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Home / Equine Research Bank / Reprod Biol Endocrinol / Seasonal variation in equine follicular fluid proteome.
Reproductive biology and endocrinology : RB&E2019; 17(1); 29; doi: 10.1186/s12958-019-0473-z

Seasonal variation in equine follicular fluid proteome.

Abstract: Proteomic studies of follicular fluid (FF) exist for several species, including the horse; however, the seasonal influence on FF proteome has not been explored in livestock. The application of high-throughput proteomics of FF in horse has the potential to identify seasonal variations of proteins involved in follicle and oocyte growth. Methods: This study (i) profiles the proteomes of equine FF collected from dominant growing follicles during the spring anovulatory season (SAN), and spring (SOV), summer (SUM), and fall (FOV) ovulatory seasons; and (ii) identifies season-dependent regulatory networks and associated key proteins. Results: Regardless of season, a total of 90 proteins were identified in FF, corresponding to 63, 72, 69, and 78 proteins detected in the SAN, SOV, SUM, and FOV seasons, respectively. Fifty-two proteins were common to all seasons, a total of 13 were unique to either season, and 25 were shared between two seasons or more. Protein-to-protein interaction (PPI) analysis indicated the likely critical roles of plasminogen in the SAN season, the prothrombin/plasminogen combination in SUM, and plasminogen/complement C3 in both SOV and FOV seasons. The apolipoprotein A1 appeared crucial in all seasons. The present findings show that FF proteome of SUM differs from other seasons, with FF having high fluidity (low viscosity). Conclusions: The balance between the FF contents in prothrombin, plasminogen, and coagulation factor XII proteins favoring FF fluidity may be crucial at the peak of the ovulatory season (SUM) and may explain the reported lower incidence of hemorrhagic anovulatory follicles during the SUM season.
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Publication Date: 2019-03-06 PubMed ID: 30841911PubMed Central: PMC6404268DOI: 10.1186/s12958-019-0473-zGoogle Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research explores the impact of seasonal variations on the protein content in horse follicular fluid (FF), a substance that nurtures the development of egg cells (oocytes) within the ovaries. The study finds out that these variations, particularly during the summer ovulatory season, could influence the fluidity of the FF, potentially reducing the chances of hemorrhagic non-ovulating follicles.

Objective and Methods

  • The aim of this research was to explore the seasonal effect on the protein composition of equine follicular fluid. The intent was to uncover peculiarities in protein presence and interaction, which could aid comprehension of follicle and oocyte development in different seasons.
  • The research team used advanced proteomic methods to profile FF proteins in dominant growing follicles across four seasons: spring anovulatory season (SAN), spring ovulatory season (SOV), summer (SUM), and fall (FOV).
  • Using this data, the team identified season-dependent regulatory networks and key proteins affecting the performance of FF during these periods.

Results

  • The team identified 90 proteins in FF, regardless of the season. Different seasons exhibited specific subsets of these proteins: 63 in SAN, 72 in SOV, 69 in SUM, and 78 in FOV.
  • Of these, 52 proteins were common to all seasons, 13 were season-specific, and 25 were shared between at least two seasons.
  • Upon analyzing protein-to-protein interaction (PPI), the team discerned pivotal roles of certain proteins in various seasons. For instance, plasminogen was crucial in the SAN season, a union of prothrombin and plasminogen was important in SUM, and a partnership of plasminogen and complement C3 was significant in both SOV and FOV seasons.
  • Apolipoprotein A1 was found critical in all seasons.
  • Summer season’s FF proteome was notably distinct from other seasons and was characterized by high fluidity (or low viscosity).

Conclusions

  • The researchers concluded that the balance between prothrombin, plasminogen, and coagulation factor XII proteins in FF during the summer, leading to increased fluidity, might be a crucial factor behind the reported lower incidence of hemorrhagic non-ovulating follicles.
  • Such insights could potentially aid in solving fertility-related issues and optimizing breeding practices in horses and other livestock.

Cite This Article

APA
Dutra GA, Ishak GM, Pechanova O, Pechan T, Peterson DG, Jacob JCF, Willard ST, Ryan PL, Gastal EL, Feugang JM. (2019). Seasonal variation in equine follicular fluid proteome. Reprod Biol Endocrinol, 17(1), 29. https://doi.org/10.1186/s12958-019-0473-z

Publication

Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
NlmUniqueID: 101153627
Country: England
Language: English
Volume: 17
Issue: 1
Pages: 29
PII: 29

Researcher Affiliations

Dutra, G A
  • Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL, USA.
  • Department of Reproduction and Animal Evaluation, Federal Rural University of Rio de Janeiro, Seropédica, Brazil.
Ishak, G M
  • Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL, USA.
  • Department of Surgery and Obstetrics, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq.
Pechanova, O
  • Institute for Genomics, Biocomputing and Bioinformatics, University, Mississippi State, Oxford, MS, USA.
Pechan, T
  • Institute for Genomics, Biocomputing and Bioinformatics, University, Mississippi State, Oxford, MS, USA.
Peterson, D G
  • Institute for Genomics, Biocomputing and Bioinformatics, University, Mississippi State, Oxford, MS, USA.
Jacob, J C F
  • Department of Reproduction and Animal Evaluation, Federal Rural University of Rio de Janeiro, Seropédica, Brazil.
Willard, S T
  • Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, 4025 Wise Center, PO Box 9815, Mississippi State, MS, 39762, USA.
Ryan, P L
  • Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, 4025 Wise Center, PO Box 9815, Mississippi State, MS, 39762, USA.
Gastal, E L
  • Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL, USA.
Feugang, J M
  • Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, 4025 Wise Center, PO Box 9815, Mississippi State, MS, 39762, USA. jn181@ads.msstate.edu.

MeSH Terms

  • Animals
  • Female
  • Follicular Fluid / metabolism
  • Horses / metabolism
  • Proteins / chemistry
  • Proteins / isolation & purification
  • Proteins / metabolism
  • Proteomics
  • Reproduction
  • Seasons

Grant Funding

  • P20 GM103476 / NIGMS NIH HHS
  • 8-6402-3-018 / USDA-ARS
  • 4P20GM103476-15 / National Institutes of Health

Conflict of Interest Statement

ETHICS APPROVAL: All animal care and experimental protocols used in this study were approved by the institutional animal care and the ethic committee of Southern Illinois University. CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors declare that they have no competing interests. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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