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Relationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions.
Abstract: Establishing the osteoarticular status of the horse is often performed by means of radiological screening of the animals. Widespread blood sampling could reveal to be an interesting alternative to this procedure which is time consuming and sometimes technically difficult. The aim of this study was to investigate the relationship between the radiological status of the horses and the levels of biochemical markers of cartilage degradation and synovial inflammation. A specific radiological scoring and classification system was therefore developed and applied on 63 stallions presented for studbook admission. Additionally, groups of horses were established according to the occurrence of osteochondrosis, degenerative joint disease and distal interphalangeal joint effusion. Insulin growth factor-I, myeloperoxidases, Coll2-1 and Coll2-1NO(2) were used as blood markers. The combination of the blood parameters did not seem to correlate with the used scoring system. Coll2-1NO(2) levels however tended to increase with poorer radiological class and this could therefore potentially be a useful predictor of the osteoarticular status in the horse. Coll2-1 levels were significantly higher in the degenerative joint disease group. A high percentage of horses with distal interphalangeal joint effusion was present in this study and was associated with decreased IGF-I and increased Coll2-1 levels.
Publication Date: 2009-03-18 PubMed ID: 19298987DOI: 10.1016/j.rvsc.2009.02.002Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research is aimed at exploring the relationship between radiological scores and biochemical markers that indicate cartilage degradation and synovial inflammation in Warmblood stallions. The study’s results suggest that a specific blood marker, known as Coll2-1NO(2), may be a useful far-off indicator of the osteoarticular health status in horses.
Objective and Methodology
- The focus of this study is to assess the potential connection between the osteoarticular status (relating to bones and joints) of Warmblood stallions (a type of horse breed) and the presence of specific biochemical markers in the blood.
- This is pursued as a possible alternative to the often time-consuming and technical procedure of radiological screening
- A unique radiological scoring and categorizing system was created and utilized on 63 stallions presented for inclusion in a studbook.
Biochemical Markers
- The researchers employed biomarkers like Insulin growth factor-I, myeloperoxidases, Coll2-1, and Coll2-1NO(2) as blood markers.
- The horses were sorted into groups based on the appearance of osteochondrosis (a disorder affecting the growth of bone and cartilage), degenerative joint disease, and distal interphalangeal joint effusion (swelling in a specific joint in the lower limb).
Study Results
- The results showed that the overall combination of blood parameters did not correspond well with the designated radiological scoring method.
- However, it was observed that levels of Coll2-1NO(2) tended to increase with degraded radiological classification, indicating it could potentially serve as a useful predictor of osteoarticular status in horses.
- The group of horses with degenerative joint disease showed a substantial elevation in Coll2-1 levels.
- A significant number of horses with distal interphalangeal joint effusion were observed part of this study, and this condition correlated with diminished Insulin Growth Factor-I (IGF-I) and increased Coll2-1 levels.
Cite This Article
APA
Verwilghen D, Busoni V, Gangl M, Franck T, Lejeune JP, Vanderheyden L, Detilleux J, Grulke S, Deberg M, Henrotin Y, Serteyn D.
(2009).
Relationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions.
Res Vet Sci, 87(2), 319-328.
https://doi.org/10.1016/j.rvsc.2009.02.002 Publication
Researcher Affiliations
- Department of Clinical Sciences, Equine Clinic, Faculty of Veterinary Medicine of Liege, B-4000 Liege, Belgium. denis.verwilghen@ulg.ac.be
MeSH Terms
- Animals
- Biomarkers / metabolism
- Bone and Bones / diagnostic imaging
- Bone and Bones / metabolism
- Horse Diseases / diagnostic imaging
- Horse Diseases / metabolism
- Horses / physiology
- Joint Diseases / diagnostic imaging
- Joint Diseases / metabolism
- Joint Diseases / veterinary
- Joints / metabolism
- Male
- Osteochondrosis / diagnostic imaging
- Osteochondrosis / metabolism
- Osteochondrosis / veterinary
- Radiography / methods
- Radiography / veterinary
Citations
This article has been cited 7 times.- Fradinho MJ, Mateus L, Bernardes N, Bessa RJB, Caldeira RM, Ferreira-Dias G. Growth patterns, metabolic indicators and osteoarticular status in the Lusitano horse: A longitudinal study. PLoS One 2019;14(7):e0219900.
- Turlo AJ, Cywinska A, Frisbie DD. Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population. BMC Vet Res 2019 Feb 26;15(1):66.
- Fawzy RM, Hashaad NI, Mansour AI. Decrease of serum biomarker of type II Collagen degradation (Coll2-1) by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis. Eur J Rheumatol 2017 Jun;4(2):93-97.
- Mirza MH, Bommala P, Richbourg HA, Rademacher N, Kearney MT, Lopez MJ. Gait Changes Vary among Horses with Naturally Occurring Osteoarthritis Following Intra-articular Administration of Autologous Platelet-Rich Plasma. Front Vet Sci 2016;3:29.
- Turło A, Cywińska A, Czopowicz M, Witkowski L, Niedźwiedź A, Słowikowska M, Borowicz H, Jaśkiewicz A, Winnicka A. The Effect of Different Types of Musculoskeletal Injuries on Blood Concentration of Serum Amyloid A in Thoroughbred Racehorses. PLoS One 2015;10(10):e0140673.
- Baccarin RY, Pereira MA, Roncati NV, Bergamaschi RR, Hagen SC. Development of osteochondrosis in Lusitano foals: a radiographic study. Can Vet J 2012 Oct;53(10):1079-84.
- Verwilghen DR, Martens A, Busschers E, Franck T, Deberg M, Henrotin Y, Vanderheyden L, Serteyn D. Coll2-1, Coll2-1NO2 and myeloperoxidase concentrations in the synovial fluid of equine tarsocrural joints affected with osteochondrosis. Vet Res Commun 2011 Oct;35(7):401-8.
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