STANDARDIZATION OF ANTIMENINGOCOCCIC SERUM.

The study investigated the protective ability of antimeningococcal serum against infection, but concluded that its usefulness in lab animals does not signify its effectiveness in human medicine, and this aspect of the serum is not a superior benchmark of its strength compared to the agglutination titer.

Objective of the Study

• The main objective of this study was to test the protective reaction of antimeningococcal serum against infection to determine its potency.

Methodology and Results

• The researchers conducted various experiments, the outcomes of which revealed considerable variation and apparently bore no causal connection with the quality of the tested sera.
• The quality of sera was evaluated based on factors such as the immunization period of horses from which they were derived, and their perceived efficiency in human cases of epidemic meningitis.
• The study results also showed no conformity with the agglutination titer of the tested sera and were not affected by the different type forms of meningococci.

Conclusion

• The study concluded that the protective property of the antimeningococcal serum in laboratory animals is not a suitable standard measure of its value in human medicine.
• Furthermore, researchers formed the opinion that this feature of the serum is not a better standard for measuring its potency than the agglutination titer.