STANDARDIZATION OF ANTIMENINGOCOCCIC SERUM.
Abstract: Experiments were made for the purpose of testing the reaction of protection against infection as a measure of potency of antimeningococcic serum. The results of the experiments were extremely variable and bore no relation to the quality of the sera as determined by the period of immunization of the horses from which they were obtained, or the indications of efficiency based upon their employment in human cases of epidemic meningitis. The results also failed entirely to conform to the agglutination titer of the sera tested and to be affected by the different type forms of the meningococci. We regard the protective power for laboratory animals of the antimeningococcic serum as an unsuitable index of its value in human medicine and as inferior to the agglutination titer as a standard of potency.
Publication Date: 1918-11-30 PubMed ID: 19868294PubMed Central: PMC2126311DOI: 10.1084/jem.28.6.779Google Scholar: Lookup
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- Journal Article
Summary
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The study investigated the protective ability of antimeningococcal serum against infection, but concluded that its usefulness in lab animals does not signify its effectiveness in human medicine, and this aspect of the serum is not a superior benchmark of its strength compared to the agglutination titer.
Objective of the Study
- The main objective of this study was to test the protective reaction of antimeningococcal serum against infection to determine its potency.
Methodology and Results
- The researchers conducted various experiments, the outcomes of which revealed considerable variation and apparently bore no causal connection with the quality of the tested sera.
- The quality of sera was evaluated based on factors such as the immunization period of horses from which they were derived, and their perceived efficiency in human cases of epidemic meningitis.
- The study results also showed no conformity with the agglutination titer of the tested sera and were not affected by the different type forms of meningococci.
Conclusion
- The study concluded that the protective property of the antimeningococcal serum in laboratory animals is not a suitable standard measure of its value in human medicine.
- Furthermore, researchers formed the opinion that this feature of the serum is not a better standard for measuring its potency than the agglutination titer.
Cite This Article
APA
Amoss HL, Marsh P.
(1918).
STANDARDIZATION OF ANTIMENINGOCOCCIC SERUM.
J Exp Med, 28(6), 779-790.
https://doi.org/10.1084/jem.28.6.779 Publication
Researcher Affiliations
- Laboratories of The Rockefeller Institute for Medical Research.
References
This article includes 5 references
- Flexner S. CONCERNING A SERUM-THERAPY FOR EXPERIMENTAL INFECTION WITH DIPLOCOCCUS INTRACELLULARIS.. J Exp Med 1907 Mar 14;9(2):168-85.
- Amoss HL, Wollstein M. A METHOD FOR THE RAPID PREPARATION OF ANTIMENINGITIS SERUM.. J Exp Med 1916 Mar 1;23(3):403-17.
- Flexner S, Amoss HL. CHEMICAL VERSUS SERUM TREATMENT OF EPIDEMIC MENINGITIS.. J Exp Med 1916 May 1;23(5):683-701.
- Flexner S. CONTRIBUTIONS TO THE BIOLOGY OF DIPLOCOCCUS INTRACELLULARIS.. J Exp Med 1907 Mar 14;9(2):105-41.
- Jobling JW. STANDARDIZATION OF THE ANTIMENINGITIS SERUM.. J Exp Med 1909 Jul 17;11(4):614-21.
Citations
This article has been cited 1 times.- . Références bibliographiques.. Bull World Health Organ 1963;28 Suppl(Suppl):100-14.
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