Safety of omeprazole paste in foals and mature horses.
Abstract: Omeprazole has been shown to promote healing of spontaneously occurring gastric ulcers in horses when administered for 28 days at a dose of 4 mg/kg bwt/day and to prevent recurrence of ulcers in almost all horses when treatment is continued at a dose of at least 2 mg/kg bwt/day. The purpose of the 3 studies reported here was to 1) evaluate the evolution of potential effects of omeprazole paste (GastroGard), at a dose of 20 mg/kg bwt/day (5x the recommended dose) for 91 days in mature Thoroughbred horses; 2) evaluate the safety in young horses of omeprazole paste when dosed at 4 mg/kg bwt/day (1x), 12 mg/kg bwt/day (3x) or 20 mg/kg bwt/day (5x) for 91 days in Tennessee walking horse foals; and 3) evaluate the safety of omeprazole paste when dosed at 40 mg/kg bwt/day (10x) for 21 days in mature Thoroughbred horses. Within each study, horses were allocated randomly to the control or omeprazole paste treatment group. Clinical examinations, serum biochemistry and haematology were performed at regular intervals until necropsy at the end of the study. There were no treatment-related clinical signs in any treated horse and serum biochemistry and haematology were normal. In conclusion, omeprazole paste is safe for use in horses as demonstrated in studies with foals and mature horses.
Publication Date: 2000-03-04 PubMed ID: 10696297DOI: 10.1111/j.2042-3306.1999.tb05172.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Clinical Trial
- Journal Article
- Randomized Controlled Trial
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The study investigates the safety of administering high doses of omeprazole paste to mature Thoroughbred horses and foals for extended periods. The study confirmed that omeprazole paste given in repeated high doses for specified periods showed no negative effects on treated horses and foals, suggesting its safe use in such animals.
Research Goals
- The primary aim of the research was to explore the safety and potential effects of omeprazole paste administered at a high dose for an extended period to mature horses.
- The research further aimed to evaluate the safety of different doses of the paste given to foals over a similar timeframe.
- Finally, the research sought to ascertain the safety of the paste when given at a very high dose to mature horses over a shorter period.
Methodology
- In each of the three studies, horses were randomly allocated to either a control group or a group receiving omeprazole paste treatment.
- The doses tested dimmed from the recommended dose to up to 10 times that dose.
- The horses were studied over periods ranging from 21 to 91 days.
- Regular clinical examinations, serum biochemistry, and haematology were performed throughout the study.
Results
- The results of the studies showed no treatment-related clinical signs in any of the treated horses.
- Horses’ serum biochemistry and haematology results were normal, indicating no negative impact on their health due to the treatment.
- The results suggest that administering omeprazole paste at the studied doses for the explored periods is safe for horses, both mature and foals.
Cite This Article
APA
Plue RE, Wall HG, Daurio C, Attebery DK, Cox JL, Wallace DH.
(2000).
Safety of omeprazole paste in foals and mature horses.
Equine Vet J Suppl(29), 63-66.
https://doi.org/10.1111/j.2042-3306.1999.tb05172.x Publication
Researcher Affiliations
- Merial Limited, Missouri Research Center, Fulton 65251, USA.
MeSH Terms
- Administration, Oral
- Animals
- Animals, Newborn
- Enzyme Inhibitors / administration & dosage
- Enzyme Inhibitors / adverse effects
- Enzyme Inhibitors / blood
- Female
- Horse Diseases / prevention & control
- Horses / metabolism
- Male
- Ointments
- Omeprazole / administration & dosage
- Omeprazole / adverse effects
- Omeprazole / blood
- Single-Blind Method
- Stomach / drug effects
- Stomach Ulcer / prevention & control
- Stomach Ulcer / veterinary
Citations
This article has been cited 1 times.- Doucet MY, Vrins AA, Dionne R, Alva R, Ericsson G. Efficacy of a paste formulation of omeprazole for the treatment of naturally occurring gastric ulcers in training standardbred racehorses in Canada. Can Vet J 2003 Jul;44(7):581-5.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
