Animals : an open access journal from MDPI2020; 10(10); 1910; doi: 10.3390/ani10101910

Current Trends in Understanding and Managing Equine Rhodococcosis.

Abstract: The aim of this review was to summarize studies on equine rhodococcosis over the last decade. For many years has remained one of the major health challenges in the equine breeding industry worldwide. Recently, many novel approaches and ideas have been described and some of them were initially implemented into the clinical practice. This study reviews a variety of new information about neonatal susceptibility, clinical appearance, considered and applied diagnostic procedures and treatment alternatives, factors limiting accurate prognosis, ideas regarding environmental management and prophylaxis considerations. Although multiple research were conducted, the main problems such as high morbidity and mortality, a lack of reliable prevention strategies and treatment limitations are still unresolved and require further scientific effort.
Publication Date: 2020-10-18 PubMed ID: 33081047PubMed Central: PMC7603097DOI: 10.3390/ani10101910Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article presents a summary of the major breakthroughs and trends in understanding and managing equine rhodococcosis, an infectious disease that affects horses, over the last ten years. The study encompasses a range of topics including animal susceptibility, diagnostic procedures, treatment alternatives, and preventative measures.

Understanding Neonatal Susceptibility

The researchers have compiled evidence that sheds light on the susceptibility of equine neonates to rhodococcosis. This involves:

  • Identifying the genetic and environmental factors that make them more susceptible to the disease
  • Exploring how their immune system responds to infection

Clinical Appearance

The researchers discuss the complexity of the clinical appearance of rhodococcosis. This includes:

  • Analyzing its symptoms and how they differ from one horse to another
  • Examining the different stages of the disease and how they present clinically

Diagnostic Procedures and Treatment Alternatives

The paper explores the latest diagnostic procedures being considered and applied for rhodococcosis detection. In terms of treatment, a range of alternatives and advancements are outlined:

  • Presenting novel ways of detecting the bacterium that causes rhodococcosis
  • Describing recent advancements in antibiotic therapy and other treatment measures

Prognosis Limitations and Prophylaxis Considerations

The article discusses the difficulties in making accurate predictions about the course and outcome of rhodococcosis in horses. Additionally, the authors delve into potential measures for preventing the disease:

  • Addressing the challenges faced when predicting the progression of the disease
  • Providing updated recommendations and strategies for prevention of rhodococcosis

Unresolved Problems and Future Efforts

Despite considerable progress in understanding and managing equine rhodococcosis, the study highlights persisting issues with high morbidity and mortality, unreliable prevention strategies, and limitations in treatment. As such, researchers argue for:

  • Further research and scientific effort to address these ongoing challenges
  • Emphasizing the need for more effective treatment and prevention strategies for this serious equine disease

Cite This Article

APA
Rakowska A, Cywinska A, Witkowski L. (2020). Current Trends in Understanding and Managing Equine Rhodococcosis. Animals (Basel), 10(10), 1910. https://doi.org/10.3390/ani10101910

Publication

ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 10
Issue: 10
PII: 1910

Researcher Affiliations

Rakowska, Alicja
  • Department of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warszawa, Poland.
Cywinska, Anna
  • Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 1, 02-787 Warszawa, Poland.
Witkowski, Lucjan
  • Department of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-787 Warszawa, Poland.

