FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Vector Borne Zoonotic Dis / Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesti...
Vector borne and zoonotic diseases (Larchmont, N.Y.)2020; 20(10); 797-799; doi: 10.1089/vbz.2019.2592

Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesticated Animals in Northwestern Senegal.

Abstract: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that can be contracted by direct contact with viremic animals or humans. In West Africa, recurrent CCHF outbreaks have been constantly observed in Mauritania and Senegal. Moreover, acquisition and epidemiology of the infection in humans are correlated with the occurrence and the seroprevalence of the virus in livestock. The main objective of this study is to provide updated information on the local spread of CCHF in animals in the northern region of Senegal. Out of a total of 283 animal sera collected, CCHF-specific antibodies were identified in 92 (32.5%; confidence interval [CI] 27.1-38.3) sera by double antigen sandwich enzyme-linked immunosorbent assay (ELISA) test. The prevalence of CCHF virus (CCHFV) infection among horses, cattle, sheep, dogs, donkeys, and goats was 70.3% (45/64), 57.1% (8/14), 22.1% (30/136), 18.2% (2/11), 17.2% (5/29), and 6.9% (2/29), respectively. The antibody titers were found significantly affected by age ( < 0.0001) and gender ( < 0.05). High tick infestation by spp. and spp. was recorded on horses. The high seroprevalence to CCHFV among animals in the northern region of Senegal observed in this study indicates the permanent presence of the infection in the northern region of the country suggesting the need to strengthen surveillance plans for CCHF in Senegal.
Get Full Text
Publication Date: 2020-05-19 PubMed ID: 32429789DOI: 10.1089/vbz.2019.2592Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research focuses on investigating the prevalence of Crimean-Congo Hemorrhagic Fever (CCHF) in domesticated animals in Northwestern Senegal. The results found a high prevalence of the infection, indicating a potential risk for human transmission and highlighting the need for improved surveillance strategies.

Understanding the Study

  • The study was conducted to measure the prevalence of Crimean-Congo Hemorrhagic Fever, a tick-borne disease, in domesticated animals in Northwestern Senegal. The motivation behind this research stems from previous observations of recurrent CCHF outbreaks in Senegal and Mauritania and the established link between CCHF infections in livestock and humans.
  • The study team collected sera from a total of 283 animals and tested for CCHF-specific antibodies using a double antigen sandwich enzyme-linked immunosorbent assay (ELISA) test. The animals tested were of different kinds – horses, cattle, sheep, dogs, donkeys, and goats.

Key Findings

  • The results showed CCHF-specific antibodies present in 32.5% of the total animal sera tested, reflecting a significant amount of infection in the region’s livestock. However, the infection rate varied widely among different animal species.
  • Highest prevalence was found in the horses (70.3%) and cattle (57.1%). The disease prevalence was markedly lower in sheep (22.1%), dogs (18.2%), donkeys (17.2%), and goats (6.9%).
  • The study also found significant variations in the antibody titers based on the age and gender of the animals.
  • The researchers noticed high tick infestation on horses, which is a significant factor considering CCHF is a tick-borne disease.

Implications

  • These findings of high seroprevalence among animals in Northwestern Senegal indicates the consistent presence of the infection in the region.
  • Given the potential for human transmission from infected livestock, this poses a significant public health concern.
  • The results underscore the importance of implementing robust surveillance strategies and preventive measures to control the spread of CCHF in Senegal.

Cite This Article

APA
Mangombi JB, Roqueplo C, Sambou M, Dahmani M, Mediannikov O, Comtet L, Davoust B. (2020). Seroprevalence of Crimean-Congo Hemorrhagic Fever in Domesticated Animals in Northwestern Senegal. Vector Borne Zoonotic Dis, 20(10), 797-799. https://doi.org/10.1089/vbz.2019.2592

Publication

Vector borne and zoonotic diseases (Larchmont, N.Y.)
ISSN: 1557-7759
NlmUniqueID: 100965525
Country: United States
Language: English
Volume: 20
Issue: 10
Pages: 797-799

Researcher Affiliations

Mangombi, Joa Braïthe
  • Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.
  • IHU Méditerranée Infection, Marseille, France.
  • Centre International de Recherche Médicale de Franceville (CIRMF), Franceville, Gabon.
Roqueplo, Cédric
  • French Military Health Service, Expertise and Defense Health Strategy Division, Paris, France.
  • French Military Health Service, Animal Epidemiology Working Group, Marseille, France.
Sambou, Masse
  • IHU Méditerranée Infection, Marseille, France.
  • Vectors-Tropical and Mediterranean Infections (VITROME), Campus International UCAD-IRD, Dakar, Senegal.
  • Aix Marseille Univ, IRD, SSA, APHM, VITROME, IHU Méditerranée Infection, Marseille, France.
Dahmani, Mustapha
  • Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.
  • IHU Méditerranée Infection, Marseille, France.
Mediannikov, Oleg
  • Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.
  • IHU Méditerranée Infection, Marseille, France.
Comtet, Loïc
  • IDVet, Grabels, France.
Davoust, Bernard
  • Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.
  • IHU Méditerranée Infection, Marseille, France.
  • French Military Health Service, Animal Epidemiology Working Group, Marseille, France.

