Relationship between colloid osmotic pressure and plasma protein concentration in cattle, horses, dogs, and cats.
Abstract: The relationship between colloid osmotic pressure (COP) and protein concentration was investigated for purified proteins and plasma samples obtained from cattle, horses, dogs, and cats. At equivalent concentrations, bovine albumin exerted a COP that exceeded that of gamma-globulins by a mean factor of 4.4. Similar relationships between COP and protein were observed in the other species. Consequently, for a given total protein concentration, COP was dependent on the albumin/gamma-globulins ratio. A commonly used nomogram for estimating COP from protein concentration, the Landis-Pappenheimer equation, did not provide reliable results for plasma samples from these species.
Publication Date: 1992-12-01 PubMed ID: 1282310
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article investigates the relation between colloid osmotic pressure (COP) and protein concentration in different animal species, specifically cattle, horses, dogs, and cats. It concludes that COP in these animals depends more on the ratio of albumin to gamma-globulins at a particular protein concentration and suggests the Landis-Pappenheimer equation may not accurately estimate COP.
Study Purpose and Methodology
- Researchers in this scientific study aimed to assess the connection between colloid osmotic pressure (COP) and protein concentration in cattle, horses, dogs, and cats.
- The study evaluated the COP exerted by specific proteins and plasma samples procured from the aforementioned species.
- The research was specifically interested in analyzing the potential differences in COP as per bovine albumin and gamma-globulins, two key kinds of proteins existing in blood plasma.
Findings and Conclusions
- The key finding emerged that, at consistent concentrations, bovine albumin’s COP was substantially higher than that of gamma-globulins – an average difference by a factor of 4.4.
- This dependency of COP on the ration between albumin and gamma-globulins was further observed in all other studied animal species.
- Therefore, the overall conclusion found that, given a specific concentration of total protein, the COP depends heavily on the ratio of albumin to gamma-globulins.
Critique of the Landis-Pappenheimer equation
- Within this study, the researchers assessed the utility of the commonly used nomogram called the Landis-Pappenheimer equation. This equation is usually used to predict the COP derived from protein concentration.
- However, the study’s findings showed that this equation did not provide reliable results when used for the plasma samples obtained from the studied species – cattle, horses, dogs, and cats.
- This suggests that the Landis-Pappenheimer equation may have limitations in its utility across various species and calls for more precise methods of COP estimation.
Cite This Article
APA
Thomas LA, Brown SA.
(1992).
Relationship between colloid osmotic pressure and plasma protein concentration in cattle, horses, dogs, and cats.
Am J Vet Res, 53(12), 2241-2244.
Publication
Researcher Affiliations
- Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602.
MeSH Terms
- Animals
- Animals, Domestic / blood
- Blood Proteins / analysis
- Cats / blood
- Cattle / blood
- Dogs / blood
- Horses / blood
- Models, Biological
- Osmotic Pressure
- Serum Albumin / analysis
- gamma-Globulins / analysis
Citations
This article has been cited 8 times.- Ito T, Ota T, Kono R, Miyaoka Y, Ishibashi H, Komori M, Yasukawa A, Kanno Y, Miki N. Pump-Free Microfluidic Hemofiltration Device. Micromachines (Basel) 2021 Aug 20;12(8).
- Hall NH, Hall JS, Wiedner E, Stacy NI, Bandt C, Isaza R. Oncotic pressure and the effects of water deprivation in healthy captive Asian elephants. J Vet Diagn Invest 2019 Jul;31(4):572-575.
- Hooijberg EH, Miller M, Cray C, Buss P, Steenkamp G, Goddard A. Serum protein electrophoresis in healthy and injured southern white rhinoceros (Ceratotherium simum simum). PLoS One 2018;13(7):e0200347.
- Lawrence J, Cameron D, Argyle D. Species differences in tumour responses to cancer chemotherapy. Philos Trans R Soc Lond B Biol Sci 2015 Jul 19;370(1673).
- Martinez MN. Factors influencing the use and interpretation of animal models in the development of parenteral drug delivery systems. AAPS J 2011 Dec;13(4):632-49.
- Wendt-Hornickle EL, Snyder LB, Tang R, Johnson RA. The effects of lactated Ringer's solution (LRS) or LRS and 6% hetastarch on the colloid osmotic pressure, total protein and osmolality in healthy horses under general anesthesia. Vet Anaesth Analg 2011 Jul;38(4):336-43.
- Michaletos A, Breytenbach M, Zeiler GE. Effects of haemorrhage and lactated Ringer's solution or tetrastarch 130/0.4 resuscitation on colloidal osmotic pressure and osmolality in cats. J Feline Med Surg 2025 Apr;27(4):1098612X251320299.
- Mesa SM, Megerssa YC. Comparison of biuret and refractometery method for serum total protein measurements in cattle and goat. BMC Res Notes 2024 Aug 23;17(1):234.
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