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Journal of veterinary pharmacology and therapeutics2017; 41(2); 184-194; doi: 10.1111/jvp.12450

Review of triazine antiprotozoal drugs used in veterinary medicine.

Abstract: Triazines are relatively new antiprotozoal drugs that have successfully controlled coccidiosis and equine protozoal myeloencephalitis. These drugs have favorably treated other protozoal diseases such as neosporosis and toxoplasmosis. In this article, we discuss the pharmacological characteristics of five triazines, toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril which are used in veterinary medicine to control protozoal diseases which include coccidiosis, equine protozoal myeloencephalitis, neosporosis, and toxoplasmosis.
© 2017 John Wiley & Sons Ltd.
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Publication Date: 2017-08-17 PubMed ID: 28833212DOI: 10.1111/jvp.12450Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article presents a comprehensive review of triazine antiprotozoal drugs namely, toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril, primarily used in veterinary medicine to treat diseases caused by protozoa such as coccidiosis, equine protozoal myeloencephalitis, neosporosis, and toxoplasmosis.

Introduction to Triazine Antiprotozoal Drugs

  • Triazines as mentioned in the research report are relatively new antiprotozoal drugs. These are chemotherapeutic agents, specifically structured to combat protozoal diseases predominantly in animals.
  • The mentioned triazines include toltrazuril, ponazuril, clazuril, diclazuril, and nitromezuril. These are used extensively in the field of veterinary medicine to control and treat a few specific protozoal diseases.

Diseases Treatable by Triazine Drugs

  • These triazine drugs have proved successful in controlling diseases like coccidiosis, a parasitic disease of the intestinal tract of animals caused by coccidian protozoa.
  • Equine protozoal myeloencephalitis is another serious disease affecting horses, caused by a protozoa that invades the central nervous system, it can also be effectively treated with these drugs.
  • The report notes that veterinary practitioners have recorded favorable outcomes when treating neosporosis, a parasitic disease caused by Neospora caninum, and toxoplasmosis, a parasitic disease caused by Toxoplasma gondii, using triazine antiprotozoal drugs.

Pharmacological Characteristics of Triazine Drugs

  • The research paper conducts a thorough analysis of the pharmacological aspects of the mentioned triazines, digging deeper into their effects, dosages, adverse effects, pharmacokinetic profile, and their mode of action against protozoa.
  • These findings provide essential details to understand the course of treatment and management of the named diseases, which is crucial in making informed decisions regarding treatment methods in veterinary medicine.

In summary, this review provides important insights into the effectiveness and use of triazine antiprotozoal drugs in veterinary medicine. It presents crucial pharmacological details of these drugs and their efficacy against specified protozoal diseases.

Cite This Article

APA
Stock ML, Elazab ST, Hsu WH. (2017). Review of triazine antiprotozoal drugs used in veterinary medicine. J Vet Pharmacol Ther, 41(2), 184-194. https://doi.org/10.1111/jvp.12450

Publication

Journal of veterinary pharmacology and therapeutics
ISSN: 1365-2885
NlmUniqueID: 7910920
Country: England
Language: English
Volume: 41
Issue: 2
Pages: 184-194

Researcher Affiliations

Stock, M L
  • Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Elazab, S T
  • Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
  • Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, El-Mansoura, Egypt.
Hsu, W H
  • Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

MeSH Terms

  • Acetonitriles / therapeutic use
  • Animals
  • Antiprotozoal Agents / therapeutic use
  • Coccidiosis / drug therapy
  • Coccidiosis / veterinary
  • Encephalomyelitis, Equine / drug therapy
  • Encephalomyelitis, Equine / parasitology
  • Encephalomyelitis, Equine / veterinary
  • Horses
  • Nitriles / therapeutic use
  • Protozoan Infections, Animal / drug therapy
  • Toxoplasmosis, Animal / drug therapy
  • Triazines / therapeutic use

Citations

This article has been cited 25 times.
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