Spurious hypercreatininemia: 28 neonatal foals (2000-2008).
Abstract: To (1) determine the occurrence of spurious hypercreatininemia in a population of hospitalized foals<2 days old, (2) assess the resolution of the hypercreatininemia, and (3) determine its association with survival in these foals. Methods: Retrospective case series. Methods: 2 Referral hospitals. Methods: Foals442 micromol/L (>5.0 mg/dL) from 2 referral hospitals. Methods: None. Results: The medical records of 33 foals were reviewed. Twenty-eight had spurious hypercreatininemia and 5 had acute renal failure. Admission creatinine was not significantly different between the 2 groups (mean [standard deviation]). The creatinine was 1,202 micromol/L (663 micromol/L) (13.6 mg/dL [7.5 mg/dL]) versus 1,185 micromol/L (787 micromol/L) (13.4 mg/dL [8.9 mg/d]) (P=0.96) in each group, respectively, though BUN at the time of hospital admission was significantly higher for acute renal failure foals (P=0.009). In the spurious group, serum creatinine at admission decreased to 504 micromol/L (380 micromol/L) (5.7 mg/dL [4.3 mg/dL]) by 24 hours, and to 159 micromol/L (80 micromol/L) (1.8 mg/dL [0.9 mg/dL]) at 48 hours, and to 115 micromol/L (44 micromol/L) (1.3 mg/dL [0.5 mg/dL]) at 72 hours. Twenty-three of 28 foals with spurious hypercreatininemia survived to hospital discharge and there was no difference in mean admission creatinine between survivors (1176 micromol/L [628 micromol/L]) (13.3 mg/dL [7.1 mg/dL]) and nonsurvivors (1308 micromol/L [857 micromol/L]) (14.8 mg/dL [9.7 mg/dL]) (P=0.67). Twenty of 28 foals had clinical signs suggestive of neonatal encephalopathy. Conclusions: Creatinine decreased by >50% within the initial 24 hours of standard neonatal therapy and was within the reference interval in all but 1 foal within 72 hours of hospitalization. The diagnosis of neonatal encephalopathy was common in these foals.
Publication Date: 2010-05-22 PubMed ID: 20487253DOI: 10.1111/j.1476-4431.2010.00525.xGoogle Scholar: Lookup
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Summary
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The research studies the occurrence, resolution, and survival impact of incorrect high serum creatinine levels (spurious hypercreatininemia) in neonatal foals less than 2 days old, hospitalized at two referral centers. The findings suggest that more than 50% reduction in creatinine took place within the first 24 hours of standard neonatal therapy, aligning with the normal ranges within 72 hours for almost all foals. Neonatal encephalopathy was a common condition among these foals.
Objective of the Research
- The research aimed to understand the occurrence and resolution of spurious hypercreatininemia in neonatal foals under two days old hospitalized at two referral hospitals.
- It also sought to investigate an association between spurious hypercreatininemia and the animals’ survival.
Methodology
- The study was a retrospective case series analysing the medical records of 33 foals.
- The foals were all less than two days old and had an admission creatinine level higher than 442 micromol/L (which is over 5.0 mg/dL) at the time of hospitalization.
Results
- Out of the 33 foals, 28 showed signs of spurious hypercreatininemia and 5 exhibited acute renal failure.
- The average creatinine level at admission was not significantly different between the two groups.
- The Blood Urea Nitrogen (BUN) at admission was significantly higher for the 5 foals diagnosed with acute renal failure, demonstrating an established correlation between high BUN levels and renal failures.
- For foals with spurious hypercreatininemia, the serum creatinine levels dropped significantly within the first 24 hours and continued to decline thereafter, going back to almost normal levels in 72 hours post hospitalization.
- 23 out of the 28 foals with spurious hypercreatininemia survived until hospital discharge.
- There was no significant difference in the average admission creatinine levels between survivors and non-survivors, demonstrating that the initial hypercreatininemia may not have a strong influence on the foals’ survival.
- A prevalent diagnosis among the foals was neonatal encephalopathy, a condition mainly affecting the central nervous system in newborn foals.
Conclusion
- The study concluded that standard neonatal therapy was effective in reducing the creatinine levels by over 50% within the first 24 hours.
- Almost all foals returned to near-normal levels within 72 hours of hospitalization.
- Further, the study observed no meaningful correlation between high admission creatinine levels in foals and their survival chances.
- It also shed light on the common incidence of neonatal encephalopathy among the foals under study.
Cite This Article
APA
Chaney KP, Holcombe SJ, Schott HC, Barr BS.
(2010).
Spurious hypercreatininemia: 28 neonatal foals (2000-2008).
J Vet Emerg Crit Care (San Antonio), 20(2), 244-249.
https://doi.org/10.1111/j.1476-4431.2010.00525.x Publication
Researcher Affiliations
- Large Animal Medicine and Surgery Academic Program, St George's University, Grenada, West Indies. kchaney@sgu.edu
MeSH Terms
- Acute Kidney Injury / blood
- Acute Kidney Injury / mortality
- Acute Kidney Injury / veterinary
- Animals
- Animals, Newborn
- Blood Urea Nitrogen
- Brain Diseases, Metabolic / blood
- Brain Diseases, Metabolic / therapy
- Brain Diseases, Metabolic / veterinary
- Creatinine / blood
- Female
- Horse Diseases / blood
- Horse Diseases / mortality
- Horse Diseases / therapy
- Horses
- Kidney Diseases / blood
- Kidney Diseases / mortality
- Kidney Diseases / therapy
- Kidney Diseases / veterinary
- Male
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
Citations
This article has been cited 3 times.- Bozorgmanesh R, Thornton J, Snyder J, Fletcher C, Mack R, Coyne M, Murphy R, Hegarty E, Slovis N. Symmetric dimethylarginine concentrations in healthy neonatal foals and mares.. J Vet Intern Med 2021 Nov;35(6):2891-2896.
- Siwinska N, Zak A, Slowikowska M, Niedzwiedz A, Paslawska U. Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury.. BMC Vet Res 2020 Oct 20;16(1):396.
- Savage VL, Marr CM, Bailey M, Smith S. Prevalence of acute kidney injury in a population of hospitalized horses.. J Vet Intern Med 2019 Sep;33(5):2294-2301.
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