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 68 references
  1. Giguu00e8re S, Roberts GD. Association between radiographic pattern and outcome in foals with pneumonia caused by Rhodococcus equi.. Vet Radiol Ultrasound 2012 Nov-Dec;53(6):601-4.
  2. Huber L., Gressler L.T., Sanz M.G., Garbade P., Vargas u00c1., Silveira B.P. Monitoring Foals by Thoracic Ultrasonography, Bacterial Culture, and PCR: Diagnostic of Rhodococcus Equi Subclinical Pneumonia in South of Brazil. J. Equine Vet. Sci. 2018;60:104u2013108.e1. doi: 10.1016/j.jevs.2017.08.017.
  3. Treloar S.K., Dhand N.K., Muscatello G. Rhodococcus Equi Pneumonia and Future Racing Performance of the Thoroughbred. J. Equine Vet. Sci. 2012;32:S16u2013S17. doi: 10.1016/j.jevs.2012.08.042.
  4. Giguu00e8re S, Cohen ND, Chaffin MK, Slovis NM, Hondalus MK, Hines SA, Prescott JF. Diagnosis, treatment, control, and prevention of infections caused by Rhodococcus equi in foals.. J Vet Intern Med 2011 Nov-Dec;25(6):1209-20.
  5. Coulson GB, Miranda-CasoLuengo AA, Miranda-CasoLuengo R, Wang X, Oliver J, Willingham-Lane JM, Meijer WG, Hondalus MK. Transcriptome reprogramming by plasmid-encoded transcriptional regulators is required for host niche adaption of a macrophage pathogen.. Infect Immun 2015 Aug;83(8):3137-45.
    doi: 10.1128/IAI.00230-15pmc: PMC4496601pubmed: 26015480google scholar: lookup
  6. Cohen ND, Carter CN, Scott HM, Chaffin MK, Smith JL, Grimm MB, Kuskie KR, Takai S, Martens RJ. Association of soil concentrations of Rhodococcus equi and incidence of pneumonia attributable to Rhodococcus equi in foals on farms in central Kentucky.. Am J Vet Res 2008 Mar;69(3):385-95.
    doi: 10.2460/ajvr.69.3.385pubmed: 18312138google scholar: lookup
  7. Witkowski L. Treatment and prevention of Rhodococcus equi in foals.. Vet Rec 2019 Jul 6;185(1):16-18.
    doi: 10.1136/vr.l4505pubmed: 31273138google scholar: lookup
  8. Hondalus MK, Mosser DM. Survival and replication of Rhodococcus equi in macrophages.. Infect Immun 1994 Oct;62(10):4167-75.
  9. Rofe AP, Davis LJ, Whittingham JL, Latimer-Bowman EC, Wilkinson AJ, Pryor PR. The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis.. Microbiologyopen 2017 Apr;6(2).
    doi: 10.1002/mbo3.416pmc: PMC5387311pubmed: 27762083google scholar: lookup
  10. Chaffin MK, Cohen ND, Martens RJ. Evaluation of equine breeding farm management and preventative health practices as risk factors for development of Rhodococcus equi pneumonia in foals.. J Am Vet Med Assoc 2003 Feb 15;222(4):476-85.
    doi: 10.2460/javma.2003.222.476pubmed: 12597421google scholar: lookup
  11. Vu00e1zquez-Boland JA, Giguu00e8re S, Hapeshi A, MacArthur I, Anastasi E, Valero-Rello A. Rhodococcus equi: the many facets of a pathogenic actinomycete.. Vet Microbiol 2013 Nov 29;167(1-2):9-33.
    doi: 10.1016/j.vetmic.2013.06.016pubmed: 23993705google scholar: lookup
  12. Cohen ND, Chaffin MK, Kuskie KR, Syndergaard MK, Blodgett GP, Takai S. Association of perinatal exposure to airborne Rhodococcus equi with risk of pneumonia caused by R equi in foals.. Am J Vet Res 2013 Jan;74(1):102-9.
    doi: 10.2460/ajvr.74.1.102pubmed: 23270353google scholar: lookup
  13. Sanz M, Loynachan A, Sun L, Oliveira A, Breheny P, Horohov DW. The effect of bacterial dose and foal age at challenge on Rhodococcus equi infection.. Vet Microbiol 2013 Dec 27;167(3-4):623-31.
    doi: 10.1016/j.vetmic.2013.09.018pubmed: 24139178google scholar: lookup
  14. Leclere M, Magdesian KG, Kass PH, Pusterla N, Rhodes DM. Comparison of the clinical, microbiological, radiological and haematological features of foals with pneumonia caused by Rhodococcus equi and other bacteria.. Vet J 2011 Jan;187(1):109-12.
