Renal dysplasia in two adult horses: clinical and pathological aspects.

The research article discusses the occurrence of renal dysplasia in two adult horses which resulted in chronic renal failure. Renal dysplasia, worsened by severe interstitial pyelonephritis, was identified through renal biopsy and confirmed upon examination after death.

Overview and Background

• The research focuses on two adult horses suffering from renal dysplasia, a congenital abnormality of kidneys’ development ultimately leading to chronic renal failure.
• Renal dysplasia is reported to be relatively uncommon in horses compared to other species like dogs and humans.

The Cases: Clinical Signs and Diagnosis

• The two horses were examined upon showing catalytic signs of renal failure, including loss of appetite, excessive urination, and weight loss.
• Routine blood tests and ultrasonography were used initially for diagnosis, followed by renal biopsy for a more definitive diagnosis.
• The horses had both developed chronic renal failure as a complication of renal dysplasia. This was further complicated by a severe kidney infection, known as interstitial pyelonephritis.

The Findings: Renal Dysplasia and Interstitial Pyelonephritis

• Upon examination through renal biopsy, the horses were identified to have renal dysplasia, characterized by the presence of immature cells and tissues in the kidneys.
• This disease was further complicated by the development of severe interstitial pyelonephritis, a type of kidney infection that involves the spaces between kidney tubules.
• Both diagnoses were later confirmed on post mortem examinations.

Implications and Conclusion

• The study underscores the importance of early diagnosis and treatment of renal dysplasia in horses to prevent complications like chronic renal failure and severe kidney infection.
• Further research is deemed necessary to better understand the genetic and environmental causes of this disease in horses, as well as the development of more effective treatments.