Setaria digitata in advancing our knowledge of human lymphatic filariasis.
Abstract: Setaria digitata is a filarial parasite that causes fatal cerebrospinal nematodiasis in goats, sheep and horses, resulting in substantial economic losses in animal husbandry in the tropics. Due to its close resemblance to Wuchereria bancrofti, this nematode is also frequently used as a model organism to study human lymphatic filariasis. This review highlights numerous insights into the morphological, histological, biochemical, immunological and genetic aspects of S. digitata that have broadened our understanding towards the control and eradication of filarial diseases.
Publication Date: 2015-04-30 PubMed ID: 25924635DOI: 10.1017/S0022149X15000309Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research article demonstrates how the filarial parasite Setaria digitata, which impacts livestock, provides understanding in the study of human lymphatic filariasis due to its similarity to the Wuchereria bancrofti nematode. The study delves into the various aspects of S. digitata, leading to insights beneficial to the control and eradication of filarial diseases.
Morphological and Histological Observations
- The study begins with an examination of the morphological and histological characteristics of Setaria digitata.This is crucial as understanding these aspects would contribute to the broader understanding of its life cycle, reproductive behaviour and how it affects its hosts.
Biochemical Findings
- The researchers also dived into the biochemical traits of S. digitata, including the enzymes it produces, and its metabolic activity. These insights are vital as they directly relate to the parasite’s survivability and virulence.
Immunological Investigation
- An essential part of the review is the understanding of the immunological response against Setaria digitata. This information is crucial because it is directly related to how hosts respond to infections by the parasite, which could inform the development of vaccines or treatments.
Genetic Analysis
- The study also explores a genetic study of S. digitata.The genetic make-up of the parasite can reveal a lot about its survival mechanisms, resistance to treatments, and potential vulnerabilities that could be exploited for novel treatments.
Application to Understanding Lymphatic Filariasis
- Lastly, the study examines the usefulness of all these findings in understanding human lymphatic filariasis. The findings from studies on S. digitata can help shed light on Wuchereria bancrofti, due to their close resemblance. This knowledge is potentially highly beneficial in guiding efforts towards the control and eradication of human lymphatic filariasis, a significant health problem in many parts of the world.
Cite This Article
APA
Perumal AN, Gunawardene YI, Dassanayake RS.
(2015).
Setaria digitata in advancing our knowledge of human lymphatic filariasis.
J Helminthol, 90(2), 129-138.
https://doi.org/10.1017/S0022149X15000309 Publication
Researcher Affiliations
- Department of Chemistry,Faculty of Science, University of Colombo,Sri Lanka.
- Molecular Medicine Unit, Faculty of Medicine, University of Kelaniya, Ragama,Sri Lanka.
- Department of Chemistry,Faculty of Science, University of Colombo,Sri Lanka.
MeSH Terms
- Animals
- Elephantiasis, Filarial / parasitology
- Elephantiasis, Filarial / pathology
- Elephantiasis, Filarial / therapy
- Humans
- Setaria Nematode
- Setariasis / epidemiology
- Setariasis / parasitology
- Setariasis / pathology
Citations
This article has been cited 15 times.- Adhikari R, Acharya D, Wagle A. Sociodemographic characteristics as predictors of knowledge regarding mode of transmission of Lymphatic Filariasis among population of Nepal. PLOS Glob Public Health 2022;2(10):e0000082.
- Sureshan M, Prabhu D, Rajamanikandan S, Saraboji K. Discovery of potent inhibitors targeting Glutathione S-transferase of Wuchereria bancrofti: a step toward the development of effective anti-filariasis drugs. Mol Divers 2023 Feb 16;.
- Abo-Aziza FAM, Hendawy SHM, Abdullah HHAM, El Namaky A, Laidoudi Y, Mediannikov O. Emergent and Neglected Equine Filariosis in Egypt: Species Diversity and Host Immune Response. Pathogens 2022 Aug 27;11(9).
- Abdullah HHAM, Amanzougaghene N, Dahmana H, Louni M, Raoult D, Mediannikov O. Multiple vector-borne pathogens of domestic animals in Egypt. PLoS Negl Trop Dis 2021 Sep;15(9):e0009767.
- Yu F, Liu B, Chen S, Yi Z, Liu X, Zhu Y, Li J. First Molecular Confirmation of Equine Ocular Setaria digitata in China. Vet Sci 2021 Mar 28;8(4).
- Lee H, Hwang H, Ro Y, Kim JH, Lee K, Choi E, Bae Y, So B, Lee I. Setaria digitata was the main cause of equine neurological ataxia in Korea: 50 cases (2015-2016). J Vet Med Sci 2021 Jun 2;83(5):869-875.
- Mrifag R, Lemrabott MA, El Kharrim K, Belghyti D, Basco LK. Setaria labiatopapillosa (Filarioidea, Nematoda) in Moroccan cattle: atypical localization and morphological characterization of females and microfilariae by light and scanning electron microscopy. Parasitol Res 2021 Mar;120(3):911-918.
- Senanayake KS, Söderberg J, Põlajev A, Malmberg M, Karunanayake EH, Tennekoon KH, Samarakoon SR, Bongcam-Rudloff E, Niazi A. The Genome of Setaria digitata: A Cattle Nematode Closely Related to Human Filarial Parasites. Genome Biol Evol 2020 Feb 1;12(2):3971-3976.
- Maharana BR, Potliya S, Ganguly A, Bisla RS, Mishra C, Ganguly I. First report of the isolation and phylogenetic characterization of equine Setaria digitata from India based on mitochondrial COI, 12S rDNA, and nuclear ITS2 sequence data. Parasitol Res 2020 Feb;119(2):473-481.
- M R, Rahi M, Saini P. Zoonotic filariasis and its public health significance: a comprehensive literature review. Front Microbiol 2025;16:1700645.
- Helmi TZ, Farida F, Kasturi A, Rahmah EPL, Winaruddin W, Hanafiah M. Unraveling the morphological and molecular profile of Setaria digitata in Aceh cattle. Open Vet J 2025 Jan;15(1):187-197.
- Anandu S, Tanuj GN, Vijayasarathi MK, Manjusha KM, Samanta S, Bandyopadhyay S, Sankar M. Molecular identification and genetic variability of equine and bovine ocular setariasis in india: molecular profiling by mitochondrial genes. Mol Biol Rep 2024 Aug 24;51(1):932.
- Sureshan M, Rajamanikandan S, Saraboji K. Comprehensive approach to in silico identification and in vitro validation of anti-filarial hit molecules targeting the dimer interface of thioredoxin peroxidase 1 in Wuchereria bancrofti: a progress in anti-filariasis drug development. Mol Divers 2025 Apr;29(2):1393-1413.
- Faghihzadeh Gorji F, Sadr S, Eshrati H, Borji H. An investigation of the prevalence of equine filariosis in North and Northeast of Iran. J Parasit Dis 2024 Mar;48(1):163-167.
- Noack S, Harrington J, Carithers DS, Kaminsky R, Selzer PM. Heartworm disease - Overview, intervention, and industry perspective. Int J Parasitol Drugs Drug Resist 2021 Aug;16:65-89.
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