    doi: 10.1016/j.tvjl.2009.10.025pubmed: 19932977google scholar: lookup
  15. Giguu00e8re S, Jordan LM, Glass K, Cohen ND. Relationship of mixed bacterial infection to prognosis in foals with pneumonia caused by Rhodococcus equi.. J Vet Intern Med 2012 Nov-Dec;26(6):1443-8.
  16. McQueen CM, Dindot SV, Foster MJ, Cohen ND. Genetic Susceptibility to Rhodococcus equi.. J Vet Intern Med 2015 Nov-Dec;29(6):1648-59.
    doi: 10.1111/jvim.13616pmc: PMC4895676pubmed: 26340305google scholar: lookup
  17. Whitfield-Cargile CM, Cohen ND, Suchodolski J, Chaffin MK, McQueen CM, Arnold CE, Dowd SE, Blodgett GP. Composition and Diversity of the Fecal Microbiome and Inferred Fecal Metagenome Does Not Predict Subsequent Pneumonia Caused by Rhodococcus equi in Foals.. PLoS One 2015;10(8):e0136586.
  18. Reuss SM, Chaffin MK, Cohen ND. Extrapulmonary disorders associated with Rhodococcus equi infection in foals: 150 cases (1987-2007).. J Am Vet Med Assoc 2009 Oct 1;235(7):855-63.
    doi: 10.2460/javma.235.7.855pubmed: 19793018google scholar: lookup
  19. Tarancu00f3n I, Leiva M, Jose-Cunilleras E, Ru00edos J, Peu00f1a T. Ophthalmologic findings associated with Rhodococcus equi bronchopneumonia in foals.. Vet Ophthalmol 2019 Sep;22(5):660-665.
    doi: 10.1111/vop.12637pubmed: 30706641google scholar: lookup
  20. Reuss SM, Chaffin MK, Schmitz DG, Norman TE. Sonographic characteristics of intraabdominal abscessation and lymphadenopathy attributable to Rhodococcus equi infections in foals.. Vet Radiol Ultrasound 2011 Jul-Aug;52(4):462-5.
  21. Reuss S.M. Extrapulmonary Disorders Associated with Rhodococcus equi Infections. Equine Vet. Educ. 2016;28:193u2013195. doi: 10.1111/eve.12513.
    doi: 10.1111/eve.12513google scholar: lookup
  22. Morresey P.R., Garrett K.S., Carter D. Rhodococcus equi Occipital Bone Osteomyelitis, Septic Arthritis and Meningitis in a Neurological Foal. Equine Vet. Educ. Equine Vet. Educ. 2011;23:398u2013402. doi: 10.1111/j.2042-3292.2010.00119.x.
  23. Hines M.T. In: Rhodococcus equi in Equine Infectious Diseases. 2nd ed. Sellon D.C., Long M.T., editors. Elsevier; St. Louis, MO, USA: 2014. p. 294.
  24. Giguu00e8re S, Prescott JF. Clinical manifestations, diagnosis, treatment, and prevention of Rhodococcus equi infections in foals.. Vet Microbiol 1997 Jun 16;56(3-4):313-34.
    doi: 10.1016/S0378-1135(97)00099-0pubmed: 9226845google scholar: lookup
  25. Bedenice D, Heuwieser W, Brawer R, Solano M, Rand W, Paradis MR. Clinical and prognostic significance of radiographic pattern, distribution, and severity of thoracic radiographic changes in neonatal foals.. J Vet Intern Med 2003 Nov-Dec;17(6):876-86.
  26. Bedenice D, Heuwieser W, Solano M, Rand W, Paradis MR. Risk factors and prognostic variables for survival of foals with radiographic evidence of pulmonary disease.. J Vet Intern Med 2003 Nov-Dec;17(6):868-75.
  27. Giguu00e8re S, Hernandez J, Gaskin J, Miller C, Bowman JL. Evaluation of white blood cell concentration, plasma fibrinogen concentration, and an agar gel immunodiffusion test for early identification of foals with Rhodococcus equi pneumonia.. J Am Vet Med Assoc 2003 Mar 15;222(6):775-81.
    doi: 10.2460/javma.2003.222.775pubmed: 12675301google scholar: lookup
  28. Giguu00e8re S., Cohen N.D. Controversies in Therapy of Infections Caused by Rhodococcus equi in Foals. Equine Vet. Educ. 2018;30:336u2013341. doi: 10.1111/eve.12870.
    doi: 10.1111/eve.12870google scholar: lookup
  29. Arnold-Lehna D, Venner M, Berghaus LJ, Berghaus R, Giguu00e8re S. Changing policy to treat foals with Rhodococcus equi pneumonia in the later course of disease decreases antimicrobial usage without increasing mortality rate.. Equine Vet J 2020 Jul;52(4):531-537.
