Serum concentrations of ormetoprim/sulphadimethoxine in 1-3-day-old foals after a single dose of oral paste combination.
Abstract: Ormetoprim (OMP)/sulphadimethoxine (SDM) combinations
have been used in the treatment of fowl cholera, colibacillosis,
salmonellosis, infectious coryza, and other bacterial infections in
poultry (Mitrovic et al. 1969; Maestrone et al. 1979). The drug
combination has also been used in the treatment of colibacillosis
in neonatal pigs (Brandt and Maestrone 1980) and Pasteurella
pneumonia in cattle (Ames et al. 1987). Serum concentrations and
pharmacokinetics of SDM (Oh-Ishi and Nakajima 1964; Durr et
al. 1980) and OMP/SDM (Brown et al. 1989) after intravenous or
oral administration to adult horses have been reported. After oral
administration to mares, both drugs are variably absorbed, but
penetrate synovial fluid, peritoneal fluid and endometrium readily
(Brown et al. 1989). Elimination half-lives (t1,2) for OMP and
SDM were 1.45 h and 13.53 h, respectively, in foals 7-9 weeks of
age given an oral paste preparation of the drug combination
(Baggot and Short 1984). The purpose of this study was to
determine the serum concentrations of OMP and SDM in 1-3-
day-old foals after a single oral dose and compare these values
with those in adult horses (Brown et al. 1989).
Publication Date: 1993-01-01 PubMed ID: 8422891DOI: 10.1111/j.2042-3306.1993.tb02906.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- Non-P.H.S.
Summary
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The research investigates the serum concentrations of two drugs, ormetoprim and sulphadimethoxine, in young (1-3 day old) foals following a single dose, comparing the outcomes with existing data from adult horses.
Objective of the Study
- The primary objective of this study was to measure and compare the serum concentrations of Ormetoprim (OMP) and Sulphadimethoxine (SDM) in newborn foals (1-3 days old) after they have been administered a single oral dose. This data was then compared with already established results from adult horses.
Background of the Research
- Previous research has found OMP/SDM combinations to be effective in treating various bacterial infections in poultry, such as fowl cholera, colibacillosis, salmonellosis, and infectious coryza. This drug combination is also used for treating colibacillosis in neonatal pigs and Pasteurella pneumonia in cattle.
- Prior studies have reported serum concentrations and pharmacokinetics of SDM and OMP/SDM after they were administered intravenously or orally to adult horses. The drugs showed variable absorption rates when given orally to mares, and were found to penetrate synovial fluid, peritoneal fluid, and endometrium effectively.
- In foals aged 7-9 weeks, elimination half-lives for OMP and SDM were recorded to be 1.45 hours and 13.53 hours respectively, after administering the drug combination in an oral paste preparation.
Significance of the Study
- The results of this study can provide valuable insight into how OMP and SDM function in newborn foals. Understanding how serum concentrations of these drugs change in young foals compared with adult horses can help veterinarians and scientists better tailor drug dosages and timing for maximum efficacy.
Cite This Article
APA
Brown MP, Gronwall RR, Cook LK, Houston AE.
(1993).
Serum concentrations of ormetoprim/sulphadimethoxine in 1-3-day-old foals after a single dose of oral paste combination.
Equine Vet J, 25(1), 73-74.
https://doi.org/10.1111/j.2042-3306.1993.tb02906.x Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
MeSH Terms
- Administration, Oral
- Animals
- Animals, Newborn / metabolism
- Drug Combinations
- Horses / metabolism
- Ointments
- Pyrimidines / administration & dosage
- Pyrimidines / blood
- Pyrimidines / pharmacokinetics
- Sulfadimethoxine / administration & dosage
- Sulfadimethoxine / blood
- Sulfadimethoxine / pharmacokinetics
Citations
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