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Research in veterinary science2007; 84(1); 1-6; doi: 10.1016/j.rvsc.2007.02.008

Retrospective study of bacterial isolates and their antimicrobial susceptibilities in equine uteri during fertility problems.

Abstract: Bacterial pathogens are a potential cause when a mare fails to conceive to a fertile stallion on a well-managed breeding farm on one or more cycles in the same season. Furthermore, emerging bacterial resistance to commonly used (topical) antibiotics has been demonstrated. In this study, a total of 586 uterine swabs from mares with fertility problems were evaluated and the bacterial isolates were identified and measured for resistance to 10 antibiotics most commonly used during bacterial equine infection. Forty-nine percent of the examined mares were positive at bacteriological investigations. Amongst 347 successful isolations, 31.7% were Streptococcus group C and 18.4% Escherichia (E.) coli, both considered frequently associated with fertility problems. Determination of the antibiotic susceptibility pattern of Streptococcus group C (110 organisms) revealed that only the amoxicillin/clavulanic acid was highly active with 82.7% of the isolates being inhibited. For E. coli, a major number of drugs displayed a high potency.
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Publication Date: 2007-04-16 PubMed ID: 17434193DOI: 10.1016/j.rvsc.2007.02.008Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research is a retrospective study examining the types of bacteria found in horse uteri that have fertility problems, and the level of resistance these bacteria show to different antibiotics.

Research Context

  • This study was conducted in the context of search for potential causes of fertility problems in mares. Specifically, the researchers were interested in understanding if bacterial pathogens could potentially cause a mare to fail to conceive.
  • Another point of concern was the growing resistance of bacterial pathogens to commonly used antibiotics. This is a significant problem in equine health and could have implications for fertility issues.

    • Research Method

    • A total of 586 uterine swabs were analyzed from mares who had fertility issues.
    • The bacterial isolates found in these swabs were identified, and their resistance to 10 commonly used antibiotics was measured. This was done to determine which antibiotics would be effective during bacterial equine infection.

      • Research Findings

      • The study found that 49 percent of the mares tested positive on bacteriological examinations. This means that nearly half of them had bacterial pathogens present in the uterus.
      • Out of 347 successful bacterial isolations, 31.7 percent were Streptococcus group C and 18.4 percent were Escherichia (E.) coli. These two types of bacteria are often associated with fertility problems.
      • An analysis of these bacteria’s susceptibility to the antibiotics revealed interesting findings. For the Streptococcus group C, only the combination of amoxicillin and clavulanic acid was highly active, being able to inhibit 82.7 percent of the isolates.
      • For the E. coli strain, a larger number of antibiotics were found to be highly potent and effective.

      Research Implications

      • The results of this study provide crucial insights into the bacterial causes of equine fertility problems and effective strategies for their treatment. The knowledge that certain antibiotics are particularly effective against the more common bacterial causes can help practitioners develop better treatment protocols.
      • The findings also underline the need to regularly monitor the antibiotic susceptibility of bacterial pathogens causing equine fertility problems, due to the growing concern of widespread antibiotic resistance.

Cite This Article

APA
Frontoso R, De Carlo E, Pasolini MP, van der Meulen K, Pagnini U, Iovane G, De Martino L. (2007). Retrospective study of bacterial isolates and their antimicrobial susceptibilities in equine uteri during fertility problems. Res Vet Sci, 84(1), 1-6. https://doi.org/10.1016/j.rvsc.2007.02.008

Publication

Research in veterinary science
ISSN: 0034-5288
NlmUniqueID: 0401300
Country: England
Language: English
Volume: 84
Issue: 1
Pages: 1-6

Researcher Affiliations

Frontoso, R
  • Department of Pathology and Animal Health, Infectious Disease Section, Faculty of Veterinary Medicine, University of Naples Federico II, Via Delpino 1, 80137 Naples, Italy.
De Carlo, E
    Pasolini, M P
      van der Meulen, K
        Pagnini, U
          Iovane, G
            De Martino, L

              MeSH Terms

              • Animals
              • Anti-Bacterial Agents / pharmacology
              • Bacterial Infections / microbiology
              • Bacterial Infections / veterinary
              • Drug Resistance, Bacterial
              • Female
              • Horse Diseases / microbiology
              • Horses
              • Infertility, Female / microbiology
              • Infertility, Female / veterinary
              • Retrospective Studies
              • Uterus / microbiology

              Citations

              This article has been cited 20 times.
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