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EFSA journal. European Food Safety Authority2022; 20(3); e07158; doi: 10.2903/j.efsa.2022.7158

Safety and efficacy of a feed additive consisting of an extract of olibanum from Boswellia serrata Roxb. ex Colebr. for use in dogs and horses (FEFANA asbl).

Abstract: Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of olibanum extract from Roxb. ex Colebr., when used as a sensory additive (flavouring) in feed for all dogs and horses. The FEEDAP Panel concluded that the additive under assessment is safe for horses at the maximum proposed use level of 100 mg/kg in complete feed. For dogs, the calculated safe concentration in feed is 330 mg/kg complete feed. The additive is considered safe for consumers when used at the proposed conditions of use in horses. The additive under assessment should be considered as non-irritant to skin and eyes, but in the absence of data, no conclusion can be drawn on its potential to be a dermal and respiratory sensitiser. The use of the additive under the proposed conditions of use in feed for horses was not expected to pose a risk for the environment. species and their preparations were recognised to flavour food. Since their function in feed would be essentially the same as that in food, no further demonstration of efficacy was considered necessary.
© 2022 Wiley‐VCH Verlag GmbH & Co. KgaA on behalf of the European Food Safety Authority.
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Publication Date: 2022-03-07 PubMed ID: 35281639PubMed Central: PMC8900119DOI: 10.2903/j.efsa.2022.7158Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research examines the safety and effectiveness of using an extract of olibanum from the Boswellia serrata plant as a flavor enhancer in animal feed, specifically for dogs and horses. It was concluded that the extract is safe for these animals, as well as consumers of these animals, and does not pose environmental risks.

Study Purpose and Request

  • The European Commission requested the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) to provide a scientific opinion on the safety and efficacy of olibanum extract from Boswellia serrata Roxb. ex Colebr.
  • This extract was evaluated as a sensory additive (flavouring) in feed for all dogs and horses.

Safety Assessment

  • The FEEDAP Panel determined the additive of olibanum extract to be safe for horses at the maximum proposed use level of 100 mg/kg in complete feed.
  • For dogs, the safe concentration in feed was calculated at 330 mg/kg complete feed.
  • It was determined the additive is considered safe for consumers when used at the proposed conditions of use in horses.
  • The additive was evaluated for its irritant properties to skin and eyes, and it was concluded that it does not cause irritation.
  • However, the panel could not draw a conclusion on whether the extract could cause dermal and respiratory sensitisation due to the lack of data.

Environmental Impact

  • The Panel assessed the potential environmental impact of using the olibanum extract as an additive in horse feed.
  • They found that its usage under the proposed conditions was not expected to pose a risk for the environment.

Function and Efficacy

  • Species from Boswellia serrata and their preparations were recognised to flavor food.
  • The Panel agreed that the function of this extract in animal feed would be essentially the same as that in food.
  • Given this similarity of function, the Panel concluded that no further demonstration of efficacy was needed in terms of enhancing the flavor of animal feed.

Cite This Article

APA
Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Edoardo Villa R, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. (2022). Safety and efficacy of a feed additive consisting of an extract of olibanum from Boswellia serrata Roxb. ex Colebr. for use in dogs and horses (FEFANA asbl). EFSA J, 20(3), e07158. https://doi.org/10.2903/j.efsa.2022.7158

Publication

EFSA journal. European Food Safety Authority
ISSN: 1831-4732
NlmUniqueID: 101642076
Country: United States
Language: English
Volume: 20
Issue: 3
Pages: e07158
PII: e07158

Researcher Affiliations

Bampidis, Vasileios
    Azimonti, Giovanna
      Bastos, Maria de Lourdes
        Christensen, Henrik
          Fašmon Durjava, Mojca
            Kouba, Maryline
              López-Alonso, Marta
                López Puente, Secundino
                  Marcon, Francesca
                    Mayo, Baltasar
                      Pechová, Alena
                        Petkova, Mariana
                          Ramos, Fernando
                            Sanz, Yolanda
                              Edoardo Villa, Roberto
                                Woutersen, Ruud
                                  Brantom, Paul
                                    Chesson, Andrew
                                      Westendorf, Johannes
                                        Manini, Paola
                                          Pizzo, Fabiola
                                            Dusemund, Birgit

