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Veterinary world2022; 15(6); 1530-1534; doi: 10.14202/vetworld.2022.1530-1534

Reduction of the nematode egg reappearance period in horses after anthelmintic therapy.

Abstract: Anthelmintics are used to control equine nematodes. However, helminth resistance to regularly used drugs is a well-known challenge. Among tests to assess effective control and monitor resistance, the most common is the fecal egg count reduction test (FECRT). In the absence of reliable FECRT results, the nematode egg reappearance period (ERP) is taken into account. This study aimed to examine horses from farms around the Moscow Region to assess nematode resistance through ERP after therapy. Unassigned: In the first stage, fecal samples from 280 horses were examined by the flotation method with a sodium nitrate solution. The eggs per gram (EPG) in feces were counted using the modified McMaster technique. One hundred and forty out of 280 horses were selected for further work. Five groups were formed: Two groups of horses infected with strongyles (n = 50) and three groups with Parascaris equorum (n = 90). Therapy against strongyles was performed with albendazole and ivermectin. Therapy for parascaridosis was performed with fenbendazole, ivermectin, and aversectin C. Samples from the horses in each group were taken on the 14th day (2 weeks), 28th day (4 weeks), 42nd day (6 weeks), 56th day (8 weeks), and 84th day (12 weeks) after treatment, and the amount of EPG in each sample was determined. Unassigned: Overall, nematodes were found in 65% of the horses examined. P. equorum was most frequently recorded (42.1%) followed by Strongylidae gen. spp. (27.9%). The strongyles ERP after therapy with albendazole and ivermectin was estimated on 42 days (6 weeks). The growth of P. equorum eggs in the feces was observed from the 56th day (8 weeks) after therapy with fenbendazole, from the 42nd day (6 weeks) after therapy with ivermectin, and was observed from the 84th day (12 weeks) after the use of aversectin. Unassigned: Our study shows widespread reductions in nematode ERPs across the Moscow Region after ivermectin therapy in horses, suggesting that additional monitoring of these farms is needed for effective control of anthelmintic resistance.
Copyright: © Baranova, et al.
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Publication Date: 2022-06-24 PubMed ID: 35993067PubMed Central: PMC9375206DOI: 10.14202/vetworld.2022.1530-1534Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research is centered on the study of resistance to anti-parasite medication among equine (horse) nematodes, specifically measuring the period where nematode eggs reappear post-treatment in the Moscow region.

Objective of the Research

  • The study aimed to assess the level of nematode resistance to anthelmintic (anti-parasitic) drugs in horses. This was done by examining the “nematode egg reappearance period” (ERP) after the horses underwent therapy.

Method of the Research

  • The initial phase of the research involved examining fecal samples from 280 horses using the flotation method with a sodium nitrate solution. The egg per gram (EPG) in each fecal sample was counted using a method known as the modified McMaster technique.
  • From these 280 horses, 140 were selected for more study and grouped into five. Two groups were infected with strongyles, while the other three had parascaridosis.
  • Therapies were administered accordingly with albendazole and ivermectin being used for strongyles, and fenbendazole, ivermectin, and aversectin C used for the parascaridosis infected horses.
  • The researchers collected samples 2 weeks, 4 weeks, 6 weeks, 8 weeks, and 12 weeks after the treatment. The EPG count was determined in each sample collected.

Findings of the Research

  • The examination identified nematodes in 65% of the horses studied. Parascaridosis was most common (42.1%), followed by strongyles species (27.9%).
  • The ERP for horses treated for strongyles with albendazole and ivermectin was estimated at about 6 weeks.
  • The parascaridosis-infected horses began showing signs of the eggs in the feces from 8 weeks, 6 weeks, and 12 weeks after treatment with fenbendazole, ivermectin, and aversectin C respectively.

Conclusion of the Research:

  • The research revealed a significant reduction in nematode ERPs among horses in the Moscow Region post-ivermectin therapy. The researchers concluded that ongoing monitoring of these farms is crucial to effectively control anthelmintic resistance.

Cite This Article

APA
Baranova MV, Panova OA, Polukhina DN, Panova DS. (2022). Reduction of the nematode egg reappearance period in horses after anthelmintic therapy. Vet World, 15(6), 1530-1534. https://doi.org/10.14202/vetworld.2022.1530-1534

Publication

Veterinary world
ISSN: 0972-8988
NlmUniqueID: 101504872
Country: India
Language: English
Volume: 15
Issue: 6
Pages: 1530-1534

Researcher Affiliations

Baranova, Maria V
  • Laboratory of Biology and Biological basis of Preventive Measures, Federal State Budget Scientific Institution "Federal Scientific Centre VIEV" (FSC VIEV), St. B. Cheryomushkinskaya, 28, Moscow, 117218, Russia.
Panova, Olga A
  • Laboratory of Biology and Biological basis of Preventive Measures, Federal State Budget Scientific Institution "Federal Scientific Centre VIEV" (FSC VIEV), St. B. Cheryomushkinskaya, 28, Moscow, 117218, Russia.
Polukhina, Daria N
  • Laboratory of Biology and Biological basis of Preventive Measures, Federal State Budget Scientific Institution "Federal Scientific Centre VIEV" (FSC VIEV), St. B. Cheryomushkinskaya, 28, Moscow, 117218, Russia.
Panova, Daria S
  • Laboratory of Biology and Biological basis of Preventive Measures, Federal State Budget Scientific Institution "Federal Scientific Centre VIEV" (FSC VIEV), St. B. Cheryomushkinskaya, 28, Moscow, 117218, Russia.

Conflict of Interest Statement

The authors declare that they have no competing interests.

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Citations

This article has been cited 3 times.
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