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Home / Equine Research Bank / Anim Reprod Sci / Role of Sertoli cell number and function on regulation of sp...
Animal reproduction science2007; 105(1-2); 23-51; doi: 10.1016/j.anireprosci.2007.11.029

Role of Sertoli cell number and function on regulation of spermatogenesis.

Abstract: Testicular function is under the control of expression and repression of several genes and gene products, and many of these works through Sertoli cells. The capability of Sertoli cells to regulate spermatogenesis is dependent on Sertoli cell functions and Sertoli cell number. Sertoli cell number has long been thought to be stable in adults with no proliferation of Sertoli cells once adult numbers have been reached. However, adult horses do not have stable Sertoli cell numbers, and new studies indicate that adult Sertoli cells can be made to re-enter mitotic phase under certain experimental conditions. This review discusses roles of Sertoli cells in regulation of spermatogenesis and methods for estimating the number of Sertoli cells, in a testis, that overcome the problems (assumptions) associated with the indented, pear-shaped of Sertoli cell nuclei which make it difficult to estimate the volume of individual nuclei. Using several approaches to overcome the problems associated with any one method, the horse is identified as a species in which Sertoli cell number is not fixed, but it fluctuates with season. In addition to Sertoli cell numbers, the functions of Sertoli cells that are very important in signaling and controlling spermatogenesis are discussed. Recent studies have shown that "post-mitotic terminally differentiated Sertoli cells" from adult animals could, under certain conditions, re-enter the cell division cycle. Can seasonal influences be a natural set of conditions to induce the Sertoli cells of the horse testis to seasonally re-enter the cell division cycle and explain the seasonal differences in Sertoli cell number as summarized in this review? Alternatively, can seasonal differences in Sertoli cell number reflect, in the horse to a greater extent, but in adults of most species, the presence of some mitotic-capable Sertoli cells in adults? In any case, both Sertoli cell number and function are important in regulation of spermatogenesis.
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Publication Date: 2007-12-15 PubMed ID: 18242891DOI: 10.1016/j.anireprosci.2007.11.029Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • N.I.H.
  • Extramural
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.
  • Review

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on the role of Sertoli cells in regulating spermatogenesis, the process of sperm production. It challenges the traditionally accepted belief that the number of Sertoli cells are stable in adult mammals, pointing to evidence that Sertoli cells can reenter the mitotic phase and multiply, particularly in horses where such cell numbers fluctuate seasonally.

The Role of Sertoli Cells in Spermatogenesis

  • The study delves into the crucial role played by Sertoli cells in controlling testicular function. Sertoli cells help regulate the reproduction and expression of several genes and gene products that are vital for testicular function.
  • Dependent largely on their number and functionality, Sertoli cells regulate spermatogenesis, the process in which sperm cells are produced and developed.

Re-assessing Sertoli Cell Numbers

  • The study calls into question the long-held belief that Sertoli cell numbers in adults are stable, not proliferating once mature quantities have been reached.
  • Citing evidence from the study of adult horses, it suggests the possibility that Sertoli cell numbers are not fixed but fluctuate with the seasons. The study indicates that adult Sertoli cells can re-enter the mitotic phase to divide and multiply under specific experimental conditions.
  • This poses potential implications for further research, indicating that such findings may apply not just in horses but in many adult species where previously it was thought that Sertoli cells’ proliferation capability was lost after reaching adulthood.

Estimating Sertoli Cell Numbers

  • The study also touches on the challenges associated with estimating the number of Sertoli cells within a testis. This hurdle arises due to the indented, pear-shaped nature of Sertoli cell nuclei that makes it difficult to accurately estimate the volume of individual nuclei.
  • However, the researchers used several methods to surmount this problem, emphasizing the importance of a multi-faceted approach to accurately evaluate Sertoli cell numbers.

The Function of Sertoli Cells

  • In addition to cell numbers, the research also brings focus to the functions of Sertoli cells that play a crucial role in signaling and controlling spermatogenesis. The study suggests that under certain conditions, even terminally differentiated Sertoli cells from adult animals, previously thought to be post-mitotic, could re-enter the cell division cycle.
  • This revelation has the potential to drastically alter our understanding of cell cycle control and cell differentiation, suggesting that circumstances might exist which could persuade differentiated cells to re-enter the cell division cycle once again.

Cite This Article

APA
Johnson L, Thompson DL, Varner DD. (2007). Role of Sertoli cell number and function on regulation of spermatogenesis. Anim Reprod Sci, 105(1-2), 23-51. https://doi.org/10.1016/j.anireprosci.2007.11.029

Publication

Animal reproduction science
ISSN: 0378-4320
NlmUniqueID: 7807205
Country: Netherlands
Language: English
Volume: 105
Issue: 1-2
Pages: 23-51

Researcher Affiliations

Johnson, Larry
  • Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&M University, College Station, TX 77843-4458, USA. ljohnson@cvm.tamu.edu
Thompson, Donald L
    Varner, Dickson D

      MeSH Terms

      • Animals
      • Cell Count
      • Cell Proliferation
      • Humans
      • Male
      • Seasons
      • Seminiferous Tubules / cytology
      • Seminiferous Tubules / ultrastructure
      • Sertoli Cells / cytology
      • Sertoli Cells / physiology
      • Spermatogenesis / physiology
      • Spermatozoa / physiology

      Grant Funding

      • R25 ES 10735 / NIEHS NIH HHS
      • R25 RR022711 / NCRR NIH HHS

      Citations

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