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Home / Equine Research Bank / Can Vet J / Relationship of serum total calcium to serum albumin in dogs...
The Canadian veterinary journal = La revue veterinaire canadienne1993; 34(6); 360-364;

Relationship of serum total calcium to serum albumin in dogs, cats, horses and cattle.

Abstract: A retrospective study was performed in order to assess the relationship between serum calcium and serum albumin concentrations in domestic animals. Results of 9041 canine, 1564 feline, 2917 equine, and 613 bovine serum samples from hospitalized patients were examined by regression analysis. Subpopulations of cases with concurrent elevations in creatinine or that were less than six months of age were evaluated separately. Statistically significant linear relationships between calcium and albumin concentrations were established for each species (p <0.05). The coefficients of determination (r(2)) were 0.169 for dogs, 0.294 for cats, 0.222 for horses, and 0.032 for cattle. The correlation coefficients (r) computed were: dogs = 0.411, cats = 0.543, horses = 0.471, cattle = 0.182. Neither increases in creatinine concentration nor juvenile age appreciably influenced the relationship between calcium and albumin concentrations. Interspecies variation was marked, and a strong correlation between calcium and albumin concentrations was not established in any species.
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Publication Date: 1993-06-01 PubMed ID: 17424241PubMed Central: PMC1686560
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study primarily focuses on establishing the correlation between serum calcium and serum albumin levels in domestic animals including dogs, cats, horses, and cattle, but fails to find a strong correlation in any of these species.

Introduction and Methodology

  • The study undertook a retrospective analysis of serum samples collected from hospitalized patients belonging to four major domesticated animals – dogs, cats, horses, and cattle.
  • The analysis examined 9041 samples from dogs, 1564 from cats, 2917 from horses, and 613 from cattle.
  • The study further segregated the data to look at the cases experiencing elevated creatinine levels and those that were less than six months old, in order to factor in any potential variabilities that might affect the relationship between the serum calcium and albumin levels.

Results and Discussion

  • The analysis revealed that there were statistically significant linear relationships between calcium and albumin levels for each species, validating that an increase in albumin concentration has a consequential impact on calcium levels.
  • The coefficient of determination (r(2)), indicating the strength of the relationship between the two variables, varied across the species with dogs at 0.169, cats at 0.294, horses at 0.222, and cattle at a notably low 0.032.
  • The correlation coefficient (r), signaling the direction and strength of the linear relationship between albumin and calcium, was also calculated. Dogs showed a correlation of 0.411, cats had a higher value of 0.543, horses had 0.471, and cattle had a substantially lower correlation of 0.182.
  • Interestingly, the study found that neither high creatinine levels nor juvenile age of the animals significantly influenced the correlation between the serum calcium and albumin levels.

Conclusions

  • The research concluded that despite a statistically significant relationship existing between serum calcium and albumin concentrations in the selected species, none of them displayed a strong correlation.
  • The observed interspecies differences were pronounced, indicating that the relationship between these two variables may be unique for each animal species. This means the generalizing of findings across species could be misleading.

Cite This Article

APA
Bienzle D, Jacobs RM, Lumsden JH. (1993). Relationship of serum total calcium to serum albumin in dogs, cats, horses and cattle. Can Vet J, 34(6), 360-364.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 34
Issue: 6
Pages: 360-364

Researcher Affiliations

Bienzle, D
    Jacobs, R M
      Lumsden, J H

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        Citations

        This article has been cited 5 times.
        1. Thongrueang N, Yang SF, Ke GM, Hsu HY, Lee HH. Albumin and other metabolic parameters as potential indicators of purulent vaginal discharge in dairy cows during the transition period.. J Vet Med Sci 2023 Jul 1;85(7):743-750.
          doi: 10.1292/jvms.23-0081pubmed: 37225447google scholar: lookup
        2. De Witte F, Klag A, Chapman P. Adjusted calcium concentration as a predictor of ionized hypocalcemia in hypoalbuminemic dogs.. J Vet Intern Med 2021 Sep;35(5):2249-2255.
          doi: 10.1111/jvim.16247pubmed: 34424577google scholar: lookup
        3. Constable P, Trefz FM, Stämpfli H. Effects of pH and the plasma or serum concentrations of total calcium, chloride, magnesium, l-lactate, and albumin on the plasma ionized calcium concentration in calves.. J Vet Intern Med 2019 Jul;33(4):1822-1832.
          doi: 10.1111/jvim.15509pubmed: 31059164google scholar: lookup
        4. van den Broek DH, Chang YM, Elliott J, Jepson RE. Chronic Kidney Disease in Cats and the Risk of Total Hypercalcemia.. J Vet Intern Med 2017 Mar;31(2):465-475.
          doi: 10.1111/jvim.14643pubmed: 28190275google scholar: lookup
        5. Schenck PA, Chew DJ. Prediction of serum ionized calcium concentration by serum total calcium measurement in cats.. Can J Vet Res 2010 Jul;74(3):209-13.
          pubmed: 20885845
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