                                              References

                                              This article includes 50 references
                                              1. Abdel-Tawab M, Werz O, Schubert-Zsilavecz M. Boswellia serrata: an overall assessment of in vitro, preclinical, pharmacokinetic and clinical data.. Clin Pharmacokinet 2011 Jun;50(6):349-69.
                                                pubmed: 21553931doi: 10.2165/11586800-000000000-00000google scholar: lookup
                                              2. Alluri VK, Dodda S, Kilari EK, Golakoti T, Sengupta K. Toxicological Assessment of a Standardized Boswellia serrata Gum Resin Extract.. Int J Toxicol 2019 Sep Oct;38(5):423-435.
                                                pubmed: 31234670doi: 10.1177/1091581819858069google scholar: lookup
                                              3. Anthony A, Caldwell J, Hutt AJ, Smith RL. Metabolism of estragole in rat and mouse and influence of dose size on excretion of the proximate carcinogen 1'-hydroxyestragole.. Food Chem Toxicol 1987 Nov;25(11):799-806.
                                                pubmed: 3121480doi: 10.1016/0278-6915(87)90257-2google scholar: lookup
                                              4. van den Berg SJPL, Restani P, Boersma MG, Delmulle L, Rietjens IMCM. Levels of genotoxic and carcinogenic compounds in plant food supplements and associated risk assessment.. Food and Nutrition Sciences 2011;2:989–1010.
                                              5. Boden SE, Schweizer S, Bertsche T, Düfer M, Drews G, Safayhi H. Stimulation of leukotriene synthesis in intact polymorphonuclear cells by the 5-lipoxygenase inhibitor 3-oxo-tirucallic acid.. Mol Pharmacol 2001 Aug;60(2):267-73.
                                                pubmed: 11455013doi: 10.1124/mol.60.2.267google scholar: lookup
                                              6. Burdock GA. Fenaroli’s Handbook of Flavor Ingredients 6th Edition. 2009.
                                              7. EFSA (European Food Safety Authority). Compendium of botanicals reported to contain naturally occurring substances of possible concern for human health when used in food and food supplements.. EFSA Journal 2012;10(5):2663, 60 pp.
                                                doi: 10.2903/j.efsa.2012.2663google scholar: lookup
                                              8. EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed). Guidance for the preparation of dossiers for sensory additives.. EFSA Journal 2012;10(1):2534, 26 pp.
                                                doi: 10.2903/j.efsa.2012.2534google scholar: lookup
                                              9. EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed). Guidance on studies concerning the safety of use of the additive for users/workers.. EFSA Journal 2012;10(1):2539, 5 pp.
                                                doi: 10.2903/j.efsa.2012.2539google scholar: lookup
                                              10. Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Gropp J, Kolar B, Kouba M, López-Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Anguita M, Galobart J, Innocenti ML. Guidance on the identity, characterisation and conditions of use of feed additives.. EFSA J 2017 Oct;15(10):e05023.
                                                doi: 10.2903/j.efsa.2017.5023pmc: PMC7010039pubmed: 32625313google scholar: lookup
                                              11. Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Gropp J, Kolar B, Kouba M, López-Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Anguita M, Galobart J, Innocenti ML, Martino L. Guidance on the assessment of the safety of feed additives for the target species.. EFSA J 2017 Oct;15(10):e05021.
