Sedative effects of detomidine and midazolam combination in horses.
Abstract: The combination of detomidine and midazolam may provide safer sedation with muscle-relaxant effects, which are particularly necessary during standing procedures. Unassigned: Thus, the objective of this study was to evaluate the sedative and muscle-relaxant effects of the detomidine/midazolam combination in horses through a pharmacodynamic study. Unassigned: Five horses were used and subjected to four experimental protocols: 15 µg/kg of detomidine (D15); a combination of detomidine (15 µg/kg) with 25 µg/kg (DM25), 50 µg/kg (DM50), or 75 µg/kg (DM75) of midazolam administered intravenously. The sedative and muscle-relaxant effects, as well as physiological parameters, were evaluated and statistically analyzed. Unassigned: All protocols resulted in a decrease in head height, although no significant difference was observed among them. The acoustic stimulus response and tongue tone relaxation showed significant effects in the global analysis. Unassigned: This study contributes to our understanding of the application of this combination in equine sedation protocols.
Publication Date: 2025-07-31 PubMed ID: 41036345PubMed Central: PMC12483408DOI: 10.5455/OVJ.2025.v15.i7.5Google Scholar: Lookup
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Cite This Article
APA
Gomes ÉR, Felix LA, Gonzaga LWF, da Silva NFD, Soares BCF, de Almeida JVFC, Souza GP, Pereira RN, Taffarel MO, Ferrante M.
(2025).
Sedative effects of detomidine and midazolam combination in horses.
Open Vet J, 15(7), 2938-2947.
https://doi.org/10.5455/OVJ.2025.v15.i7.5 Publication
Researcher Affiliations
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
- Department of Veterinary Medicine, State University of Maringá, Maringá, Brazil.
- Department of Veterinary Medicine, Federal University of Lavras, Lavras, Brazil.
MeSH Terms
- Animals
- Midazolam / administration & dosage
- Midazolam / pharmacology
- Horses / physiology
- Hypnotics and Sedatives / pharmacology
- Hypnotics and Sedatives / administration & dosage
- Imidazoles / administration & dosage
- Imidazoles / pharmacology
- Male
- Female
- Drug Therapy, Combination / veterinary
Conflict of Interest Statement
The authors declare that they have no conflicts of interest.
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