    doi: 10.1111/evj.13219pubmed: 31808183google scholar: lookup
  30. Wetzig M, Venner M, Giguu00e8re S. Efficacy of the combination of doxycycline and azithromycin for the treatment of foals with mild to moderate bronchopneumonia.. Equine Vet J 2020 Jul;52(4):613-619.
    doi: 10.1111/evj.13211pubmed: 31769897google scholar: lookup
  31. Rantanen N.W. Evaluation of the Respiratory System. Equine Diagnostic Ultrasonography. Williams Wilkins; Baltimore, MD, USA: 1998.
  32. Ramirez S, Lester GD, Roberts GR. Diagnostic contribution of thoracic ultrasonography in 17 foals with Rhodococcus equi pneumonia.. Vet Radiol Ultrasound 2004 Mar-Apr;45(2):172-6.
  33. Hillidge CJ. Use of erythromycin-rifampin combination in treatment of Rhodococcus equi pneumonia.. Vet Microbiol 1987 Aug;14(3):337-42.
    doi: 10.1016/0378-1135(87)90121-0pubmed: 3314109google scholar: lookup
  34. Passamonti F, Vardi DM, Stefanetti V, Marenzoni ML, Prato S, Cu00e9vese P, Coletti M, Pepe M, Casagrande Proietti P, Olea-Popelka F. Rhodococcus equi pneumonia in foals: an assessment of the early diagnostic value of serum amyloid A and plasma fibrinogen concentrations in equine clinical practice.. Vet J 2015 Feb;203(2):211-8.
    doi: 10.1016/j.tvjl.2014.08.033pubmed: 25555337google scholar: lookup
  35. Giguu00e8re S, Berghaus LJ, Miller CD. Clinical Assessment of a Point-of-Care Serum Amyloid A Assay in Foals with Bronchopneumonia.. J Vet Intern Med 2016 Jul;30(4):1338-43.
    doi: 10.1111/jvim.13978pmc: PMC5094540pubmed: 27296082google scholar: lookup
  36. Cohen ND, Chaffin MK, Vandenplas ML, Edwards RF, Nevill M, Moore JN, Martens RJ. Study of serum amyloid A concentrations as a means of achieving early diagnosis of Rhodococcus equi pneumonia.. Equine Vet J 2005 May;37(3):212-6.
    doi: 10.2746/0425164054530704pubmed: 15892228google scholar: lookup
  37. Madrigal RG, Shaw SD, Witkowski LA, Sisson BE, Blodgett GP, Chaffin MK, Cohen ND. Use of Serial Quantitative PCR of the vapA Gene of Rhodococcus equi in Feces for Early Detection of R. equi Pneumonia in Foals.. J Vet Intern Med 2016 Mar-Apr;30(2):664-70.
    doi: 10.1111/jvim.13828pmc: PMC4913589pubmed: 26806422google scholar: lookup
  38. Giguu00e8re S, Hernandez J, Gaskin J, Prescott JF, Takai S, Miller C. Performance of five serological assays for diagnosis of Rhodococcus equi pneumonia in foals.. Clin Diagn Lab Immunol 2003 Mar;10(2):241-5.
  39. Giguu00e8re S., Berghaus L.J., Willingham-Lane J.M. Antimicrobial Resistance in Rhodococcus Equi. Microbiol. Spectr. 2017 doi: 10.1128/microbiolspec.ARBA-0004.
  40. Mercer MA, Davis JL. Clinical insights: Antimicrobials in an age of resistance.. Equine Vet J 2019 Nov;51(6):711-713.
    doi: 10.1111/evj.13151pubmed: 31584724google scholar: lookup
  41. Witkowski L, Rzewuska M, Takai S, Chrobak-Chmiel D, Kizerwetter-u015awida M, Feret M, Gawryu015b M, Witkowski M, Kita J. Molecular characterization of Rhodococcus equi isolates from horses in Poland: pVapA characteristics and plasmid new variant, 85-kb type V.. BMC Vet Res 2017 Jan 26;13(1):35.
    doi: 10.1186/s12917-017-0954-2pmc: PMC5267371pubmed: 28122544google scholar: lookup
  42. Huber L, Giguu00e8re S, Cohen ND, Slovis NM, Hanafi A, Schuckert A, Berghaus L, Greiter M, Hart KA. Prevalence and risk factors associated with emergence of Rhodococcus equi resistance to macrolides and rifampicin in horse-breeding farms in Kentucky, USA.. Vet Microbiol 2019 Aug;235:243-247.
    doi: 10.1016/j.vetmic.2019.07.010pubmed: 31383308google scholar: lookup
  43. Critically Important Antimicrobials for Human Medicine-6th Revision 2018 Ranking of Medically Important Antimicrobials for Risk Management of Antimicrobial Resistance Due to Non-Human Use. [(accessed on 18 October 2020)]; Available online: https://apps.who.int/iris/bitstream/handle/10665/312266/9789241515528-eng.pdf?ua=1.