                                                doi: 10.2903/j.efsa.2017.5021pmc: PMC7009839pubmed: 32625311google scholar: lookup
                                              12. Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Gropp J, Kolar B, Kouba M, López-Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Anguita M, Dujardin B, Galobart J, Innocenti ML. Guidance on the assessment of the safety of feed additives for the consumer.. EFSA J 2017 Oct;15(10):e05022.
                                                doi: 10.2903/j.efsa.2017.5022pmc: PMC7009902pubmed: 32625312google scholar: lookup
                                              13. Rychen G, Aquilina G, Azimonti G, Bampidis V, Bastos ML, Bories G, Chesson A, Cocconcelli PS, Flachowsky G, Gropp J, Kolar B, Kouba M, López-Alonso M, López Puente S, Mantovani A, Mayo B, Ramos F, Saarela M, Villa RE, Wallace RJ, Wester P, Anguita M, Galobart J, Innocenti ML, Martino L. Guidance on the assessment of the efficacy of feed additives.. EFSA J 2018 May;16(5):e05274.
                                                doi: 10.2903/j.efsa.2018.5274pmc: PMC7009555pubmed: 32625911google scholar: lookup
                                              14. Bampidis V, Bastos M, Christensen H, Dusemund B, Kouba M, Kos Durjava M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brock T, de Knecht J, Kolar B, van Beelen P, Padovani L, Tarrés-Call J, Vettori MV, Azimonti G. Guidance on the assessment of the safety of feed additives for the environment.. EFSA J 2019 Apr;17(4):e05648.
                                                doi: 10.2903/j.efsa.2019.5648pmc: PMC7009194pubmed: 32626279google scholar: lookup
                                              15. EFSA FEEDAP Panel (EFSA Panel on Additives and Products or Substances used in Animal Feed). General approach to assess the safety for the target species of botanical preparations which contain compounds that are genotoxic and/or carcinogenic.. 2021.
                                              16. EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). Scientific Opinion on the substantiation of health claims related to various food(s)/food constituent(s) claiming maintenance of joints (ID 1799, 1973, 2022, 2178, 2202, 2254, 2255, 2311, 2394, 2417, 2418, 2458, 2649, 2794, 2798, 3119, 3144, 3274, 3283, 3318, 3339, 3495, 3511, 3523, 3555, 3624, 3699, 3748, 3770, 3835, 3884, 3892, 3904, 3943, 3978, 4012, 4020, 4056, 4137, 4175), maintenance of bone (ID 1764, 1907, 2418, 4012, 4020, 4056, 4175) and maintenance of muscles (ID 2254, 2311) pursuant to Article 13(1) of Regulation (EC) No 1924/2006.. EFSA Journal 2010;8(2):1493, 22 pp.
                                                doi: 10.2903/j.efsa.2010.1493google scholar: lookup
                                              17. EFSA Scientific Committee. Guidance on safety assessment of botanicals and botanical preparations intended for use as ingredients in food supplements, on request of EFSA.. EFSA Journal 2009;7(9):1249, 19 pp.
                                                doi: 10.2093/j.efsa.2009.1249google scholar: lookup
                                              18. Hardy A, Benford D, Halldorsson T, Jeger MJ, Knutsen KH, More S, Mortensen A, Naegeli H, Noteborn H, Ockleford C, Ricci A, Rychen G, Silano V, Solecki R, Turck D, Aerts M, Bodin L, Davis A, Edler L, Gundert-Remy U, Sand S, Slob W, Bottex B, Abrahantes JC, Marques DC, Kass G, Schlatter JR. Update: use of the benchmark dose approach in risk assessment.. EFSA J 2017 Jan;15(1):e04658.
                                                doi: 10.2903/j.efsa.2017.4658pmc: PMC7009819pubmed: 32625254google scholar: lookup
