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[Standing behavior in horses after inhalation anesthesia with isoflurane (Isoflo) and postanesthetic sedation with romifidine (Sedivet) or xylazine (Rompun)].
Abstract: Isofluorane is a modern, only slightly depressive inhalation anaesthetic with excellent pharmacologic characteristics in use in equine medicine. In contrast to halothane, isofluorane is hardly broken down in the liver, but is eliminated by the lung. It low solubility in blood permits excellent control of anaesthesia. However, due to its swift elimination from the organism there is heightened risk of premature recovery from isofluorane anaesthesia. In this study the recovery phases of 96 horses were monitored for its duration and the animals' physical coordination. The horses were divided into four groups. Two groups were sedated with xylazine, one of which received postanaesthetic sedation with xylazine, the other saline solution only. The other two groups were sedated with romifidine, either with or without postanaesthetic sedation after general anaesthesia. In this study the horses of Group 4, sedated with 0.02 mg/kg BW romifidine at the moment of extubation, showed the best recovery phase. The number of attempts to arise was reduced and coordination was better. Similar results were obtained by postanaesthetic sedation with 0.2 mg/kg BW xylazine (Group 2). Premedication with 0.08 mg/kg BW romifidine without postanaesthetic sedation (Group 3) could be carried out at mean duration of anaesthesia of 85 minutes with no negative effects observed during the recovery period. Premedication with xylazine without postanaesthetic sedation (Group 1) is not to be recommended, as the number of attemps to stand up was significantly higher and coordination was either weak or significantly poorer than in the other three groups. The results of this study show that post-anaesthetic sedation of horses with an alpha 2-adrenoceptor agonist can improve the recovery phase after inhalant anaesthesia with isofluorane in regard to the number of attempts to arise and the animals' physical coordination.
Publication Date: 2003-07-18 PubMed ID: 12866257 The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- English Abstract
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article investigates recovery stages and physical coordination of horses after inhalation of isofluorane anesthesia followed by postanesthetic sedation using romifidine or xylazine. The study concluded that sedating horses with romifidine at the moment of extubation significantly improved their recovery phase.
Methodology and Groups
- The research monitored the recovery phases of 96 horses.
- The animals were split into four groups depending on the sedative used and whether they received postanesthesia sedation or not.
- Two groups were sedated with xylazine (Groups 1 and 2), one of these groups received postanesthetic sedation with xylazine (Group 2) and the other only received saline solution (Group 1).
- The remaining two groups were sedated with romifidine, with one receiving postanaesthetic sedation (Group 4) and the other one not (Group 3).
Outcomes
- Group 4, sedated with 0.02 mg/kg BW romifidine at extubation, exhibited the best recovery phase with decreased attempts to arise and improved coordination.
- Group 2, which received postanesthetic sedation with 0.2 mg/kg BW xylazine, showed results similar to Group 4.
- Group 3, premedicated with 0.08 mg/kg BW romifidine without postanesthetic sedation, showed no adverse effects after a mean duration of anesthesia of 85 minutes.
- Group 1, premedicated with xylazine without postanesthetic sedation, had a higher number of attempts to stand up and displayed weaker coordination, making it not recommended as per the study.
Conclusion
- The research shows that applying post-anesthetic sedation to horses with an alpha 2-adrenoceptor agonist can enhance the recovery phase after inhaling isofluorane anesthesia. It significantly decreases the number of attempts to arise and improves physical coordination.
Cite This Article
APA
Bienert A, Bartmann CP, von Oppen T, Poppe C, Schiemann V, Deegen E.
(2003).
[Standing behavior in horses after inhalation anesthesia with isoflurane (Isoflo) and postanesthetic sedation with romifidine (Sedivet) or xylazine (Rompun)].
Dtsch Tierarztl Wochenschr, 110(6), 244-248.
Publication
Researcher Affiliations
- Klinik für Pferde, Tierärztliche Hochschule Hannover. a.bienert@tiho-hannover.de
MeSH Terms
- Adrenergic alpha-Agonists
- Anesthetics, Inhalation
- Animals
- Horses / physiology
- Imidazoles
- Isoflurane
- Preanesthetic Medication / adverse effects
- Xylazine
Citations
This article has been cited 3 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature. Animals (Basel) 2021 Jun 14;11(6).
- Bauquier SH, Kona-Boun JJ. [Comparison of the effects of xylazine and romifidine administered perioperatively on the recovery of anesthetized horses]. Can Vet J 2011 Sep;52(9):987-93.
- Zullig KL, Murphree E, Reinscheid RK, Janik J, Callahan P. Effect of orphanin FQ/nociceptin (OFQ/N) and isoflurane on the prolactin secretory response in OFQ/N knockout mice. Peptides 2007 Aug;28(8):1611-4.
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