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Sepsis-induced cardiomyopathy in animals: From experimental studies to echocardiography-based clinical research.
Abstract: The term "sepsis-induced cardiomyopathy" (SIC) is used to describe transient cardiac dysfunction in septic patients. However, there is no universally accepted definition of SIC; a reduction in left ventricular ejection fraction (LVEF) is often used. In addition to systolic dysfunction, diastolic dysfunction is now recognized as an essential component of SIC. It can be emphasized that previous animal experiments played an essential role in revealing SIC and hemodynamic instability in sepsis and septic shock. The diagnostic and prognostic capabilities of echocardiography for the assessment of SIC have been extensively studied since its introduction into intensive care clinical practice. Recent studies in dogs, calves, and horses have shown that left and right ventricular systolic dysfunction, left ventricular diastolic dysfunction, and circulatory dysfunction can occur in sepsis, severe sepsis, and septic shock in animals. Echocardiographic variables have also shown that indices of left and right ventricular dysfunction and circulatory failure are valuable indicators of mortality in septic animals. Le terme « cardiomyopathie induite par la septicémie » (SIC) est utilisé pour décrire un dysfonctionnement cardiaque transitoire chez les patients septiques. Cependant, il n’y a pas de définition universellement acceptée du SIC; une réduction de la fraction d’éjection ventriculaire gauche (FEVG) est souvent utilisée. En plus de la dysfonction systolique, la dysfonction diastolique est maintenant reconnue comme une composante essentielle du SIC. On peut souligner que les expérimentations animales antérieures ont joué un rôle essentiel dans la révélation du SIC et de l’instabilité hémodynamique dans la septicémie et le choc septique. Les capacités diagnostiques et pronostiques de l’échocardiographie pour l’évaluation du SIC ont été largement étudiées depuis son introduction dans la pratique clinique des soins intensifs. Des études récentes sur des chiens, des veaux et des chevaux ont révélé qu’un dysfonctionnement systolique ventriculaire gauche et droit, un dysfonctionnement diastolique ventriculaire gauche et un dysfonctionnement circulatoire peuvent survenir dans la septicémie, la septicémie sévère et le choc septique chez les animaux. Les variables échocardiographiques ont également démontré que les indices de dysfonctionnement ventriculaire gauche et droit et d’insuffisance circulatoire sont des indicateurs précieux de la mortalité chez les animaux septiques.(Traduit par D Serge Messier).
Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.
Publication Date: 2023-09-04 PubMed ID: 37663026PubMed Central: PMC10426250 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
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Summary
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The research paper investigates how sepsis, a severe infection, can induce temporary cardiac dysfunction, referred to as sepsis-induced cardiomyopathy (SIC), in animals. The paper highlights the importance of echocardiography, a ultrasound-based technique to visualize the heart and its function, in diagnosing and predicting outcomes in cases of SIC.
Understanding Sepsis-induced Cardiomyopathy (SIC)
- SIC is a term used to refer to a temporary heart dysfunction in animals with sepsis. While there’s no universal definition for SIC, a reduced left ventricular ejection fraction (LVEF) is commonly used as a measure.
- Beyond just systolic dysfunction, this research highlights that diastolic dysfunction is equally crucial in SIC.
Role of Animal Experiments
- Animal studies have been pivotal in understanding the relationship between sepsis and heart dysfunction. They have provided insights into SIC and hemodynamic instability—a situation where the blood circulation is not adequate—in septic shock.
Echocardiography in Clinical Practice
- Echocardiography’s diagnostic and prognostic capabilities have been extensively explored since the method was introduced in intensive care. As a non-invasive and quick method, it is widely used for assessing cardiac function in septic patients.
Recent Studies & Findings
- The paper references recent research conducted on dogs, calves, and horses. The studies reveal that left and right ventricular systolic dysfunction, left ventricular diastolic dysfunction, and circulatory dysfunction are outcomes of sepsis, severe sepsis, and septic shock in these animals.
- Echocardiographic variables have been shown to be effective in predicting mortality in septic animals. Hence, they are useful indicators of left and right ventricular dysfunction and circulatory failure.
Conclusion
- The research underscores the importance of echocardiography in diagnosing and understanding the proprieties of SIC. As well as its substantial role in predicting outcomes, particularly mortality, in septic animals.
Cite This Article
APA
Naseri A, Akyuz E, Turgut K, Guzelbektes H, Sen I.
(2023).
Sepsis-induced cardiomyopathy in animals: From experimental studies to echocardiography-based clinical research.
Can Vet J, 64(9), 871-877.
Publication
Researcher Affiliations
- Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Tu00fcrkiye (Naseri, Guzelbektes); Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, Kars, Tu00fcrkiye (Akyuz); Department of Internal Medicine, Faculty of Veterinary Medicine, Near East University, Nicosia, North Cyprus, Tu00fcrkiye (Turgut); Department of Internal Medicine, Faculty of Veterinary Medicine, Kyrgyz Turkish Manas University, Bishkek, Kyrgyzstan (Sen).
- Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Tu00fcrkiye (Naseri, Guzelbektes); Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, Kars, Tu00fcrkiye (Akyuz); Department of Internal Medicine, Faculty of Veterinary Medicine, Near East University, Nicosia, North Cyprus, Tu00fcrkiye (Turgut); Department of Internal Medicine, Faculty of Veterinary Medicine, Kyrgyz Turkish Manas University, Bishkek, Kyrgyzstan (Sen).
- Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Tu00fcrkiye (Naseri, Guzelbektes); Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, Kars, Tu00fcrkiye (Akyuz); Department of Internal Medicine, Faculty of Veterinary Medicine, Near East University, Nicosia, North Cyprus, Tu00fcrkiye (Turgut); Department of Internal Medicine, Faculty of Veterinary Medicine, Kyrgyz Turkish Manas University, Bishkek, Kyrgyzstan (Sen).
- Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Tu00fcrkiye (Naseri, Guzelbektes); Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, Kars, Tu00fcrkiye (Akyuz); Department of Internal Medicine, Faculty of Veterinary Medicine, Near East University, Nicosia, North Cyprus, Tu00fcrkiye (Turgut); Department of Internal Medicine, Faculty of Veterinary Medicine, Kyrgyz Turkish Manas University, Bishkek, Kyrgyzstan (Sen).
- Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Tu00fcrkiye (Naseri, Guzelbektes); Department of Internal Medicine, Faculty of Veterinary Medicine, Kafkas University, Kars, Tu00fcrkiye (Akyuz); Department of Internal Medicine, Faculty of Veterinary Medicine, Near East University, Nicosia, North Cyprus, Tu00fcrkiye (Turgut); Department of Internal Medicine, Faculty of Veterinary Medicine, Kyrgyz Turkish Manas University, Bishkek, Kyrgyzstan (Sen).
MeSH Terms
- Animals
- Cattle
- Dogs
- Horses
- Shock, Septic / veterinary
- Stroke Volume
- Ventricular Function, Left
- Sepsis / complications
- Sepsis / veterinary
- Cardiomyopathies / diagnostic imaging
- Cardiomyopathies / veterinary
- Echocardiography / veterinary
- Cattle Diseases
- Dog Diseases / diagnostic imaging
- Dog Diseases / etiology
- Horse Diseases
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