                                              19. More SJ, Bampidis V, Benford D, Bennekou SH, Bragard C, Halldorsson TI, Hernández-Jerez AF, Koutsoumanis K, Naegeli H, Schlatter JR, Silano V, Nielsen SS, Schrenk D, Turck D, Younes M, Benfenati E, Castle L, Cedergreen N, Hardy A, Laskowski R, Leblanc JC, Kortenkamp A, Ragas A, Posthuma L, Svendsen C, Solecki R, Testai E, Dujardin B, Kass GE, Manini P, Jeddi MZ, Dorne JC, Hogstrand C. Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals.. EFSA J 2019 Mar;17(3):e05634.
                                                doi: 10.2903/j.efsa.2019.5634pmc: PMC7009070pubmed: 32626259google scholar: lookup
                                              20. More S, Bampidis V, Benford D, Boesten J, Bragard C, Halldorsson T, Hernandez-Jerez A, Hougaard-Bennekou S, Koutsoumanis K, Naegeli H, Nielsen SS, Schrenk D, Silano V, Turck D, Younes M, Aquilina G, Crebelli R, Gürtler R, Hirsch-Ernst KI, Mosesso P, Nielsen E, Solecki R, Carfì M, Martino C, Maurici D, Parra Morte J, Schlatter J. Genotoxicity assessment of chemical mixtures.. EFSA J 2019 Jan;17(1):e05519.
                                                doi: 10.2903/j.efsa.2019.5519pmc: PMC7009058pubmed: 32626066google scholar: lookup
                                              21. More SJ, Bampidis V, Benford D, Bragard C, Halldorsson TI, Hernández-Jerez AF, Hougaard Bennekou S, Koutsoumanis KP, Machera K, Naegeli H, Nielsen SS, Schlatter JR, Schrenk D, Silano V, Turck D, Younes M, Gundert-Remy U, Kass GEN, Kleiner J, Rossi AM, Serafimova R, Reilly L, Wallace HM. Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment.. EFSA J 2019 Jun;17(6):e05708.
                                                doi: 10.2903/j.efsa.2019.5708pmc: PMC7009090pubmed: 32626331google scholar: lookup
                                              22. EMA (European Medicines Agency). Public statement on the use of herbal medicinal products containing methyleugenol.. 2005.
                                              23. EMA (European Medicines Agency). Public statement on the use of herbal medicinal products containing estragole. 2nd Draft, Revision 1, EMA/HMPC/137212/2005 Rev 1.. 2019.
                                              24. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction.. J Chromatogr A 2006 Apr 21;1112(1-2):255-62.
                                                pubmed: 16364338doi: 10.1016/j.chroma.2005.11.116google scholar: lookup
                                              25. Gerbeth K, Hüsch J, Fricker G, Werz O, Schubert-Zsilavecz M, Abdel-Tawab M. In vitro metabolism, permeation, and brain availability of six major boswellic acids from Boswellia serrata gum resins.. Fitoterapia 2013 Jan;84:99-106.
                                                pubmed: 23103296doi: 10.1016/j.fitote.2012.10.009google scholar: lookup
                                              26. Hamm S, Bleton J, Connan J, Tchapla A. A chemical investigation by headspace SPME and GC-MS of volatile and semi-volatile terpenes in various olibanum samples.. Phytochemistry 2005 Jun;66(12):1499-514.
                                                pubmed: 15922374doi: 10.1016/j.phytochem.2005.04.025google scholar: lookup
                                              27. Hüsch J, Bohnet J, Fricker G, Skarke C, Artaria C, Appendino G, Schubert-Zsilavecz M, Abdel-Tawab M. Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract.. Fitoterapia 2013 Jan;84:89-98.
                                                pubmed: 23092618doi: 10.1016/j.fitote.2012.10.002google scholar: lookup
                                              28. IARC (International Agency for Research on Cancer). IARC Monographs 101. Methyleugenol.. 2018.
