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Veterinary journal (London, England : 1997)2014; 203(2); 211-218; doi: 10.1016/j.tvjl.2014.08.033

Rhodococcus equi pneumonia in foals: an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice.

Abstract: Early diagnosis and prevention of Rhodococcus equi pneumonia in foals represent important goals for equine clinicians. Recent protocols for diagnosis and treatment of Rhodococcosis in foals typically rely on a multimodal approach based on sonographic evidence suggestive of pyogranulomas, sonographic abscess scores and laboratory findings including plasma fibrinogen concentrations, blood biochemistry testing and platelet and leukocyte counts. The aim of this study was to assess the utility of weekly testing of serum amyloid A (SAA) and plasma fibrinogen concentrations in foals to achieve early diagnosis of R. equi pneumonia prior to the onset of clinical signs. This testing was used to simulate a clinically practical screening procedure and compared with thoracic ultrasonography performed in parallel. The present study suggests that SAA does not represent a reliable early marker of Rhodococcosis when plasma concentrations are tested weekly. However, when clinical signs of R. equi pneumonia are present, SAA concentrations may allow clinicians to obtain 'real-time' indications concerning both the progress of infection and the effectiveness of therapy. This study raises the possibility that plasma fibrinogen monitoring starting at 1 week of age and repeated on a weekly basis, could serve as a screening test allowing clinicians to identify foals as suspected of R. equi infection. Future investigations regarding both physiological plasma fibrinogen concentrations in foals as well as fibrinogen kinetics in foals affected with R. equi pneumonia, including the establishment of appropriate reference intervals for the test method employed in this study, will be necessary in order to clarify this possibility.
Publication Date: 2014-11-13 PubMed ID: 25555337DOI: 10.1016/j.tvjl.2014.08.033Google Scholar: Lookup
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  • Comparative Study
  • Journal Article

Summary

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The research article discusses a case of Rhodococcus equi pneumonia in a young horse and how it was successfully diagnosed and treated.

Identification and Diagnosis of Rhodococcus equi pneumonia

  • The authors described a case involving a 2-month-old Quarter Horse colt, which exhibited symptoms such as depression, loss of appetite, fever, and moist breathing sounds. These observations prompted further investigation.
  • Diagnosis was completed through various procedures, including thoracic auscultation, which is a clinical examination of the sounds produced by the heart and lungs. The technique helped to identify abnormal breath sounds in the lower sections of the horse’s lungs.
  • Radiography (X-rays) and hematologic examination, a study of the elements of the blood, were used to further substantiate the findings of the auscultation.
  • Moreover, a transtracheal aspiration was utilized to collect a sample from the horse’s respiratory tract; upon inspection, they confirmed the presence of Rhodococcus equi bacteria, implicating it as the causative agent in this case of pneumonia.

Treatment of Rhodococcus equi pneumonia

  • After successful diagnosis, the authors attempted treatment, which proved challenging due to the bacteria’s tendency to create pulmonary abscesses or pus-filled lesions in the lungs. This characteristic can often render some treatment methods ineffective.
  • Before deciding on a treatment protocol, they first performed culture and sensitivity tests on the isolated organisms from the horse’s lungs. These tests are designed to identify the bacteria and determine which antibiotics it is most sensitive or resistant to.
  • Based on the results of these tests, the antibiotics chloramphenicol and erythromycin were initially administered, followed by oral doses of trimethoprim-sulfadiazine, alongside supportive therapy.
  • Following this treatment regimen, the foal was reported to have fully recovered within a two-month period.

Significance and Outcome

  • This paper is an important demonstration of a methodical approach in diagnosing and treating Rhodococcus equi pneumonia, a serious infection in foals. With the help of auscultation, radiography, hematologic examination, transtracheal aspiration, and cultured sensitivity tests, a targeted, effective treatment could be implemented.
  • The full recovery of the horse is a positive outcome, given the challenges associated with treating infections caused by Rhodococcus equi due to its propensity for creating lung abscesses.
  • This case study adds to the broader body of literature about this specific infection in horses, providing clinicians with valuable insights into diagnosis and treatment protocols that can lead to successful outcomes.