  44. Venner M, Astheimer K, Lu00e4mmer M, Giguu00e8re S. Efficacy of mass antimicrobial treatment of foals with subclinical pulmonary abscesses associated with Rhodococcus equi.. J Vet Intern Med 2013 Jan-Feb;27(1):171-6.
    doi: 10.1111/jvim.12030pubmed: 23278131google scholar: lookup
  45. Rutenberg D, Venner M, Giguu00e8re S. Efficacy of Tulathromycin for the Treatment of Foals with Mild to Moderate Bronchopneumonia.. J Vet Intern Med 2017 May;31(3):901-906.
    doi: 10.1111/jvim.14717pmc: PMC5435035pubmed: 28421633google scholar: lookup
  46. Hildebrand F, Venner M, Giguu00e8re S. Efficacy of gamithromycin for the treatment of foals with mild to moderate bronchopneumonia.. J Vet Intern Med 2015 Jan;29(1):333-8.
    doi: 10.1111/jvim.12504pmc: PMC4858060pubmed: 25619521google scholar: lookup
  47. Cauchard S, Giguu00e8re S, Venner M, Muscatello G, Cauchard J, Cohen ND, Haas A, Hines SA, Hondalus MK, Horohov DW, Meijer WG, Prescott JF, Vu00e1zquez-Boland J. Rhodococcus equi research 2008-2012: report of the Fifth International Havemeyer Workshop.. Equine Vet J 2013 Sep;45(5):523-6.
    doi: 10.1111/evj.12103pubmed: 23909447google scholar: lookup
  48. Berghaus LJ, Giguu00e8re S, Guldbech K. Mutant prevention concentration and mutant selection window for 10 antimicrobial agents against Rhodococcus equi.. Vet Microbiol 2013 Oct 25;166(3-4):670-5.
    doi: 10.1016/j.vetmic.2013.07.006pubmed: 23915992google scholar: lookup
  49. Cohen ND, Giguu00e8re S, Burton AJ, Rocha JN, Berghaus LJ, Brake CN, Bordin AI, Coleman MC. Use of Liposomal Gentamicin for Treatment of 5 Foals with Experimentally Induced Rhodococcus equi Pneumonia.. J Vet Intern Med 2016 Jan-Feb;30(1):322-5.
    doi: 10.1111/jvim.13810pmc: PMC4913631pubmed: 26692327google scholar: lookup
  50. Cohen ND, Slovis NM, Giguu00e8re S, Baker S, Chaffin MK, Bernstein LR. Gallium maltolate as an alternative to macrolides for treatment of presumed Rhodococcus equi pneumonia in foals.. J Vet Intern Med 2015 May-Jun;29(3):932-9.
    doi: 10.1111/jvim.12595pmc: PMC4895420pubmed: 25868480google scholar: lookup
  51. McCracken J.L., Slovis N.M., Acvim D. Use of Thoracic Ultrasound for the Prevention of Rhodococcus equi Pneumonia on Endemic Farms. Proc. Am. Assoc. Equine Pract. 2009;55:38u201344.
  52. Chaffin MK, Cohen ND, Martens RJ. Chemoprophylactic effects of azithromycin against Rhodococcus equi-induced pneumonia among foals at equine breeding farms with endemic infections.. J Am Vet Med Assoc 2008 Apr 1;232(7):1035-47.
    doi: 10.2460/javma.232.7.1035pubmed: 18380623google scholar: lookup
  53. Huber L, Giguu00e8re S, Slovis NM, Carter CN, Barr BS, Cohen ND, Elam J, Erol E, Locke SJ, Phillips ED, Smith JL. Emergence of Resistance to Macrolides and Rifampin in Clinical Isolates of Rhodococcus equi from Foals in Central Kentucky, 1995 to 2017.. Antimicrob Agents Chemother 2019 Jan;63(1).
    doi: 10.1128/AAC.01714-18pmc: PMC6325176pubmed: 30373803google scholar: lookup
  54. Burton AJ, Giguu00e8re S, Sturgill TL, Berghaus LJ, Slovis NM, Whitman JL, Levering C, Kuskie KR, Cohen ND. Macrolide- and rifampin-resistant Rhodococcus equi on a horse breeding farm, Kentucky, USA.. Emerg Infect Dis 2013 Feb;19(2):282-5.
    doi: 10.3201/eid1902.121210pmc: PMC3559061pubmed: 23347878google scholar: lookup
  55. Giguu00e8re S, Jacks S, Roberts GD, Hernandez J, Long MT, Ellis C. Retrospective comparison of azithromycin, clarithromycin, and erythromycin for the treatment of foals with Rhodococcus equi pneumonia.. J Vet Intern Med 2004 Jul-Aug;18(4):568-73.
