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Home / Equine Research Bank / Surg Today / Repair of gastric defects with an equine pericardial patch.
Surgery today2014; 45(1); 83-90; doi: 10.1007/s00595-014-1072-4

Repair of gastric defects with an equine pericardial patch.

Abstract: The objective of this study was to test the efficacy of an equine pericardial patch for repairing full-thickness defects of the stomach wall. Methods: Circular defects, 1.5 cm in diameter, were created on the anterior wall of the stomach of 12 female New Zealand rabbits. The defects were repaired by an equine pericardial patch. After euthanasia at different time intervals (3 days to 8 weeks) a macroscopic evaluation of the abdominal cavity (including adhesion scoring), mechanical testing and a histological examination of the stomach were performed. Results: The animals survived the surgical procedure and underwent an uneventful recovery until euthanasia. None of the patches failed. Adhesions were observed in all animals and were significant in 3/12 animals. Bursting pressure testing indicated that the repair was durable and that adequate strength to prevent patch failure was achieved by the second week. A histological examination showed gradual narrowing of the perforation site by mucosal and limited muscular regeneration. Conclusions: The equine pericardial patch was successfully used to repair a gastric defect in our experimental model, and it seems that it could have potential as a material suitable for further research concerning the repair of upper gastrointestinal defects.
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Publication Date: 2014-11-08 PubMed ID: 25380578DOI: 10.1007/s00595-014-1072-4Google Scholar: Lookup
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  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The researchers carried out a study to examine the effectiveness of an equine pericardial patch in repairing significant damages to the stomach wall, using rabbits as test subjects. The results showed that the patch was sturdy and after two weeks, it had gained enough strength to prevent further failure.

Methods

  • The experiment was conducted on 12 female New Zealand rabbits. In these rabbits, circular defects of 1.5 cm in diameter were created on the stomach’s anterior wall. These defects simulated severe damage to the stomach wall.
  • The defects were then repaired using an equine pericardial patch, which is a type of biological mesh prepared from the pericardium (sac surrounding the heart) of horses.
  • After certain periods ranging from 3 days to 8 weeks, the rabbits were euthanized and a comprehensive evaluation was performed, which included an assessment of the abdominal cavity, mechanical testing, and a histological examination of the stomach.

Results

  • All the tested animals survived the surgical procedure and recovered without complications until they were euthanized for evaluation.
  • There were no instances of patch failure observed, showing the stability and reliability of the equine pericardial patch.
  • Adhesions, or abnormal fusion of tissues, were observed in all animals post-surgery, with significant adhesion found in 3 out of the 12 subjects.
  • The repaired area withstood pressure testing, revealing that the strength of the patch in repairing the gastric defect was impressive and adequate enough to prevent failure by the end of the second week.
  • A histological examination displayed that a narrowing of the defect site occurred gradually over time due to the regeneration of mucosa and a limited amount of muscle.

Conclusions

  • In conclusion, this research indicates that the equine pericardial patch was successful in repairing gastric defects in the tested experimental model.
  • Given the positive results observed, the study suggests that equine pericardial patch could hold potential in further research for repairing defects in the upper gastrointestinal tract.

Cite This Article

APA
(2014). Repair of gastric defects with an equine pericardial patch. Surg Today, 45(1), 83-90. https://doi.org/10.1007/s00595-014-1072-4

Publication

Surgery today
ISSN: 1436-2813
NlmUniqueID: 9204360
Country: Japan
Language: English
Volume: 45
Issue: 1
Pages: 83-90

Researcher Affiliations

MeSH Terms

  • Animals
  • Bioprosthesis
  • Digestive System Surgical Procedures / methods
  • Disease Models, Animal
  • Female
  • Horses
  • Pericardium / transplantation
  • Rabbits
  • Stomach / surgery
  • Tissue Scaffolds

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