                                              29. Krishnaraju AV, Sundararaju D, Vamsikrishna U, Suryachandra R, Machiraju G, Sengupta K, Trimurtulu G. Safety and toxicological evaluation of Aflapin: a novel Boswellia-derived anti-inflammatory product.. Toxicol Mech Methods 2010 Nov;20(9):556-63.
                                                pubmed: 20874664doi: 10.3109/15376516.2010.497978google scholar: lookup
                                              30. Krüger P, Daneshfar R, Eckert GP, Klein J, Volmer DA, Bahr U, Müller WE, Karas M, Schubert-Zsilavecz M, Abdel-Tawab M. Metabolism of boswellic acids in vitro and in vivo.. Drug Metab Dispos 2008 Jun;36(6):1135-42.
                                                pubmed: 18356270doi: 10.1124/dmd.107.018424google scholar: lookup
                                              31. Lalithakumari K, Krishnaraju AV, Sengupta K, Subbaraju GV, Chatterjee A. Safety and Toxicological Evaluation of a Novel, Standardized 3-O-Acetyl-11-keto-beta-Boswellic Acid (AKBA)-Enriched Boswellia serrata Extract (5-Loxin(R)).. Toxicol Mech Methods 2006;16(4):199-226.
                                                pubmed: 20021046doi: 10.1080/15376520600620232google scholar: lookup
                                              32. Magesh V, Raman D, Pudupalayam KY. Genotoxicity studies of dry extract of Boswellia serrata.. Tropical Journal of Pharmaceutical Research 2008;7:1129–1135.
                                              33. Miller EC, Swanson AB, Phillips DH, Fletcher TL, Liem A, Miller JA. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.. Cancer Res 1983 Mar;43(3):1124-34.
                                                pubmed: 6825084
                                              34. . NTP Toxicology and Carcinogenesis Studies of Methyleugenol (CAS NO. 93-15-2) in F344/N Rats and B6C3F1 Mice (Gavage Studies).. Natl Toxicol Program Tech Rep Ser 2000 Jul;491:1-412.
                                                pubmed: 12563349
                                              35. PhEur (European Pharmacopoeia). “Indian Frankincense” (Olibanum indicum).. European Pharmacopoeia 2020;10th Edition. Monograph 01/2013:2310.
                                              36. Phillips DH, Reddy MV, Randerath K. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice.. Carcinogenesis 1984 Dec;5(12):1623-8.
                                                pubmed: 6499113doi: 10.1093/carcin/5.12.1623google scholar: lookup
                                              37. Randerath K, Haglund RE, Phillips DH, Reddy MV. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice.. Carcinogenesis 1984 Dec;5(12):1613-22.
                                                pubmed: 6499112doi: 10.1093/carcin/5.12.1613google scholar: lookup
                                              38. Sangster SA, Caldwell J, Hutt AJ, Anthony A, Smith RL. The metabolic disposition of [methoxy-14C]-labelled trans-anethole, estragole and p-propylanisole in human volunteers.. Xenobiotica 1987 Oct;17(10):1223-32.
                                                pubmed: 3424869doi: 10.3109/00498258709167414google scholar: lookup
                                              39. Sharma N, Bhardwaj V, Singh S, Ali SA, Gupta DK, Paul S, Satti NK, Chandra S, Verma MK. Simultaneous quantification of triterpenoic acids by high performance liquid chromatography method in the extracts of gum resin of Boswellia serrata obtained by different extraction techniques.. Chem Cent J 2016;10:49.
                                                pmc: PMC4973369pubmed: 27493682doi: 10.1186/s13065-016-0194-8google scholar: lookup
