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Home / Equine Research Bank / Am J Trop Med Hyg / Serological investigation of heartland virus (Bunyaviridae: ...
The American journal of tropical medicine and hygiene2015; 92(6); 1163-1167; doi: 10.4269/ajtmh.14-0702

Serological investigation of heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013.

Abstract: Heartland virus (HRTV; Bunyaviridae: Phlebovirus) has recently emerged as a causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States. The lone star tick (Amblyomma americanum L.) has been implicated as a vector. To identify candidate vertebrate amplification hosts associated with enzootic maintenance of the virus, sera and ticks were sampled from 160 mammals (8 species) and 139 birds (26 species) captured near 2 human case residences in Andrew and Nodaway Counties in northwest Missouri. HRTV-specific neutralizing antibodies were identified in northern raccoons (42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%), but not in birds. Virus isolation attempts from sera and ticks failed to detect HRTV. The high antibody prevalence coupled with local abundance of white-tailed deer and raccoons identifies these species as candidate amplification hosts.
© The American Society of Tropical Medicine and Hygiene.
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Publication Date: 2015-04-13 PubMed ID: 25870419PubMed Central: PMC4458820DOI: 10.4269/ajtmh.14-0702Google Scholar: Lookup
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  • Journal Article
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study focuses on the investigation of Heartland virus exposure in both wild and domestic animals in close proximity to human case sites. A wide variety of animals including mammals and birds were sampled, with the discovery of Heartland virus-specific antibodies in several mammals but not in birds.

Focus of the Study

  • The study conducted involves the Heartland virus (HRTV), a disease-causing agent that has emerged recently in the United States and is associated with low platelet and white blood cell counts in humans.
  • The focus of the study is to identify potential vertebrate hosts that could play a role in supporting the Heartland virus. This is done through sampling sera (a component of blood) and ticks from various animals.

Sampling and Locations

  • The researchers took samples from a total of 160 mammals from 8 species and also 139 birds representing 26 species.
  • This sampling was performed near residences of two humans who had contracted the virus in two counties in northwest Missouri: Andrew and Nodaway Counties.

Findings

  • The isolation attempts of the virus from sera and ticks were unsuccessful. However, the researchers managed to identify HRTV-specific neutralizing antibodies in several mammalian species, an indication of exposure to the virus.
  • Such antibodies were found in northern raccoons (with a prevalence of 42.6%), horses (17.4%), white-tailed deer (14.3%), dogs (7.7%), and Virginia opossums (3.8%). However, the study did not identify any such antibodies in birds indicating that they likely do not play a role in the spread of the virus.

Implications

  • The findings showed a high prevalence of HRTV-specific antibodies in certain species of mammals, particularly the local species of white-tailed deer and raccoons.
  • Due to the high prevalence of these antibodies and abundance of these species, the researchers identified them as potential amplification hosts for the Heartland virus, suggesting they could be contributing to its propagation.

Cite This Article

APA
Bosco-Lauth AM, Panella NA, Root JJ, Gidlewski T, Lash RR, Harmon JR, Burkhalter KL, Godsey MS, Savage HM, Nicholson WL, Komar N, Brault AC. (2015). Serological investigation of heartland virus (Bunyaviridae: Phlebovirus) exposure in wild and domestic animals adjacent to human case sites in Missouri 2012-2013. Am J Trop Med Hyg, 92(6), 1163-1167. https://doi.org/10.4269/ajtmh.14-0702

Publication

The American journal of tropical medicine and hygiene
ISSN: 1476-1645
NlmUniqueID: 0370507
Country: United States
Language: English
Volume: 92
Issue: 6
Pages: 1163-1167

Researcher Affiliations

Bosco-Lauth, Angela M
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Panella, Nicholas A
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Root, J Jeffrey
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Gidlewski, Tom
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Lash, R Ryan
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Harmon, Jessica R
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Burkhalter, Kristen L
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Godsey, Marvin S
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Savage, Harry M
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Nicholson, William L
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Komar, Nicholas
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia.
Brault, Aaron C
  • Division of Vector-Borne Diseases, Arboviral Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado; U.S. Department of Agriculture, Wildlife Services, National Wildlife Research Center, Fort Collins, Colorado; Division of Vector-Borne Diseases, Rickettsial Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia abrault@cdc.gov.

MeSH Terms

  • Animals
  • Animals, Domestic / virology
  • Animals, Wild / virology
  • Birds / virology
  • Bunyaviridae Infections / epidemiology
  • Bunyaviridae Infections / veterinary
  • Bunyaviridae Infections / virology
  • Deer / virology
  • Didelphis / virology
  • Disease Vectors
  • Horses / virology
  • Humans
  • Missouri / epidemiology
  • Neutralization Tests
  • Phlebovirus
  • Raccoons / virology
  • Ticks / virology
  • Zoonoses / epidemiology
  • Zoonoses / virology

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This article has been cited 39 times.
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