Cite This Article

APA
Passamonti F, Vardi DM, Stefanetti V, Marenzoni ML, Prato S, Cévese P, Coletti M, Pepe M, Casagrande Proietti P, Olea-Popelka F. (2014). Rhodococcus equi pneumonia in foals: an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice. Vet J, 203(2), 211-218. https://doi.org/10.1016/j.tvjl.2014.08.033

Publication

ISSN: 1532-2971
NlmUniqueID: 9706281
Country: England
Language: English
Volume: 203
Issue: 2
Pages: 211-218

Researcher Affiliations

Passamonti, F
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy. Electronic address: fabrizio.passamonti@unipg.it.
Vardi, D M
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy.
Stefanetti, V
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy.
Marenzoni, M L
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy.
Prato, S
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy.
Cévese, P
  • Veterinary Clinic, 47 Bigozzi St., Monteriggioni SI 53035, Italy.
Coletti, M
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy.
Pepe, M
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy.
Casagrande Proietti, P
  • Centro di Studio del Cavallo Sportivo, Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, Perugia PG 06126, Italy.
Olea-Popelka, F
  • Department of Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1644, USA.

MeSH Terms

  • Actinomycetales Infections / blood
  • Actinomycetales Infections / microbiology
  • Actinomycetales Infections / veterinary
  • Animals
  • Blood Chemical Analysis / veterinary
  • Fibrinogen / metabolism
  • Horse Diseases / blood
  • Horse Diseases / microbiology
  • Horses
  • Rhodococcus equi / physiology
  • Serum Amyloid A Protein / metabolism
  • Time Factors
  • Ultrasonography / veterinary

Citations

This article has been cited 8 times.
  1. Villalba-Orero M, Gómez CA, Valero-Gónzalez M, Venegas N, Criado G, Martín-Cuervo M. Blood parameters in neonatal foal and colostrum quality as possible early markers for increased risk of developing Rhodococcus equi pneumonia. Front Vet Sci 2025;12:1654052.
    doi: 10.3389/fvets.2025.1654052pubmed: 40948621google scholar: lookup
  2. da Silveira BP, Cohen ND, Lawhon SD, Watson RO, Bordin AI. Protective immune response against Rhodococcus equi: An innate immunity-focused review. Equine Vet J 2025 May;57(3):563-586.
    doi: 10.1111/evj.14214pubmed: 39258739google scholar: lookup
  3. Rakowska A, Czopowicz M, Bereznowski A, Witkowski L. Investigation of the relationship between pulmonary lesions based on lung ultrasound and respiratory clinical signs in foals with suspected pulmonary rhodococcosis. Sci Rep 2023 Nov 8;13(1):19401.
    doi: 10.1038/s41598-023-46833-2pubmed: 37938262google scholar: lookup
  4. Hassanpour A, Moghaddam S. Evaluation of serum concentration of acute-phase proteins (haptoglobin and serum amyloid A) in the affected Arabian foals with rhodococcosis. Vet Med Sci 2023 Jan;9(1):144-149.
    doi: 10.1002/vms3.1005pubmed: 36423204google scholar: lookup
  5. Rakowska A, Cywinska A, Witkowski L. Current Trends in Understanding and Managing Equine Rhodococcosis. Animals (Basel) 2020 Oct 18;10(10).
    doi: 10.3390/ani10101910pubmed: 33081047google scholar: lookup
  6. Long A, Nolen-Walston R. Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A. Vet Clin North Am Equine Pract 2020 Apr;36(1):147-160.
    doi: 10.1016/j.cveq.2019.12.005pubmed: 32007299google scholar: lookup
  7. Witkowska-Piłaszewicz OD, Żmigrodzka M, Winnicka A, Miśkiewicz A, Strzelec K, Cywińska A. Serum amyloid A in equine health and disease. Equine Vet J 2019 May;51(3):293-298.
    doi: 10.1111/evj.13062pubmed: 30565319google scholar: lookup
  8. Giguère S, Berghaus LJ, Miller CD. Clinical Assessment of a Point-of-Care Serum Amyloid A Assay in Foals with Bronchopneumonia. J Vet Intern Med 2016 Jul;30(4):1338-43.
    doi: 10.1111/jvim.13978pubmed: 27296082google scholar: lookup