MeSH Terms

  • Animals
  • Antibodies, Viral / blood
  • Dog Diseases / virology
  • Dogs
  • Female
  • Hemorrhagic Fever Virus, Crimean-Congo / isolation & purification
  • Hemorrhagic Fever, Crimean / blood
  • Hemorrhagic Fever, Crimean / epidemiology
  • Hemorrhagic Fever, Crimean / veterinary
  • Livestock / virology
  • Male
  • Prevalence
  • Senegal
  • Seroepidemiologic Studies
  • Tick Infestations / veterinary
  • Ticks

Citations

This article has been cited 27 times.
  1. Sankhe S, Talla C, Thiam MS, Faye M, Barry MA, Diarra M, Dia M, Ndiaye O, Sembene PM, Diop B, Fall G, Faye O, Faye O, Diagne MM, Loucoubar C. Seroprevalence of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in human population in Senegal from October to November 2020. IJID Reg 2023 Jun;7:216-221.
    doi: 10.1016/j.ijregi.2023.03.016pubmed: 37153883google scholar: lookup
  2. Simo Tchetgna H, Yousseu FS, Cosset FL, de Freitas NB, Kamgang B, McCall PJ, Ndip RN, Legros V, Wondji CS. Molecular and serological evidence of Crimean-Congo hemorrhagic fever orthonairovirus prevalence in livestock and ticks in Cameroon. Front Cell Infect Microbiol 2023;13:1132495.
    doi: 10.3389/fcimb.2023.1132495pubmed: 37056704google scholar: lookup
  3. Atim SA, Niebel M, Ashraf S, Vudriko P, Odongo S, Balinandi S, Aber P, Bameka R, Ademun AR, Masembe C, Tweyongyere R, Thomson EC. Prevalence of Crimean-Congo haemorrhagic fever in livestock following a confirmed human case in Lyantonde district, Uganda. Parasit Vectors 2023 Jan 7;16(1):7.
    doi: 10.1186/s13071-022-05588-xpubmed: 36611216google scholar: lookup
  4. Atim SA, Ashraf S, Belij-Rammerstorfer S, Ademun AR, Vudriko P, Nakayiki T, Niebel M, Shepherd J, Balinandi S, Nakanjako G, Abaasa A, Johnson PCD, Odongo S, Esau M, Bahati M, Kaleebu P, Lutwama JJ, Masembe C, Lambe T, Thomson EC, Tweyongyere R. Risk factors for Crimean-Congo Haemorrhagic Fever (CCHF) virus exposure in farming communities in Uganda. J Infect 2022 Dec;85(6):693-701.
    doi: 10.1016/j.jinf.2022.09.007pubmed: 36108783google scholar: lookup
  5. Garcia K, Weakley M, Do T, Mir S. Current and Future Molecular Diagnostics of Tick-Borne Diseases in Cattle. Vet Sci 2022 May 21;9(5).
    doi: 10.3390/vetsci9050241pubmed: 35622769google scholar: lookup
  6. González Gordon L, Bessell PR, Nkongho EF, Ngwa VN, Tanya VN, Sander M, Ndip L, Morgan KL, Handel IG, Mazeri S, Bronsvoort BM, Kelly RF. Seroepidemiology of Crimean-Congo Haemorrhagic Fever among cattle in Cameroon: Implications from a One Health perspective. PLoS Negl Trop Dis 2022 Mar;16(3):e0010217.
    doi: 10.1371/journal.pntd.0010217pubmed: 35312678google scholar: lookup
  7. Phonera MC, Simuunza MC, Kainga H, Ndebe J, Chembensofu M, Chatanga E, Kanyanda S, Changula K, Muleya W, Mubemba B, Chitanga S, Kajihara M, Sawa H, Njunga G, Takada A, Simulundu E. Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever in Cattle of Smallholder Farmers in Central Malawi. Pathogens 2021 Dec 10;10(12).
    doi: 10.3390/pathogens10121613pubmed: 34959568google scholar: lookup
  8. Zhang Y, Hu B, Agwanda B, Fang Y, Wang J, Kuria S, Yang J, Masika M, Tang S, Lichoti J, Fan Z, Shi Z, Ommeh S, Wang H, Deng F, Shen S. Viromes and surveys of RNA viruses in camel-derived ticks revealing transmission patterns of novel tick-borne viral pathogens in Kenya. Emerg Microbes Infect 2021 Dec;10(1):1975-1987.
    doi: 10.1080/22221751.2021.1986428pubmed: 34570681google scholar: lookup
