Small intestine large granular lymphoma in a horse.
Abstract: A 12-year-old Appaloosa gelding was referred to the Texas Veterinary Medical Center with a history of chronic diarrhea and weight loss. At necropsy, numerous oval, craterlike ulcers were observed throughout the small intestine. Histologically, these lesions were composed of a neoplastic proliferation of round cells with intracytoplasmic phosphotungstic acid-hematoxylin-positive granules. The tumor cells stained positively for the CD3 antigen and negatively for a B-cell marker. A diagnosis of large granular lymphoma was based on the morphologic and immunohistochemical characteristics of the neoplasm. The postmortem presentation of this case depicted unusual multifocal, ulcerative lymphomatous lesions throughout the small intestine without involvement of the regional lymph nodes. The histologic and ultrastructural morphology of the neoplastic lymphocytes was similar to that in previously reported cases of abdominal equine large granular lymphomas, but in this case the neoplasm was restricted to the small intestine.
Publication Date: 2001-03-31 PubMed ID: 11280380DOI: 10.1354/vp.38-2-223Google Scholar: Lookup
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Summary
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This article is detailing the diagnosis of a rare type of lymphoma identified in a 12-year-old Appaloosa gelding horse, which was only detected after its death. It underscores the unusual confinement of the disease to the small intestine, distinguishing it from similar past instances where such large granular lymphomas affected other areas.
Background of the Case
- The study came out of a case wherein a 12-year-old Appaloosa gelding horse was brought into the Texas Veterinary Medical Center. The horse had a history of chronic diarrhoea and weight loss.
- Post mortem examination of the horse revealed numerous oval, craterlike ulcers throughout the small intestine.
Diagnostic Findings
- On examination of the ulcers, histologically, they were made up of a new growth or neoplastic proliferation of round cells. These cells contained phosphotungstic acid-hematoxylin-positive granules within their cytoplasm.
- On further analysis with immunohistochemical staining, the tumor cells tested positive for the CD3 antigen, a T-cell marker, and negatively for a B-cell marker. This indicated the presence of a certain type of lymphoma in the horse’s small intestine, known as large granular lymphoma.
Unusual Presentation of the Case
- This particular case was unusual because the entire lymphoma was confined to the small intestine, without any involvement of the regional lymph nodes, a common characteristic in such cases of lymphomas.
- The morphologic and immunohistochemical characteristics of the neoplasm were typical of large granular lymphomas. However, the restriction of this neoplasm to the small intestine was atypical in comparison to previously documented cases of such equine large granular lymphomas, which usually affect other abdominal areas.
Implication of the Findings
- The finding of this case implied that large granular lymphomas can occur exclusively in the small intestine of horses, contrary to previous assumptions. This opens a new horizon for further investigations into the pathophysiology and treatment options for such localized large granular lymphomas.
Cite This Article
APA
Herraez P, Berridge B, Marsh P, Weeks B, Ramiro-Ibañez F.
(2001).
Small intestine large granular lymphoma in a horse.
Vet Pathol, 38(2), 223-226.
https://doi.org/10.1354/vp.38-2-223 Publication
Researcher Affiliations
- Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station 77843, USA.
MeSH Terms
- Animals
- Fatal Outcome
- Horse Diseases / pathology
- Horses
- Immunohistochemistry / veterinary
- Intestinal Mucosa / pathology
- Intestinal Neoplasms / pathology
- Intestinal Neoplasms / veterinary
- Intestine, Small / pathology
- Lymphoma, Large B-Cell, Diffuse / pathology
- Lymphoma, Large B-Cell, Diffuse / veterinary
- Male
- Microscopy, Electron / veterinary
Citations
This article has been cited 3 times.- Amaral CI, Bezerra LS, de Jesus Nascimento AE, da Silva NT, Borges LAB, da Silva PHS, Barbosa LM, Nepomuceno AC, Dos Santos Horta R, Cassali GD, Oliveira AR. Clinical and pathological characterization of a feline intestinal large granular lymphocyte lymphoma (LGLL). Vet Res Commun 2025 May 9;49(4):195.
- Miglio A, Morelli C, Gialletti R, Lauteri E, Sforna M, Marenzoni ML, Antognoni MT. Clinical and immunophenotypic findings in 4 forms of equine lymphoma. Can Vet J 2019 Jan;60(1):33-40.
- Muñoz A, Riber C, Trigo P, Castejón F. Hematopoietic neoplasias in horses: myeloproliferative and lymphoproliferative disorders. J Equine Sci 2009;20(4):59-72.
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