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Veterinary immunology and immunopathology1994; 42(1); 3-60; doi: 10.1016/0165-2427(94)90088-4

Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991.

Abstract: The First International Workshop on Equine Leucocyte Antigens was organized and convened for the purposes of identifying immunologically relevant cell surface molecules of equine leucocytes and establishing a system of nomenclature for those molecules. Participating members of the workshop represented the majority of laboratories world-wide engaged in the tasks of production and characterization of equine leucocyte and lymphocyte markers using monoclonal antibodies. The workshop confirmed the identification of several equine CD molecules described previously by individual laboratories, and in addition recognized antibodies identifying new CD molecules. The workshop also succeeded in fostering co-operation between laboratories around the world which study equine immunobiology. Equine CD molecules identified by the current battery of monoclonal antibodies include EqCD2, EqCD4, EqCD5, EqCD8, EqCD11a/18, EqCD13 and EqCD44. Other antibodies are markers for MHC class I and class II molecules, for B cells, granulocytes, macrophages, T cell subsets distinct from those defined by CD4 and CD8, and other sub-populations of horse leucocytes that do not have obvious counterparts in humans, rodents, or other species. Despite the progress made in the first workshop, there are still substantial gaps in the armory of reagents available to study equine leucocyte biology, and further definition of the structure, function, and genetics of the antigens identified by the workshop clusters (WC1, WC2 etc.) and other molecules of immunological importance will be a goal of future workshops. The study of equine immunobiology and resistance to disease also urgently requires the development of tools to study equine immunoglobulins and cytokines, and these needs will provide ample scope for future studies.
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Publication Date: 1994-07-01 PubMed ID: 7975180DOI: 10.1016/0165-2427(94)90088-4Google Scholar: Lookup
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  • Consensus Development Conference
  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • P.H.S.
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research is about the first international workshop held on Equine Leucocyte Antigens in Cambridge, UK in 1991. The workshop aimed to identify cell surface molecules of equine leucocytes and establish their naming system. The proceedings confirmed several equine CD molecules and identified new ones. Some gaps remain in the study of equine leucocyte biology which further workshops aim to fill.

Context and Aim of the workshop

  • The First International Workshop on Equine Leucocyte Antigens was designed with the intention to classify immunologically relevant cell surface molecules found on horse’s leucocytes and devise a nomenclature system for them.
  • Researchers and scientists from across the globe who are involved in the production and identification of equine leucocyte and lymphocyte markers were present in the workshop.

Results and Findings of the Workshop

  • At the workshop, several equine CD molecules that had been described in separate studies by individual laboratories were confirmed.
  • Furthermore, the delegates at the workshop were also able to recognize antibodies which identify new CD molecules.
  • Examples of such molecules include EqCD2, EqCD4, EqCD5, EqCD8, EqCD11a/18, EqCD13 and EqCD44. Other antibodies are markers for MHC class I and class II molecules, B cells, granulocytes, macrophages, and T cell subsets distinct from those defined by CD4 and CD8.
  • Additionally, they found markers for some sub-populations of horse leucocytes that do not have clear counterparts in humans, rodents, or other species.

Future Research and Conclusion

  • Despite the significant strides made at the conference, researchers acknowledged that there is still much work to be done in the area of equine leucocyte biology.
  • Further exploration is required into the structure, function, and genetic makeup of the antigens identified by the workshop clusters (WC1, WC2 etc.) alongside other molecules of immunological importance.
  • Also, to study equine immunobiology and its resistance to diseases, there is an urgent need for the development of tools for the detailed study of equine immunoglobulins and cytokines.

Cite This Article

APA
Kydd J, Antczak DF, Allen WR, Barbis D, Butcher G, Davis W, Duffus WP, Edington N, Grünig G, Holmes MA. (1994). Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991. Vet Immunol Immunopathol, 42(1), 3-60. https://doi.org/10.1016/0165-2427(94)90088-4

Publication

Veterinary immunology and immunopathology
ISSN: 0165-2427
NlmUniqueID: 8002006
Country: Netherlands
Language: English
Volume: 42
Issue: 1
Pages: 3-60

Researcher Affiliations

Kydd, J
  • Thoroughbred Breeders' Association, Equine Fertility Unit, Mertoun Paddocks, Newmarket, UK.
Antczak, D F
    Allen, W R
      Barbis, D
        Butcher, G
          Davis, W
            Duffus, W P
              Edington, N
                Grünig, G
                  Holmes, M A

                    MeSH Terms

                    • Animals
                    • Antigens, CD / classification
                    • Antigens, CD / immunology
                    • B-Lymphocytes / immunology
                    • Histocompatibility Antigens / classification
                    • Histocompatibility Antigens / immunology
                    • Horses / immunology
                    • International Cooperation
                    • T-Lymphocytes / immunology
                    • Terminology as Topic
                    • United Kingdom

                    Grant Funding

                    • HD-08886 / NICHD NIH HHS
                    • HD-15799 / NICHD NIH HHS

                    Citations

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