  9. Gilbride C, Saunders J, Sharpe H, Maze EA, Limon G, Ludi AB, Lambe T, Belij-Rammerstorfer S. The Integration of Human and Veterinary Studies for Better Understanding and Management of Crimean-Congo Haemorrhagic Fever. Front Immunol 2021;12:629636.
    doi: 10.3389/fimmu.2021.629636pubmed: 33815379google scholar: lookup
  10. Davoust B, Watier-Grillot S, Roqueplo C, Raoult D, Mediannikov O. Detection of zoonotic pathogens in animals performed at the University Hospital Institute Méditerranée Infection (Marseille - France). One Health 2021 Jun;12:100210.
    doi: 10.1016/j.onehlt.2020.100210pubmed: 33437857google scholar: lookup
  11. Mekata H, Yamamoto M, Matsuu A, Maeda K, Isawa H, Yoshii K, Umeki K, Okabayashi T. Development of a Double-Antigen Sandwich ELISA for Oz Virus and a Seroepidemiological Survey in Wild Boars in Miyazaki, Japan. Pathogens 2025 Dec 14;14(12).
    doi: 10.3390/pathogens14121288pubmed: 41471243google scholar: lookup
  12. Matulis G, Potter AM, Lilak AA, Pecor DB, Rodriguez D, Wood L, Cerimele R, Stone K, Cleary NG, Butler K, Linton YM, von Fricken ME. A compilation of ticks and tick-borne pathogen distributions in seven countries within North and West Africa from 1901 to 2022: a systematic literature review. Parasit Vectors 2025 Dec 4;19(1):13.
    doi: 10.1186/s13071-025-07153-8pubmed: 41345951google scholar: lookup
  13. Miletic G, Coric I, Kovac S, Skrinjaric A, Kamber Taslaman M, Bozikovic M, Barbic L, Masovic V, Prpic J, Jemersic L, Stevanovic V. First Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus Infections in Croatia: A Multispecies Surveillance Approach Emphasising the Role of Sentinel Hosts. Viruses 2025 Sep 30;17(10).
    doi: 10.3390/v17101335pubmed: 41157606google scholar: lookup
  14. Sene O, Sagne SN, Ngom D, Bocoum M, Diallo MK, Khoulé A, Faye ET, Diop SM, Diallo I, Loucoubar C, Diallo M, Dia N, Sall Y, Diop B, Ndiaye M, Sall AA, Weidmann M, Diagne MM, Fall M, Faye O, Faye O, Simon-Lorière E, Diallo D, Barry MA, Fall G. Crimean-Congo Hemorrhagic Fever Outbreak in Podor, Northern Senegal in 2022: Two Independent Emergences and Unprecedented Mortality. Am J Trop Med Hyg 2025 Sep 3;113(3):555-563.
    doi: 10.4269/ajtmh.24-0445pubmed: 40628243google scholar: lookup
  15. Sadio BD, Ngom D, Sow B, Diagne CT, Gaye A, Khoulé A, Sène O, Faye E, Mhamadi M, Camara D, Sylla CN, Diaby FG, Traoré M, Ndiaye O, Mbaye KA, Cissé K, Diop B, Ndiaye EHM, Sall Y, Mbengue A, Sow A, Sall AA, Faye O, Faye M, Dia N, Diallo M, Diagne MM, Fall G, Diallo D. Re-emergence of Crimean Congo hemorrhagic fever virus in Kedougou, south-eastern Senegal in 2023: Epidemiological and zoological investigations of the first symptomatic human case. One Health 2025 Jun;20:101040.
    doi: 10.1016/j.onehlt.2025.101040pubmed: 40342870google scholar: lookup
  16. Yessinou RE, Farougou S, Olopade JO, Oluwayelu DO, Happi A, Happi C, Groschup M. Seroprevalence and Risk Factors of Crimean-Congo Hemorrhagic Fever Exposure in Wild and Domestic Animals in Benin. Viruses 2025 Mar 8;17(3).
    doi: 10.3390/v17030387pubmed: 40143315google scholar: lookup
  17. Celina SS, Italiya J, Tekkara AO, Černý J. Crimean-Congo haemorrhagic fever virus in ticks, domestic, and wild animals. Front Vet Sci 2024;11:1513123.
    doi: 10.3389/fvets.2024.1513123pubmed: 39897158google scholar: lookup
  18. Dahourou LD, Savadogo M, Dera MK, Abga LR, Ouoba BL, Arnaud Tapsoba RS, Yougbare B, Akio S, Zerbo LH, Traore A, Alambedji RB. Detection of Crimean-Congo hemorrhagic fever virus antibodies in cattle in Kenedougou and Mouhoun provinces in Burkina Faso. Open Vet J 2024 Aug;14(8):1912-1920.
