA
Hector RC, Rezende ML, Mama KR, Hess AM. (2020). Recovery quality following a single post-anaesthetic dose of dexmedetomidine or romifidine in sevoflurane anaesthetised horses. Equine Vet J, 52(5), 685-691. https://doi.org/10.1111/evj.13238

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 52
Issue: 5
Pages: 685-691

Researcher Affiliations

Hector, Rachel C
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Rezende, Marlis L
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Mama, Khursheed R
  • Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Hess, Ann M
  • Department of Statistics, College of Natural Sciences, Colorado State University, Fort Collins, CO, USA.

MeSH Terms

  • Anesthetics, Inhalation
  • Animals
  • Dexmedetomidine
  • Horses
  • Imidazoles
  • Prospective Studies
  • Sevoflurane

References

This article includes 23 references
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Citations

This article has been cited 2 times.
  1. Du D, Qiao Q, Guan Z, Gao YF, Wang Q. Combined sevoflurane-dexmedetomidine and nerve blockade on post-surgical serum oxidative stress biomarker levels in thyroid cancer patients.. World J Clin Cases 2022 Apr 6;10(10):3027-3034.
    doi: 10.12998/wjcc.v10.i10.3027pubmed: 35647114google scholar: lookup
  2. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
    doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
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