  56. Venner M, Reinhold B, Beyerbach M, Feige K. Efficacy of azithromycin in preventing pulmonary abscesses in foals.. Vet J 2009 Feb;179(2):301-3.
    doi: 10.1016/j.tvjl.2007.10.002pubmed: 18023599google scholar: lookup
  57. Kahn SK, Blodgett GP, Canaday NM, Bevevino KE, Rocha JN, Bordin AI, Cohen ND. Transfusion With 2u00a0L of Hyperimmune Plasma is Superior to Transfusion of 1u00a0L or Less for Protecting Foals Against Subclinical Pneumonia Attributed to Rhodococcus equi.. J Equine Vet Sci 2019 Aug;79:54-58.
    doi: 10.1016/j.jevs.2019.05.015pubmed: 31405501google scholar: lookup
  58. Swerczek T.W. Pathogenesis, Treatment, and Control of Streptococcus Equi Infection (Strangles) in Horses; Proceedings of the First Annual Eastern States Veterinary Conference; Orland, FL, USA. 18 January 1984.
  59. Walter Swerczek T. Exacerbation of Streptococcus Equi (Strangles) by Overly Nutritious Diets in Horses: A Model for Infectious Bacterial Diseases of Horses and Other Livestock. Anim. Vet. Sci. 2019;7:18. doi: 10.11648/j.avs.20190701.13.
  60. Huber L, Giguu00e8re S, Berghaus LJ, Hanafi A, Ryan C. Fecal shedding of Rhodococcus equi in mares and foals after experimental infection of foals and effect of composting on concentrations of R. equi in contaminated bedding.. Vet Microbiol 2018 Sep;223:42-46.
    doi: 10.1016/j.vetmic.2018.07.017pubmed: 30173750google scholar: lookup
  61. Ward AL, Reddyvari P, Borisova R, Shilabin AG, Lampson BC. An inhibitory compound produced by a soil isolate of Rhodococcus has strong activity against the veterinary pathogen R. equi.. PLoS One 2018;13(12):e0209275.
  62. Rocha JN, Cohen ND, Bordin AI, Brake CN, Giguu00e8re S, Coleman MC, Alaniz RC, Lawhon SD, Mwangi W, Pillai SD. Oral Administration of Electron-Beam Inactivated Rhodococcus equi Failed to Protect Foals against Intrabronchial Infection with Live, Virulent R. equi.. PLoS One 2016;11(2):e0148111.
  63. Perkins GA, Wagner B. The development of equine immunity: Current knowledge on immunology in the young horse.. Equine Vet J 2015 May;47(3):267-74.
    doi: 10.1111/evj.12387pubmed: 25405920google scholar: lookup
  64. Sanz MG, Loynachan A, Horohov DW. Rhodococcus equi hyperimmune plasma decreases pneumonia severity after a randomised experimental challenge of neonatal foals.. Vet Rec 2016 Mar 12;178(11):261.
    doi: 10.1136/vr.103095pubmed: 26932206google scholar: lookup
  65. Erganis O, Sayin Z, Hadimli HH, Sakmanoglu A, Pinarkara Y, Ozdemir O, Maden M. The effectiveness of anti-R. equi hyperimmune plasma against R. equi challenge in thoroughbred Arabian foals of mares vaccinated with R. equi vaccine.. ScientificWorldJournal 2014;2014:480732.
    doi: 10.1155/2014/480732pmc: PMC3997159pubmed: 24982958google scholar: lookup
  66. Witkowski L, Kaba J, Rzewuska M, Nowicki M, Szaluu015b-Jordanow O, Kita J. Development of ELISA test for determination of the level of antibodies against Rhodococcus equi in equine serum and colostrum.. Vet Immunol Immunopathol 2012 Oct 15;149(3-4):280-5.
    doi: 10.1016/j.vetimm.2012.07.009pubmed: 22883938google scholar: lookup
  67. Bordin AI, Pillai SD, Brake C, Bagley KB, Bourquin JR, Coleman M, Oliveira FN, Mwangi W, McMurray DN, Love CC, Felippe MJ, Cohen ND. Immunogenicity of an electron beam inactivated Rhodococcus equi vaccine in neonatal foals.. PLoS One 2014;9(8):e105367.
  68. Cywes-Bentley C, Rocha JN, Bordin AI, Vinacur M, Rehman S, Zaidi TS, Meyer M, Anthony S, Lambert M, Vlock DR, Giguu00e8re S, Cohen ND, Pier GB. Antibody to Poly-N-acetyl glucosamine provides protection against intracellular pathogens: Mechanism of action and validation in horse foals challenged with Rhodococcus equi.. PLoS Pathog 2018 Jul;14(7):e1007160.

