Role of homocysteine metabolism in animal reproduction: A review.
Abstract: Homocysteine (Hcy) is a thiol-containing essential amino acid, important for the growth of cells and tissues. Several hypotheses exist regarding Hcy toxicity in humans; Hcy is involved in protein structural modifications, oxidative stress, and neurotoxicity induction and is therefore associated with several pathological conditions in humans. In veterinary science, knowledge regarding Hcy has increased recently due to several studies; however, many aspects remain undiscovered. Many details remain unknown regarding the effect of Hcy levels on pregnancy and the optimal management of pathological conditions associated with Hcy levels during pregnancy in various species. In this review, we aimed to compile various studies on Hcy metabolism to elucidate its current status in the veterinary field, particularly for ovine, bovine, equine, porcine, canine, and feline species.
Copyright © 2018 Elsevier Ltd. All rights reserved.
Publication Date: 2018-11-12 PubMed ID: 30448392DOI: 10.1016/j.rvsc.2018.11.011Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Review
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article is a review of homocysteine (Hcy)’s role in animal reproduction, its relation to certain pathological conditions, and how its levels affect pregnancy in various animal species.
Background on Homocysteine
- Homocysteine (Hcy) is an essential amino acid with a thiol group, crucial for the growth of cells and tissues.
- Though its negative impact on human health is well-researched and understood, including its involvement in protein structural modifications, oxidative stress, and neurotoxicity induction, Hcy’s role in animal health and reproduction is less explored.
Homocysteine in Veterinary Science
- In veterinary science, recent studies have started to shed light on the importance and role of Hcy, but there is still much to learn.
- Hcy’s impact on pregnancy and the management of pathological conditions associated with Hcy during animal pregnancies remain mostly unknown.
Aims of the Review
- The review aims to compile and present the current knowledge about Hcy metabolism in the context of veterinary science from various studies.
- The focus is primarily on ovine (sheep), bovine (cattle), equine (horses), porcine (pigs), canine (dogs), and feline (cats) species.
Implications and Future Research
- This review can provide a comprehensive baseline for future research aiming to better understand the role and impact of Hcy in the reproductive and overall health of various animal species.
- Additionally, the insights gained could potentially provide novel approaches for the optimal management of conditions associated with Hcy levels during animal pregnancies.
Cite This Article
APA
Rizzo A, Sciorsci RL.
(2018).
Role of homocysteine metabolism in animal reproduction: A review.
Res Vet Sci, 122, 29-35.
https://doi.org/10.1016/j.rvsc.2018.11.011 Publication
Researcher Affiliations
- Department of Veterinary Medicine, Section of Obstetric Clinic, University of Bari Aldo Moro, S.P. per Casamassima km 3, 70010 Valenzano, BA, Italy.
- Department of Veterinary Medicine, Section of Obstetric Clinic, University of Bari Aldo Moro, S.P. per Casamassima km 3, 70010 Valenzano, BA, Italy. Electronic address: raffaeleluigi.sciorsci@uniba.it.
MeSH Terms
- Animals
- Female
- Homocysteine / metabolism
- Oxidative Stress
- Pregnancy
- Pregnancy, Animal / physiology
Citations
This article has been cited 5 times.- Ijab R, Ayen E, Khaki A, Soleimanzadeh A. Evaluation of dietary betaine on post-thawed semen quality in mature bulls during summer heat stress.. Vet Res Forum 2022 Mar;13(1):61-70.
- Dos Santos DP, Ribeiro DF, Frigoli GF, Erthal RP, da Silva Scarton SR, de Lion Siervo GEM, Seiva FRF, Staurengo-Ferrari L, Verri WA Jr, Deminice R, Fernandes GSA. Voluntary Exercise Attenuates Hyperhomocysteinemia, But Does not Protect Against Hyperhomocysteinemia-Induced Testicular and Epididymal Disturbances.. Reprod Sci 2022 Jan;29(1):277-290.
- El-Sheikh M, Mesalam AA, Song SH, Ko J, Kong IK. Melatonin Alleviates the Toxicity of High Nicotinamide Concentrations in Oocytes: Potential Interaction with Nicotinamide Methylation Signaling.. Oxid Med Cell Longev 2021;2021:5573357.
- Cordaro M, Siracusa R, Fusco R, Cuzzocrea S, Di Paola R, Impellizzeri D. Involvements of Hyperhomocysteinemia in Neurological Disorders.. Metabolites 2021 Jan 6;11(1).
- Rehman T, Shabbir MA, Inam-Ur-Raheem M, Manzoor MF, Ahmad N, Liu ZW, Ahmad MH, Siddeeg A, Abid M, Aadil RM. Cysteine and homocysteine as biomarker of various diseases.. Food Sci Nutr 2020 Sep;8(9):4696-4707.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