                                              40. Sharma A, Chhikara S, Ghodekar SN, Bathia S, Kharya MD, Gajbhiye V, Mann AS, Namdeo AG, Mahadik KR. Phytochemical and Pharmacological investigations on Boswellia serrata.. Pharmacognosy Reviews 2009;5:206–215.
                                              41. Sharma R, Singh S, Singh GD, Khajuria A, Sidiq T, Singh SK, Chashoo G, Pagoch SS, Kaul A, Saxena AK, Johri RK, Taneja SC. In vivo genotoxicity evaluation of a plant based antiarthritic and anticancer therapeutic agent Boswelic acids in rodents.. Phytomedicine 2009 Dec;16(12):1112-8.
                                                pubmed: 19679457doi: 10.1016/j.phymed.2009.06.009google scholar: lookup
                                              42. Siemoneit U, Pergola C, Jazzar B, Northoff H, Skarke C, Jauch J, Werz O. On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance.. Eur J Pharmacol 2009 Mar 15;606(1-3):246-54.
                                                pubmed: 19374837doi: 10.1016/j.ejphar.2009.01.044google scholar: lookup
                                              43. Singh GB, Bani S, Singh S. Toxicity and safety evaluation of boswellic acids.. Phytomedicine 1996 May;3(1):87-90.
                                                pubmed: 23194869doi: 10.1016/s0944-7113(96)80018-3google scholar: lookup
                                              44. Singh P, Chacko KM, Aggarwal ML, Bhat B, Khandal RK, Sultana S, Kuruvilla BT. A-90 Day Gavage Safety Assessment of Boswellia serrata in Rats.. Toxicol Int 2012 Sep;19(3):273-8.
                                                pmc: PMC3532773pubmed: 23293466doi: 10.4103/0971-6580.103668google scholar: lookup
                                              45. Suparmi S, Ginting AJ, Mariyam S, Wesseling S, Rietjens IMCM. Levels of methyleugenol and eugenol in instant herbal beverages available on the Indonesian market and related risk assessment.. Food Chem Toxicol 2019 Mar;125:467-478.
                                                pubmed: 30721739doi: 10.1016/j.fct.2019.02.001google scholar: lookup
                                              46. Tisserand R, Young R. Essential oil safety. A Guide for Health Care Professionals. 2nd Edition. Chapter 13. Essential oil profiles. 2014, Elsevier Ltd. pp. 287–289.
                                                doi: 10.1016/C2009-0-52351-3google scholar: lookup
                                              47. Yin MC, Lin MC, Mong MC, Lin CY. Bioavailability, distribution, and antioxidative effects of selected triterpenes in mice.. J Agric Food Chem 2012 Aug 8;60(31):7697-701.
                                                pubmed: 22816768doi: 10.1021/jf302529xgoogle scholar: lookup
                                              48. Zangouras A, Caldwell J, Hutt AJ, Smith RL. Dose dependent conversion of estragole in the rat and mouse to the carcinogenic metabolite, 1'-hydroxyestragole.. Biochem Pharmacol 1981 Jun 1;30(11):1383-6.
                                                pubmed: 7271835doi: 10.1016/0006-2952(81)90329-4google scholar: lookup
                                              49. Zhang Y, Ning Z, Lu C, Zhao S, Wang J, Liu B, Xu X, Liu Y. Triterpenoid resinous metabolites from the genus Boswellia: pharmacological activities and potential species-identifying properties.. Chem Cent J 2013 Sep 12;7(1):153.
                                                pmc: PMC3847453pubmed: 24028654doi: 10.1186/1752-153x-7-153google scholar: lookup
                                              50. Zhou GD, Moorthy B, Bi J, Donnelly KC, Randerath K. DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human (HepG2) cells.. Environ Mol Mutagen 2007 Dec;48(9):715-21.
                                                pubmed: 17948277doi: 10.1002/em.20348google scholar: lookup