Citations

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  1. Knox A, Zerna G, Beddoe T. Current and Future Advances in the Detection and Surveillance of Biosecurity-Relevant Equine Bacterial Diseases Using Loop-Mediated Isothermal Amplification (LAMP).. Animals (Basel) 2023 Aug 18;13(16).
    doi: 10.3390/ani13162663pubmed: 37627456google scholar: lookup
  2. Sting R, Schwabe I, Kieferle M, Mu00fcnch M, Rau J. Fatal Infection in an Alpaca (Vicugna pacos) Caused by Pathogenic Rhodococcus equi.. Animals (Basel) 2022 May 19;12(10).
    doi: 10.3390/ani12101303pubmed: 35625149google scholar: lookup
  3. Nielsen SS, Bicout DJ, Calistri P, Canali E, Drewe JA, Garin-Bastuji B, Gonzales Rojas JL, Gortu00e1zar C, Herskin M, Michel V, Miranda Chueca Mu00c1, Padalino B, Pasquali P, Roberts HC, Spoolder H, Stu00e5hl K, Velarde A, Viltrop A, Winckler C, Baldinelli F, Broglia A, Kohnle L, Alvarez J. Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Rhodococcus equi in horses.. EFSA J 2022 Feb;20(2):e07081.
    doi: 10.2903/j.efsa.2022.7081pubmed: 35136423google scholar: lookup
  4. Kahn SK, Cywes-Bentley C, Blodgett GP, Canaday NM, Turner-Garcia CE, Flores-Ahlschwede P, Metcalfe LL, Nevill M, Vinacur M, Sutter PJ, Meyer SC, Bordin AI, Pier GB, Cohen ND. Randomized, controlled trial comparing Rhodococcus equi and poly-N-acetyl glucosamine hyperimmune plasma to prevent Ru2009equi pneumonia in foals.. J Vet Intern Med 2021 Nov;35(6):2912-2919.
    doi: 10.1111/jvim.16294pubmed: 34738651google scholar: lookup
  5. u017bychska M, Witkowski L, Klementowska A, Rzewuska M, Kwiecieu0144 E, Stefau0144ska I, Czopowicz M, Szaluu015b-Jordanow O, Mickiewicz M, Moroz A, Bonecka J, Kaba J. Rhodococcus equi-Occurrence in Goats and Clinical Case Report.. Pathogens 2021 Sep 4;10(9).
    doi: 10.3390/pathogens10091141pubmed: 34578172google scholar: lookup