Regenerative medicine for the treatment of Teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors.
Abstract: The aim of the present study was to evaluate the safety and the clinical outcome of platelet-rich plasma for the treatment of teno-desmic injures in competition horses. Methods: From January 2009 to December 2011, 150 sport horses suffering from teno-desmic injuries were treated with no-gelled platelet-concentrate. Results: No horse showed any major adverse reaction as a result of the procedure. Full healing was obtained for 81% of the horses. Twelve percent had clinical improvement and only 7% a failure. Eight percent of cases of relapse were observed. No statistically significant correlation existed between clinical outcome and the area of the lesion. A statistically significant correlation existed between the clinical outcome and the age of the horse. Conclusions: Treatment with platelet-derived growth factors leads to the formation of a tendon with normal morphology and functionality, which translate in the resumption of the agonistic activity for the horses we treated.
Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.
Publication Date: 2014-11-16 PubMed ID: 25398809
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- Journal Article
Summary
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This research investigates the safety and effectiveness of using platelet-rich plasma to treat tendon and ligament injuries in competition horses, revealing that the treatment helps in full recovery of 81% of the cases and does not result in any major adverse reaction.
Introduction to the Research
- The research aimed to assess the impact of using platelet-rich plasma, also known as platelet-derived growth factors, in treating injuries to the tendons and ligaments (teno-desmic injuries) in horses participating in sports competitions.
Methods Used in the Research
- The method involved treating 150 sport horses afflicted with teno-desmic injuries with a non-gelled platelet concentrate.
- The treatment was administered from January 2009 to December 2011 to form a substantial sample for the analysis.
Results of the Research
- None of the treated horses exhibited any significant adverse reactions due to the medical procedure.
- 81% of the horses achieved full recovery after getting the treatment. Hence, platelet-rich plasma proved to be an effective treatment for most cases.
- 12% of the horses showed clinical improvement, indicating partial effectiveness of the treatment in these cases.
- Only 7% of the cases could not achieve desired improvement, presenting the treatment as a failure.
- Relapse was observed in 8% of the cases after the treatment.
- No statistically significant correlation was found between the outcome of the clinical treatment and the area of the lesion.
- A conspicuous correlation was noted between the age of the horse and the outcome of the treatment, with age playing a significant role in the effectiveness of the treatment.
Conclusions Drawn from the Research
- The research concluded that treating teno-desmic injuries in horses with platelet-derived growth factors yields a tendon with normal morphology and functionality.
- As a result of the successful treatment, the horses were able to resume their participation in competitive activities.
Cite This Article
APA
Scala M, Lenarduzzi S, Spagnolo F, Trapasso M, Ottonello C, Muraglia A, Barla A, Squillario M, Strada P.
(2014).
Regenerative medicine for the treatment of Teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors.
In Vivo, 28(6), 1119-1123.
Publication
Researcher Affiliations
- Department of Plastic and Reconstructive Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale Per La Ricerca Sul Cancro, Genova, Italy.
- Department of Medical and Veterinary Sciences, University of Parma, Parma, Italy.
- Department of Plastic and Reconstructive Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale Per La Ricerca Sul Cancro, Genova, Italy.
- Department of Plastic and Reconstructive Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale Per La Ricerca Sul Cancro, Genova, Italy trapassomaria1984@gmail.com.
- Department of Experimental Medicine, University of Genova, Genova, Italy.
- Department of Experimental Medicine, University of Genova, Genova, Italy.
- Department of Computer and Information Science (DISI), University of Genova, Genova, Italy.
MeSH Terms
- Animals
- Horse Diseases / diagnostic imaging
- Horse Diseases / therapy
- Horses
- Platelet-Derived Growth Factor / therapeutic use
- Platelet-Rich Plasma
- Regenerative Medicine / methods
- Treatment Outcome
- Ultrasonography
- Wounds and Injuries / veterinary
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