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Journal of the American Veterinary Medical Association2013; 242(9); 1267-1270; doi: 10.2460/javma.242.9.1267

Risk factors associated with nasopharyngeal cicatrix syndrome in horses.

Abstract: To determine risk factors associated with the development of nasopharyngeal cicatrix syndrome (NCS) in horses. Methods: Retrospective case-control study. Methods: 242 horses referred for endoscopic evaluation of the upper portion of the respiratory tract (121 horses with NCS and 121 control horses). Methods: Medical records of horses that had an endoscopic evaluation of the upper airway performed between January 2003 and December 2008 were reviewed. Signalment, housing management, and season of evaluation were recorded and reviewed for each horse. The associations between clinical signs and endoscopic findings were evaluated by the use of a prospective logistic model that included a Bayesian method for inference. Results-Breed and sex had no significant effect on the risk of having NCS. The risk that a horse had NCS increased significantly with age. Exclusive housing in a stall was protective against the development of NCS. In addition, the amount of pasture turnout had a dose-related effect, with exclusive pasture turnout positively correlated with increased risk of developing NCS, compared with a mixture of pasture turnout and stall confinement. Horses were significantly more likely to be evaluated because of clinical signs of the syndrome during the warm months of the year. Conclusions: The risk factors for NCS identified in this study may support chronic environmental exposure to an irritant or infectious agent as the cause of NCS. Information gained from this study should be useful for investigating the cause of NCS.
Publication Date: 2013-04-23 PubMed ID: 23600785DOI: 10.2460/javma.242.9.1267Google Scholar: Lookup
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  • Journal Article

Summary

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This research article discusses an investigation into the risk factors associated with the development of nasopharyngeal cicatrix syndrome (NCS) in horses, revealing that age and housing conditions can significantly impact the prevalence of the condition, while breed and sex appear to hold no significant effect.

Introduction to the Study

  • The research was designed as a retrospective case-control study involving 242 horses, all of which had undergone endoscopic evaluation for respiratory tract conditions. The study group was equally divided into 121 horses with NCS, and 121 control horses without NCS.
  • The evaluation of medical records spanning from January 2003 to December 2008 was carried out to gather necessary data for the research. Each horse’s medical history, housing management, and season of evaluation were all taken into account.
  • The potential associations between clinical manifestations and endoscopic findings were analyzed using a sophisticated prospective logistic model, which included a Bayesian method for inference – a statistical approach that combines prior data with current data to make deductions.

Research Findings

  • The researchers found no significant correlation between the horse’s breed or sex and the risk of developing NCS.
  • Age was established as a significant risk factor, with the likelihood of NCS increasing as horses grew older.
  • Interestingly, housing conditions heavily impacted the likelihood of NCS development. Horses exclusively kept in stalls were less likely to develop NCS, suggesting that stall confinement is protective against the syndrome.
  • Contrarily, the risk of NCS development was found to have a dose-related effect with the amount of pasture turnout, concluding that continuous exposure to the pasture increased NCS likelihood. This finding indicates a potential environmental influence on the onset of NCS.
  • The study also revealed a seasonal pattern, with horses being more likely to show clinical signs of NCS during the warmer months.

Conclusions

  • The identified risk factors suggest that chronic environmental exposure to certain irritants or infectious agents might play a role in causing NCS.
  • The information gained from this study would provide a useful foundation for further investigations on the exact cause of NCS and how to counteract this condition in the horse population.

Cite This Article

APA
Norman TE, Chaffin MK, Bissett WT, Thompson JA. (2013). Risk factors associated with nasopharyngeal cicatrix syndrome in horses. J Am Vet Med Assoc, 242(9), 1267-1270. https://doi.org/10.2460/javma.242.9.1267

Publication

ISSN: 1943-569X
NlmUniqueID: 7503067
Country: United States
Language: English
Volume: 242
Issue: 9
Pages: 1267-1270

Researcher Affiliations

Norman, Tracy E
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine and Biological Sciences, Texas A&M University, College Station, TX 77843, USA. tnorman@cvm.tamu.edu
Chaffin, M Keith
    Bissett, Wesley T
      Thompson, James A

        MeSH Terms

        • Animals
        • Case-Control Studies
        • Cicatrix / etiology
        • Cicatrix / pathology
        • Cicatrix / veterinary
        • Horse Diseases / etiology
        • Horse Diseases / pathology
        • Horses
        • Nasopharyngeal Diseases / complications
        • Nasopharyngeal Diseases / pathology
        • Nasopharyngeal Diseases / veterinary
        • Odds Ratio
        • Retrospective Studies
        • Risk Factors
        • Seasons

        Citations

        This article has been cited 3 times.
        1. Rodríguez N, Whitfield-Cargile CM, Chamoun-Emanuelli AM, Hildreth E, Jordan W, Coleman MC. Nasopharyngeal bacterial and fungal microbiota in normal horses and horses with nasopharyngeal cicatrix syndrome. J Vet Intern Med 2021 Nov;35(6):2897-2911.
          doi: 10.1111/jvim.16307pubmed: 34783081google scholar: lookup
        2. Vail KJ, Stranahan LW, Richardson LM, Yanchik AE, Arnold CE, Porter BF, Wiener DJ. Granulomatous Rhinitis in a Horse due to Mycobacterium intracellulare Infection. J Comp Pathol 2019 May;169:30-34.
          doi: 10.1016/j.jcpa.2019.04.001pubmed: 31159948google scholar: lookup
        3. Kane-Smyth J, Barnett TP, Mark O'Leary J, Dixon PM. Surgical Treatment of Iatrogenic Ventral Glottic Stenosis Using a Mucosal Flap Technique. Vet Surg 2016 May;45(4):436-42.
          doi: 10.1111/vsu.12465pubmed: 27013024google scholar: lookup