                                              Citations

                                              This article has been cited 15 times.
                                              1. Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Schlatter J, Westendorf J, Dirven Y, Manini P, Dusemund B. Safety and efficacy of a feed additive consisting of an essential oil derived from the fruit of Illicium verum Hook.f. (star anise oil) for use in all animal species (FEFANA asbl).. EFSA J 2023 Jul;21(7):e08182.
                                                doi: 10.2903/j.efsa.2023.8182pubmed: 37529619google scholar: lookup
                                              2. Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Schlatter J, Westendorf J, Dirven Y, Manini P, Dusemund B. Safety and efficacy of feed additives consisting of essential oils derived from the flower buds or the leaves of Syzygium aromaticum (L.) Merr. & L.M. Perry (clove bud oil and clove leaf oils) for all animal species (FEFANA asbl).. EFSA J 2023 Jul;21(7):e08183.
                                                doi: 10.2903/j.efsa.2023.8183pubmed: 37522096google scholar: lookup
                                              3. Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Schlatter J, Westendorf J, Manini P, Dusemund B. Safety and efficacy of a feed additive consisting of an essential oil from the seeds of Myristica fragrans Houtt. (nutmeg oil) for all animal species (FEFANA asbl).. EFSA J 2023 Jun;21(6):e08066.
                                                doi: 10.2903/j.efsa.2023.8066pubmed: 37333988google scholar: lookup
                                              4. Cho MK, Jin JS, Jo Y, Han JH, Shin S, Bae SJ, Ryu D, Joo J, Park JK, Ha KT. Frankincense ameliorates endometriosis via inducing apoptosis and reducing adhesion.. Integr Med Res 2023 Jun;12(2):100947.
                                                doi: 10.1016/j.imr.2023.100947pubmed: 37168676google scholar: lookup
                                              5. Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of feed additives obtained from the fruit of Pimpinella anisum L.: anise oil for use in poultry and horses and anise tincture for use in poultry, dogs, cats and horses (FEFANA asbl).. EFSA J 2023 Apr;21(4):e07976.
                                                doi: 10.2903/j.efsa.2023.7976pubmed: 37089173google scholar: lookup
                                              6. Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of a tincture derived from the fruit of Pimpinella anisum L. (anise tincture) for use in all animal species (FEFANA asbl).. EFSA J 2023 Apr;21(4):e07962.
                                                doi: 10.2903/j.efsa.2023.7962pubmed: 37077302google scholar: lookup
                                              7. Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Schlatter J, Schrenk D, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of an essential oil from the leaves of Laurus nobilis L. (laurel leaf oil) for all animal species (FEFANA asbl).. EFSA J 2023 Mar;21(3):e07875.
                                                doi: 10.2903/j.efsa.2023.7875pubmed: 36908566google scholar: lookup
                                              8. Cattaneo I, Kalian AD, Di Nicola MR, Dujardin B, Levorato S, Mohimont L, Nathanail AV, Carnessechi E, Astuto MC, Tarazona JV, Kass GEN, Liem AKD, Robinson T, Manini P, Hogstrand C, Price PS, Dorne JLCM. Risk Assessment of Combined Exposure to Multiple Chemicals at the European Food Safety Authority: Principles, Guidance Documents, Applications and Future Challenges.. Toxins (Basel) 2023 Jan 4;15(1).
                                                doi: 10.3390/toxins15010040pubmed: 36668860google scholar: lookup
                                              9. Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of a tincture derived from the fruit of Anethum graveolens L. (dill tincture) for use in all animal species (FEFANA asbl).. EFSA J 2023 Jan;21(1):e07691.
                                                doi: 10.2903/j.efsa.2023.7691pubmed: 36655164google scholar: lookup
                                              10. Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of a tincture derived from the fruit of Foeniculum vulgare Mill. ssp. vulgare var. dulce (sweet fennel tincture) for use in all animal species (FEFANA asbl).. EFSA J 2023 Jan;21(1):e07693.
                                                doi: 10.2903/j.efsa.2023.7693pubmed: 36620493google scholar: lookup
                                              11. Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of a tincture derived from the fruit of Petroselinum crispum (Mill.) Fuss (parsley tincture) for use in all animal species (FEFANA asbl).. EFSA J 2023 Jan;21(1):e07694.
                                                doi: 10.2903/j.efsa.2023.7694pubmed: 36620492google scholar: lookup
                                              12. Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of an essential oil from the aerial parts of Anethum graveolens L. (dill herb oil) for use in dogs and cats (FEFANA asbl).. EFSA J 2022 Dec;20(12):e07689.
                                                doi: 10.2903/j.efsa.2022.7689pubmed: 36570349google scholar: lookup
                                              13. Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Schlatter J, Schrenk D, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of an essential oil from the fruit of Cuminum cyminum L. (cumin oil) for use in all animal species (FEFANA asbl).. EFSA J 2022 Dec;20(12):e07690.
                                                doi: 10.2903/j.efsa.2022.7690pubmed: 36545574google scholar: lookup
                                              14. Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of a feed additive consisting of a tincture derived from the fruit of Illicium verum Hook f. (star anise tincture) for use in all animal species (FEFANA asbl).. EFSA J 2022 Dec;20(12):e07695.
                                                doi: 10.2903/j.efsa.2022.7695pubmed: 36540777google scholar: lookup
                                              15. Bampidis V, Azimonti G, Bastos ML, Christensen H, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Chesson A, Schlatter J, Schrenk D, Westendorf J, Manini P, Pizzo F, Dusemund B. Safety and efficacy of feed additives consisting of essential oils from the bark and the leaves of Cinnamomum verum J. Presl (cinnamon bark oil and cinnamon leaf oil) for use in all animal species (FEFANA asbl).. EFSA J 2022 Oct;20(10):e07601.
                                                doi: 10.2903/j.efsa.2022.7601pubmed: 36304835google scholar: lookup
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