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Home / Equine Research Bank / J Vet Intern Med / Scoring System for Multiple Organ Dysfunction in Adult Horse...
Journal of veterinary internal medicine2016; 30(4); 1276-1283; doi: 10.1111/jvim.14321

Scoring System for Multiple Organ Dysfunction in Adult Horses with Acute Surgical Gastrointestinal Disease.

Abstract: The prevalence of multiple organ dysfunction syndrome (MODS) in horses with acute surgical gastrointestinal (GI) disease is unknown. Currently, there are no validated criteria to confirm MODS in adult horses. Objective: To develop criteria for a MODS score for horses with acute surgical colic (MODS SGI) and evaluate the association with 6-month survival. To compare the MODS SGI score with a MODS score extrapolated from criteria used in people (MODS EQ). Methods: Adult horses that required exploratory laparotomy (n = 62) for colic. Healthy adult horses undergoing elective surgical procedures (n = 12) established the reference range of some variables. Methods: Prospectively, a MODS SGI score was developed based on organ-specific criteria established from a literature review, data collection, and clinical judgment. Data for scoring each horse were collected on Days 1 and 2 postoperatively. Horses were scored retrospectively using both scoring criteria. The prognostic performance of the MODS SGI score and its overall performance compared with the MODS EQ score were assessed with receiver operating characteristic (ROC) curve analysis. Results: The MODS SGI score had excellent performance for predicting 6-month survival with an area under the ROC curve (AUC) of 0.95 (95% CI: 0.87-0.99). The AUC for the MODS SGI score was significantly higher than the MODS EQ (AUC: 0.76; 0.63-0.86). Conclusions: The MODS SGI score predicts 6-month survival from discharge in horses with acute surgical colic. The MODS SGI score performed better than a score extrapolated from human scoring systems.
Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2016-06-14 PubMed ID: 27296454PubMed Central: PMC5094519DOI: 10.1111/jvim.14321Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study focuses on developing a scoring system for multiple organ dysfunction syndrome (MODS) in adult horses undergoing surgery for gastrointestinal disorders. The researchers found that their new scoring system effectively predicts a horse’s chance of survival six months after surgery, performing better than an existing scoring model designed for humans.

Study Design and Population

  • The researchers examined adult horses that had exploratory laparotomy because of colic symptoms. A total of 62 horses were included in the study.
  • Additionally, 12 healthy adult horses undergoing planned surgical procedures were used as a reference to set a range of some variables.

Establishing the Scoring System

  • A MODS score for surgical gastrointestinal (SGI) disease in horses (MODS SGI) was devised to predict a horse’s six-month survival outlook after surgery.
  • The criteria for the MODS SGI score were created based on organ-specific criteria derived from a literature review, data collection and clinical judgment.
  • Data for scoring each horse were collected on days 1 and 2 postoperatively.

Comparison with Human MODS Score

  • The researchers compared their MODS SGI score with a MODS score extrapolated from criteria employed in human medicine (MODS EQ).
  • The retrospective scoring of horses was done using both scoring systems to make a performance comparison.

Outcome Evaluation with ROC Curve Analysis

  • The predictive capabilities of the MODS SGI score and its overall performance compared to the MODS EQ score were evaluated using receiver operating characteristic (ROC) curve analysis.
  • The Area Under the ROC Curve (AUC) for the MODS SGI score was 0.95, indicating excellent performance in predicting six-month survival. The 95% Confidence Interval (CI) was between 0.87 and 0.99.
  • The AUC for the MODS EQ score was significantly lower at 0.76, with the 95% CI between 0.63 and 0.86, demonstrating the superiority of the horse-specific scoring system.

Conclusions

  • The hemorrhage-specific MODS SGI score was successful in predicting six-month survival in horses with acute surgical colic.
  • The MODS SGI score showed better predictive performance than the extrapolated human MODS EQ score. This result underscores the importance of species-specific scoring systems in disease management and prognosis.

Cite This Article

APA
McConachie E, Giguère S, Barton MH. (2016). Scoring System for Multiple Organ Dysfunction in Adult Horses with Acute Surgical Gastrointestinal Disease. J Vet Intern Med, 30(4), 1276-1283. https://doi.org/10.1111/jvim.14321

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 30
Issue: 4
Pages: 1276-1283

Researcher Affiliations

McConachie, E
  • Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA.
Giguère, S
  • Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA.
Barton, M H
  • Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA.

MeSH Terms

  • Animals
  • Area Under Curve
  • Colic / surgery
  • Colic / veterinary
  • Horse Diseases / classification
  • Horse Diseases / pathology
  • Horse Diseases / surgery
  • Horses
  • Organ Dysfunction Scores
  • Systemic Inflammatory Response Syndrome / pathology
  • Systemic Inflammatory Response Syndrome / veterinary

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