    doi: 10.5455/OVJ.2024.v14.i8.19pubmed: 39308728google scholar: lookup
  19. Gahn MCB, Diouf G, Cissé N, Ciss M, Bordier M, Ndiaye M, Bakhoum MT, Djiba ML, Brown C, Faburay B, Fall AG, Lo MM. Large-Scale Serological Survey of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in Small Ruminants in Senegal. Pathogens 2024 Aug 15;13(8).
    doi: 10.3390/pathogens13080689pubmed: 39204289google scholar: lookup
  20. Ngom D, Khoulé A, Faye ET, Sène O, Diop SM, Sagne SN, Diallo MK, Dia M, Barry MA, Diaw Y, Bocoum M, Ndiaye EHM, Sall Y, Diop B, Faye O, Faye O, Diallo M, Simon-Lorière E, Sakuntabhai A, Fall G, Diallo D. Crimean-Congo haemorrhagic fever outbreak in Northern Senegal in 2022: Prevalence of the virus in livestock and ticks, associated risk factors and epidemiological implications. Zoonoses Public Health 2024 Sep;71(6):696-707.
    doi: 10.1111/zph.13136pubmed: 38627964google scholar: lookup
  21. Sene O, Sagne SN, Ngom D, Diagne MM, Badji A, Khoulé A, Ndiaye EH, Sankhe S, Loucoubar C, Diallo M, Weidmann M, Dia N, Simon-Lorière E, Sall Y, Diop B, Ndiaye M, Sakuntabhai A, Sall AA, Faye O, Faye O, Diallo D, Barry MA, Fall G. Emergence of Crimean-Congo Hemorrhagic Fever Virus in Eastern Senegal in 2022. Viruses 2024 Feb 19;16(2).
    doi: 10.3390/v16020315pubmed: 38400090google scholar: lookup
  22. El Ghassem A, Abdoullah B, Deida J, Ould Lemrabott MA, Ouldabdallahi Moukah M, Ould Ahmedou Salem MS, Briolant S, Basco LK, Ould Brahim K, Ould Mohamed Salem Boukhary A. Arthropod-Borne Viruses in Mauritania: A Literature Review. Pathogens 2023 Nov 20;12(11).
    doi: 10.3390/pathogens12111370pubmed: 38003834google scholar: lookup
  23. Nyakarahuka L, Kyondo J, Telford C, Whitesell A, Tumusiime A, Mulei S, Baluku J, Cossaboom CM, Cannon DL, Montgomery JM, Lutwama JJ, Nichol ST, Balinandi SK, Klena JD, Shoemaker TR. Seroepidemiological investigation of Crimean Congo hemorrhagic fever virus in livestock in Uganda, 2017. PLoS One 2023;18(11):e0288587.
    doi: 10.1371/journal.pone.0288587pubmed: 37943886google scholar: lookup
  24. El Ghassem A, Apolloni A, Vial L, Bouvier R, Bernard C, Khayar MS, Cheikh Ahmed M, Fausther-Bovendo H, Beyit AD, Yahya B, Ould El Mamy MB, Elbara A, Bollahi MA, Cêtre-Sossah C, Ould Mohamed Salem Boukhary A. Risk factors associated with Crimean-Congo hemorrhagic fever virus circulation among human, livestock and ticks in Mauritania through a one health retrospective study. BMC Infect Dis 2023 Nov 6;23(1):764.
    doi: 10.1186/s12879-023-08779-8pubmed: 37932678google scholar: lookup
  25. Omoga DCA, Tchouassi DP, Venter M, Ogola EO, Osalla J, Kopp A, Slothouwer I, Torto B, Junglen S, Sang R. Transmission Dynamics of Crimean-Congo Haemorrhagic Fever Virus (CCHFV): Evidence of Circulation in Humans, Livestock, and Rodents in Diverse Ecologies in Kenya. Viruses 2023 Sep 7;15(9).
    doi: 10.3390/v15091891pubmed: 37766297google scholar: lookup
  26. Matthews J, Secka A, McVey DS, Dodd KA, Faburay B. Serological Prevalence of Crimean-Congo Hemorrhagic Fever Virus Infection in Small Ruminants and Cattle in The Gambia. Pathogens 2023 May 23;12(6).
    doi: 10.3390/pathogens12060749pubmed: 37375439google scholar: lookup
  27. Temur AI, Kuhn JH, Pecor DB, Apanaskevich DA, Keshtkar-Jahromi M. Epidemiology of Crimean-Congo Hemorrhagic Fever (CCHF) in Africa-Underestimated for Decades. Am J Trop Med Hyg 2021 Apr 26;104(6):1978-1990.
    doi: 10.4269/ajtmh.20-1413pubmed: 33900999google scholar: lookup
Subscribe to our newsletter
Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.