Relationships between lymphoid nodules and lymph sinuses in lymph nodes: a study in horses.
Abstract: Secondary lymphoid nodules in lymph nodes of the horse are surrounded by a network of lymph sinuses, including the subcapsular sinus and its extensions around tabeculae, tubular and tubule-like sinuses deeper in the cortex, and sinuses between cord-like projections of cortical tissue. The precise role of this close association between sinuses and nodules in the transport of immune complexes, cells and cytokines is not known.
Publication Date: 1991-10-01 PubMed ID: 1810934PubMed Central: PMC1260533
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research paper analyses the relationship between lymphoid nodules and lymph sinuses in horses. The study particularly focuses on how the arrangement of these structures in the lymph nodes of horses might potentially influence the transport of immune complexes, cells, and cytokines.
Overview of Lymphoid Nodules and Lymph Sinuses
- The study informs about the anatomical connection between the secondary lymphoid nodules and lymph sinuses within the lymph nodes of a horse.
- Lymphoid nodules are small masses of tissue found in parts of the body where an immune response is taking place. They are essential for the body’s defense against diseases.
- Lymph sinuses are channels existent within the lymph nodes that aid in the transportation of lymph, immune cells, and wastes within the lymphatic system.
The Relationship and Study Objective
- The lymphoid nodules are found to be surrounded by a network of lymph sinuses. This network includes the subcapsular sinus and its extensions around the trabeculae, and other sinuses located deeper within the cortex of the lymph nodes.
- Given this spatial arrangement, the authors were prompted to investigate whether these complexities have specific roles in the transportation of immune complexes, cells, and cytokines.
Purpose and Significance of the Study
- The exact role of the relationship between sinuses and nodules is still unknown, hence this study’s purpose is to try and clarify if there is a specific importance attached to the close association between these structures.
- If there is indeed a significant relationship, understanding it could aid in enhancing our knowledge about the functioning of the lymphatic system in animals, potentially enabling us to devise ways to improve its efficiency or treat lymphatic system-related diseases more effectively.
Cite This Article
APA
Heath TJ, Nikles SA.
(1991).
Relationships between lymphoid nodules and lymph sinuses in lymph nodes: a study in horses.
J Anat, 178, 39-43.
Publication
Researcher Affiliations
- Department of Anatomy, University of Queensland, Australia.
MeSH Terms
- Animals
- Female
- Horses / anatomy & histology
- Lymphoid Tissue / anatomy & histology
- Lymphoid Tissue / ultrastructure
- Male
- Microscopy, Electron, Scanning
References
This article includes 10 references
- Nikles SA, Heath TJ. Pathways of lymph flow from the intestine of the horse.. Anat Rec 1991 Apr;229(4):521-4.
- Heath TJ, Perkins NR. Pathways between lymph vessels and sinuses in lymph nodes: a study in horses.. Anat Rec 1989 Apr;223(4):420-4.
- van Rooijen N. The "in situ" immune response in lymph nodes: a review.. Anat Rec 1987 Aug;218(4):359-64.
- Spalding H, Heath T. Pathways of lymph flow through superficial inguinal lymph nodes in the pig.. Anat Rec 1987 Feb;217(2):188-95.
- Sainte-Marie G, Peng FS, Bélisle C. Overall architecture and pattern of lymph flow in the rat lymph node.. Am J Anat 1982 Aug;164(4):275-309.
- Sainte-Marie G, Peng FS. Evidence for the existence of a subsinus layer of the peripheral cortex in the lymph node of the rat.. Cell Tissue Res 1985;239(1):37-42.
- Perkins NR, Heath TJ. Pathways of lymph flow from superficial tissues in the legs of horses.. Res Vet Sci 1990 Jan;48(1):119-23.
- Tew JG, Mandel TE, Phipps RP, Szakal AK. Tissue localization and retention of antigen in relation to the immune response.. Am J Anat 1984 Jul;170(3):407-20.
- Szakal AK, Holmes KL, Tew JG. Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology.. J Immunol 1983 Oct;131(4):1714-27.
- Sainte-Marie G, Peng FS. Diffusion of a lymph-carried antigen in the fiber network of the lymph node of the rat.. Cell Tissue Res 1986;245(3):481-6.
Citations
This article has been cited 3 times.- Lowden S, Heath T. Lymphatic drainage from the distal small intestine in sheep. J Anat 1993 Aug;183 ( Pt 1)(Pt 1):13-20.
- Belz GT, Heath TJ. Pathways of blood flow to and through superficial lymph nodes in the dog. J Anat 1995 Oct;187 ( Pt 2)(Pt 2):413-21.
- Belz GT, Heath TJ. Lymph pathways of the medial retropharyngeal lymph node in dogs. J Anat 1995 Jun;186 ( Pt 3)(Pt 3):517-26.
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