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Home / Equine Research Bank / Cells / Spontaneous Sepsis in Adult Horses: From Veterinary to Human...
Cells2023; 12(7); 1052; doi: 10.3390/cells12071052

Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives.

Abstract: Sepsis is a life-threatening disease defined as an organ dysfunction caused by a dysregulated host response to an infection. Early diagnosis and prognosis of sepsis are necessary for specific and timely treatment. However, no predictive biomarkers or therapeutic targets are available yet, mainly due to the lack of a pertinent model. A better understanding of the pathophysiological mechanisms associated with sepsis will allow for earlier and more appropriate management. For this purpose, experimental models of sepsis have been set up to decipher the progression and pathophysiology of human sepsis but also to identify new biomarkers or therapeutic targets. These experimental models, although imperfect, have mostly been performed on a murine model. However, due to the different pathophysiology of the species, the results obtained in these studies are difficult to transpose to humans. This underlines the importance of identifying pertinent situations to improve patient care. As humans, horses have the predisposition to develop sepsis spontaneously and may be a promising model for spontaneous sepsis. This review proposes to give first an overview of the different animal species used to model human sepsis, and, secondly, to focus on adult equine sepsis as a spontaneous model of sepsis and its potential implications for human and veterinary medicine.
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Publication Date: 2023-03-30 PubMed ID: 37048125PubMed Central: PMC10093263DOI: 10.3390/cells12071052Google Scholar: Lookup
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  • Journal Article
  • Review
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the use of adult horses as a model for studying sepsis, a severe life-threatening condition resulting from an infection, in order to develop better diagnosis methods and potential treatments.

Summary of Research Objectives

  • The research aimed to find a reliable model for studying the progression of sepsis and its pathophysiology in humans.
  • The study further aimed to probe into the potential of adult horses as a unique spontaneous model for sepsis.
  • The research aimed at improving the early diagnosis and treatment approaches for sepsis through a deep understanding of its pathophysiology.

The Necessity for a Reliable Model

  • The authors point out that current models, mostly murine, are imperfect and have difficulty providing results applicable to humans due to significant physiological differences.
  • The article emphasizes the need for a model closely mimicking humans to enhance the understanding of sepsis progession and pathophysiology, thereby improving patient care.

Adult Horses as a Spontaneous Model

  • The paper highlights adult horses as potential models for the research of sepsis. Like humans, horses have a predisposition to develop sepsis spontaneously, making them a promising model to study disease processes.
  • The authors suggest that findings from adult equine sepsis could have significant implications for both human and veterinary medicine.

Scope and Limitations

  • The review explores the use of different animal species in modelling human sepsis, focusing specifically on adult horses.
  • While horses may offer a promising model for sepsis study, it’s necessary to approach this with a keen understanding of potential differences in sepsis physiology between horses and humans.

Cite This Article

APA
Blangy-Letheule A, Vergnaud A, Dupas T, Rozec B, Lauzier B, Leroux AA. (2023). Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives. Cells, 12(7), 1052. https://doi.org/10.3390/cells12071052

Publication

Cells
ISSN: 2073-4409
NlmUniqueID: 101600052
Country: Switzerland
Language: English
Volume: 12
Issue: 7
PII: 1052

Researcher Affiliations

Blangy-Letheule, Angélique
  • Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
Vergnaud, Amandine
  • Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
Dupas, Thomas
  • Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
Rozec, Bertrand
  • Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
Lauzier, Benjamin
  • Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
  • CHU Sainte-Justine Research Center, Montreal, QC H3T 1C5, Canada.
Leroux, Aurélia A
  • Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.
  • Department of Clinical Sciences, Equine Veterinary Teaching Hospital (CISCO), Oniris, F-44300 Nantes, France.

MeSH Terms

  • Humans
  • Animals
  • Horses
  • Adult
  • Mice
  • Sepsis / veterinary
  • Sepsis / complications
  • Biomarkers
  • Early Diagnosis

Conflict of Interest Statement

The authors declare no conflict of interest.

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