Specificity and reversibility of the training effects on the concentration of Na+,K+-Atpase in foal skeletal muscle.
Abstract: The purpose of the present study was to determine whether training and detraining affect the Na+,K+-ATPase concentration in horse skeletal muscles, and whether these effects are specific for the muscles involved in the training programme. Twenty-four Dutch Warmblood foals age 7 days were assigned randomly to 3 groups: Box (box-rest without training), Training (box-rest with training: short-sprint) and Pasture (pasture without training). Exercise regimens were carried out for 5 months and were followed by 6 months of detraining. Five of the foals in each group were subjected to euthanasia at age 5 months and the remaining foals at 11 months. Muscle samples were collected from the deep part of the gluteus medius, semitendinosus and masseter muscles. The Na+,K+-ATPase concentration was quantified by [3H]ouabain binding. In the Training group, the concentration of Na+,K+-ATPase in gluteus medius and semitendinosus muscle, but not in masseter muscle, showed a relative increase of 20% (P<0.05) as compared to Box foals. After detraining for the subsequent 6 months, the concentration of Na+,K+-ATPase in semitendinosus muscle remained the same, while that in gluteus medius muscle was reduced by 10%. It is concluded that: 1) short-sprint training for 5 months induced an increase of the Na+,K+-ATPase concentration in gluteus medius and semitendinosus muscles of the foal. Interestingly, this effect persisted during the 6 months of the detraining period. Whether the higher Na+,K+-ATPase concentration due to training of young foals leads to a better athletic performance when they become mature still needs to be established; 2) the factors that initiate an increase in Na+,K+-ATPase concentration following training are likely to be located in the muscle itself and 3) the training effect may last for several months after returning to normal activity, especially in muscles containing a high percentage of fast-twitch fibres.
Publication Date: 2001-05-16 PubMed ID: 11352346DOI: 10.2746/042516401776249714Google Scholar: Lookup
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- Clinical Trial
- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This research investigates the impact of training and detraining on the concentration of Na+,K+-ATPase in the skeletal muscles of foals, focusing on variations between muscles used in exercise routines and changes sustained during training breaks.
Study Objective and Methodology
- The primary aim of this study was to observe whether training and subsequent detraining influence the concentration of Na+,K+-ATPase, an enzyme crucial for muscular activity, in horse skeletal muscles. Additionally, the researchers wanted to find out if training impacts are muscle specific.
- They used 24 Dutch Warmblood foals, aged 7 days, divided randomly into three groups: Box (resting without training), Training (rest with short-sprint training), and Pasture (pasture rest without training).
- Each exercise regimen lasted for 5 months, followed by a detraining (resting) period of 6 months.
- At the 5-month mark, five foals of each group were euthanized, and the rest terminated at 11 months, with muscle samples collected from select areas of their bodies.
Key findings
- The researchers discovered that in the Training group, the concentration of Na+,K+-ATPase significantly increased by approximately 20% in the gluteus medius and semitendinosus muscles compared to the Box group, but not in the masseter muscle.
- After a 6-month detraining period, the concentration of Na+,K+-ATPase in semitendinosus muscle remained stable, whereas in the gluteus medius, it decreased by about 10%.
Conclusions
- The short-sprint training regimen increased the concentration of Na+,K+-ATPase in both gluteus medius and semitendinosus muscles of the foals. This effect sustained even during the detraining period. Nevertheless, more research is required to determine if higher Na+,K+-ATPase concentrations due to early training improve athletic performance in grown horses.
- It was suggested that the triggers for increasing Na+,K+-ATPase concentration after training likely reside in the muscle. Furthermore, the training impact appeared to persist for a few months after resuming normal activity, particularly in muscles with a high percentage of fast-twitch fibers.
Cite This Article
APA
Suwannachot P, Verkleij CB, Kocsis S, van Weeren PR, Evertst ME.
(2001).
Specificity and reversibility of the training effects on the concentration of Na+,K+-Atpase in foal skeletal muscle.
Equine Vet J, 33(3), 250-255.
https://doi.org/10.2746/042516401776249714 Publication
Researcher Affiliations
- Department of Veterinary Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
MeSH Terms
- Animals
- Animals, Newborn
- Buttocks
- Enzyme Inhibitors / analysis
- Enzyme Inhibitors / metabolism
- Horses / metabolism
- Housing, Animal
- Muscle, Skeletal / enzymology
- Ouabain / analysis
- Ouabain / metabolism
- Physical Conditioning, Animal / physiology
- Sodium-Potassium-Exchanging ATPase / metabolism
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